Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102672 - 102672
Published: Dec. 10, 2024
Language: Английский
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 2, 2024
Abstract Background Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake milk production, which can lead to higher mortality rates newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known improve resistance. However, whether supplementing LGG sensitivity sows enhance lactation performance, particularly the early survival of offspring remains unclear. Hence, we explored effects mechanisms during on sow sensitivity, survival. In total, 20 were randomly allocated an ( n = 10) control group 10). Results sows, supplementation significantly improved increased intake, production colostrum lactose levels enhanced piglet Moreover, treatment reshaped gut microbiota notably increasing diversity enriching relative abundance sensitivity-associated probiotics such as , Bifidobacterium Bacteroides . Serum metabolite amino acid profiling late-gestation also revealed decreased branched-chain kynurenine serum following supplementation. Further analyses highlighted a correlation between mitigated pregnancy by reshaping changes metabolism. Furthermore, maternal immunity piglets, reduced inflammation, facilitated establishment microbiota. Conclusions We provide first evidence that mitigates enhances modulating
Language: Английский
Citations
2
npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: Dec. 30, 2024
Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric α-linolenic acids still not fully understood. This study examined lauric-α-linolenic structural lipids (ALSL) physical mixture (PM) a similar fatty acid composition in mice obesity induced by high-fat diet (HFD). The data indicated that ALSL is more effective than PM counteracting obesity, insulin resistance, hyperlipidaemia, liver injury, systemic inflammation HFD-induced mice. These effects may be associated regulation gut microbiota. significantly upregulated abundance Dubosiella, Lactobacillus, Bifidobacterium while reducing Ileibacterium. Furthermore, therapy increased levels acetic acid, propionic total short-chain acids. Correlation analysis found positive changes these microbes correlated positively anti-inflammatory, insulin-sensitizing, anti-obesity ALSL.
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104948 - 104948
Published: Aug. 23, 2024
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116760 - 116760
Published: May 23, 2024
With the increasing prevalence of metabolic disorders, hyperglycemia has become a common risk factor that endangers people's lives and need for new drug solutions is burgeoning. Trans-2, 4-dimethoxystilbene (TDMS), synthetic stilbene, been found as novel hypoglycemic small molecule from glucose consumption test. Normal C57BL/6 J mice, mouse models type 1 diabetes mellitus diet-induced obesity subjected to TDMS gavage were with lower glycemic levels better control. significantly improved symptoms polydipsia wasting in diabetic could rise their body temperature at same time. It was promote expression key genes metabolism HepG2, do TDMS-treated liver, while it improve intestinal flora relieve dysbiosis hyperglycemic models, which turn affected its function forming gut-liver axis. We further fished PPARγ by virtual screening be promoted both in-vitro in-vivo, regulated upstream signaling AMPKα phosphorylation. As molecule, proven promising improvements amelioration symptoms. absorption utilization liver mice. Therefore, expected acts through axis via AMPKα-PPARγ pathway improving metabolism, bringing hope patients disorders.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: unknown
Published: June 1, 2024
The prevalence of high blood pressure is on the rise among younger individuals, and recent findings have linked exercise to changes in diversity configuration gut microbiota. However, specific modifications one's diet, such as incorporating blueberries while engaging physical activity, can also influence this association. To explore effects blueberry consumption bacteria, we conducted an eight-week study involving healthy hypertensive college students. Our microbiome analysis revealed slight shifts bacteria composition response increased with significant g_[Eubacterium]_eligens_group observed students who regularly consumed blueberries. Although supplementation had a negligible impact microbiota students, it significantly boosted production butyric acid young adults. These results suggest that variety abundance brought about by may be tied alterations body patients hypertension. This aims reveal from unique perspective, suggesting taking exercises.
Language: Английский
Citations
0
Journal of Complementary and Integrative Medicine, Journal Year: 2024, Volume and Issue: 21(3), P. 349 - 359
Published: July 2, 2024
Abstract Objectives This study investigated the antidiabetic effects of methanolic extract E. africanum (MEEA) stem bark on streptozotocin (STZ)-induced diabetic nephropathy (DN) in Wistar rats. Methods The vitro enzyme (α-amylase) inhibitory activity MEEA was measured using a standard procedure. Diabetic rats with fasting blood glucose above 250 mg/dL were considered and divided into following groups: control (distilled water-treated), diabetic-control, metformin (100 mg/kg), diabetes + (150 (300 mg/kg) via oral gavage once daily for 14 days. At end experimental period, kidney tissues collected biochemical histological analyses. Kidney apoptosis marker gene expression by real-time quantitative PCR. Results exhibited α-amylase effects. significantly (p<0.05) reduced STZ-induced increases glucose, serum urea, creatinine, uric acid, alanine aminotransferase, alkaline phosphatase, malondialdehyde increased decreases superoxide dismutase, catalase, glutathione. In addition, protects against DN downregulating mRNA cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), cAMP-response binding (CREB), cFOS upregulating B-cell lymphoma 2 (Bcl-2), suggesting that nephroprotective ability is due to modulation cAMP/PKA/CREB/cFOS signaling pathway. Furthermore, treatment protected histopathological alterations observed Conclusions data from this suggest modulates homeostasis inhibits redox imbalance
Language: Английский
Citations
0
Pancreatology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
0
Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3163 - 3163
Published: Oct. 4, 2024
Momordica charantia L. saponins (MCS) may promote wound-healing properties but the underlying mechanisms are unclear. This study aimed to examine effects and of MCS on diabetic wounds. The results have shown that higher intake lowered fasting blood glucose levels, serum lipids, lipopolysaccharides in mice. MCS-treated mice exhibited faster wound healing than control groups. After three days, groups a area reduction only 19.3%, while 39.75% was observed following high-dose treatment. Five potential biomarkers were screened metabolomics study. revealed mainly regulated glycerophospholipid metabolism, fructose mannose steroid hormone biosynthesis, pyrimidine Krebs cycle, thus affecting healing. Overall, could not exert hypoglycemic effect also healing, making it treatment option for diabetes-related
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0313395 - e0313395
Published: Nov. 21, 2024
Lacticaseibacillus rhamnosus SD11 (SD11) has several health benefits for the host, including antidiabetic, anti-inflammatory, and antimicrobial effects. However, antidiabetic mechanism of not been clearly elucidated. The current study assessed effects associated underlying mechanisms on streptozotocin (STZ)-induced diabetic mice. Compared with normal control, supplementation 4 weeks significantly improved metabolic profiles, body weight (BW), fasting blood glucose (FBG), insulin level (FIN), liver index (LI), in conjunction a lower NAS score. A notable reduction function parameters aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP) total cholesterol (TC), together histopathology studies, supported recovery by SD11. closer examination two major markers pathway, receptor (INSR) substrate (IRS)-1, revealed that could exert its control through upregulation these molecules, which were almost demolished nontreated livers. Additionally, SD11-treated mice exhibited alleviation oxidative stress enzymes; downregulation proinflammatory cytokines, interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ; decreased infiltration macrophages into tissue. These findings concomitant preservation tight junction proteins occludin zona (ZO)-1, turn lowered levels inflammatory cytokines IL-1β TNF-α prevented colon tissue injury to some extent. Notably, results identical those Overall, our delays deterioration reduces lesions provide evidence use as an effective strategy improve diabetes-related symptoms.
Language: Английский
Citations
0
Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102672 - 102672
Published: Dec. 10, 2024
Language: Английский
Citations
0