Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105299 - 105299
Published: Oct. 1, 2024
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 176 - 176
Published: Jan. 13, 2024
Antibiotics comprise one of the most successful groups pharmaceutical products. Still, they have been associated with developing bacterial resistance, which has become severe problems threatening human health today. This context prompted development new antibiotics or co-treatments using innovative tools to reverse resistance context, combat infections, and offer promising antibacterial therapy. For alternatives, strategies, and/or for controlling growth, it is necessary know target bacteria, their classification, morphological characteristics, currently used therapies, respective mechanisms action. In this regard, genomics, through sequencing genomes, generated information on diverse genetic resources, aiding in discovery molecules antibiotic compounds. Nanotechnology applied propose antimicrobials, revitalize existing drug options, use strategic encapsulating agents biochemical making them more effective against various bacteria. Advanced knowledge contributes construction databases, resulting advances bioinformatics antimicrobials. Moreover, enables silico antimicrobial susceptibility testing without need cultivate pathogen, reducing costs time. review presents biomedical technological innovations studied recent years develop improve natural synthetic reduce promote well-being, benefit users.
Language: Английский
Citations
5
World Journal of Gastrointestinal Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 3, 2025
In recent years, nosocomial infections caused by Clostridium difficile (C. ) have risen, becoming a leading cause of hospital-acquired diarrhea. The global prevalence C. infection (CDI) varies across regions and populations. diagnosis relies primarily on laboratory testing, including toxin, glutamate dehydrogenase, nucleic acid amplification tests. Treatment strategies for CDI include antimicrobial therapy (e.g., metronidazole, vancomycin, fidamycin), fecal transplantation, immunotherapy belotozumab), depending the patient’s specificity severity. This paper reviews research CDI’s epidemiological characteristics, risk factors, diagnosis, treatment, prevention, aiming to support hospitals public health initiatives in implementing effective detection, treatment strategies.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 14, 2024
Introduction In an era increasingly defined by the challenge of antibiotic resistance, this study offers groundbreaking insights into antibacterial properties two distinct Lactiplantibacillus plantarum strains, TE0907 and TE1809, hailing from unique ecosystem Bufo gargarizans . It uniquely focuses on elucidating intricate components mechanisms that empower these strains with their notable capabilities. Methods The research employs a multi-omics approach, including agar diffusion tests to assess efficacy adhesion assays HT-29 cells understand preliminary mechanisms. Additionally, gas chromatography-mass spectrometry (GC-MS) is employed analyze production organic acids, notably acetic acid, whole-genome sequencing utilized identify genes linked biosynthesis antibiotics bacteriocin-coding domains. Results comparative analysis highlighted exceptional mean inhibitory zones measured at 14.97 15.98 mm, respectively. A pivotal discovery was significant synthesis acid in both demonstrated robust correlation coefficient (cor ≥ 0.943), linking its abundance antimicrobial efficiency. Genomic exploration uncovered diverse range elements involved similar tetracycline vancomycin potential regions encoding bacteriocins, Enterolysin Plantaricin. Conclusion This illuminates remarkable intrinsic L. sourced B. findings underscore strains' extensive biochemical enzymatic armamentarium, offering valuable role antagonizing enteric pathogens. These results lay down comprehensive analytical foundation for clinical deployment safeguarding animal gut health, thereby enriching our understanding probiotic bacteria realm interventions.
Language: Английский
Citations
3
Microbiological Research, Journal Year: 2024, Volume and Issue: 292, P. 127995 - 127995
Published: Dec. 7, 2024
Language: Английский
Citations
2
Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4026 - 4026
Published: Dec. 12, 2024
Spore-forming bacterial species pose a serious threat to food plants and healthcare facilities that use high-temperature processing sterilizing techniques sanitize medical equipment items. These severe conditions trigger sporulation, which is the process by spore-forming bacteria, such as those of Bacillus Clostridium species, begin produce spores, are extremely resilient entities capable withstanding adverse environmental circumstances. Additionally, these spores resistant wide range disinfectants antibacterial therapies, hydrolytic enzymes, radiation, chemicals, antibiotics. Because their ability combat bacteria through several biological pathways, selenium nanoparticles (SeNPs) have emerged an effective method for either eliminating or preventing formation bacteria. This review aims investigate every potential pathway entry mechanism SeNPs impact spores. SeNPs' efficacy against infections reviewed. To precisely explain various factors can affect effectiveness, more research necessary.
Language: Английский
Citations
2
Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105299 - 105299
Published: Oct. 1, 2024
Language: Английский
Citations
0