Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 23, 2025

Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic environmental factors with immune system gut microbiome, leading to disruption intestinal barrier. Normally, epithelium, interact maintain homeostasis. However, when this equilibrium is disturbed, harmful cycle dysbiosis, dysregulation, inflammation emerges, resulting barrier dysfunction progression. Among various risk factors, diet significantly influences epithelial integrity architectural stability through both direct indirect mechanisms, shaping entire continuum from pre-clinical prevention active phase treatment remission maintenance. This review provides insights impact dietary content eating behaviors UC, focusing specific food, food groups, nutrients, intermittent fasting, while providing detailed explanation why microbiota may mediate sustained effects across all stages UC. Additionally, it addresses limitations current studies, explores underexamined areas proposes potential directions for future expansion. Not applicable.

Language: Английский

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Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 112024 - 112024

Published: April 11, 2024

Language: Английский

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Sea Cucumber Peptides Ameliorate DSS-Induced Ulcerative Colitis: The Role of the Gut Microbiota, the Intestinal Barrier, and Macrophage Polarization

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4813 - 4813

Published: Nov. 17, 2023

The incidence of ulcerative colitis (UC) is increasing annually. There are few treatments for UC patients, and some drugs have serious side effects. Sea cucumber peptide (SCP) has anti-inflammatory, antioxidant other biological activities, various sea species in pharmaceutical development. However, relevant studies on the effects SCP progression still lacking. In this study, a mouse model acute was induced by 3% dextran sulfate (DSS), effect 500 mg/kg investigated. results showed that can alleviate DSS-induced colon damage intestinal barrier damage. significantly inhibited expression inflammatory factors oxidative stress mice. reversed microbiota dysregulation DSS, growth Sutterella, Prevotella_9 Escherichia-Shigella harmful bacteria, increased abundance Lachnospiraceae_NK4A136_group. At same time, treatment LPS-induced polarization M1 macrophages, which may be mediated two monopeptides, IPGAPGVP TGPIGPPGSP, via FPR2. conclusion, protect against modulating composition inhibiting macrophages.

Language: Английский

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Walnut peptide ameliorates DSS-induced colitis in mice by inhibiting inflammation and modulating gut microbiota

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106344 - 106344

Published: July 6, 2024

Language: Английский

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Antarctic krill oil phosphatidylcholine alleviates visceral hypersensitivity in irritable bowel syndrome: A lipidomics perspective

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106478 - 106478

Published: March 1, 2025

Language: Английский

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Lactobacillus plantarum 17-1 Ameliorates DSS-Induced Colitis by Modulating the Colonic Microbiota Composition and Metabolome in Mice

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1348 - 1348

Published: April 15, 2025

Background/Objectives: Lactobacillus strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, strain specificity limited stress resistance of restricts its therapeutic effectiveness. The aim this study was to investigate effects dietary supplementation with microencapsulated plantarum 17-1 on intestinal immune responses, gut microbiota composition, metabolic characteristics colitis mice. Methods: Mice were pre-fed a diet containing 3 weeks then treated 2.5% dextran sulfate sodium (DSS) drinking water 8 days induce colitis. Results: results showed that effectively alleviated clinical symptoms histopathological features mice suppressed up-regulation pro-inflammatory cytokines IL-6 IL-17 colon Additionally, significantly increased relative abundance several beneficial bacterial taxa, including Ruminococcaceae_UCG_014, Bacteroides, Prevotellaceae_UCG_001, Lactococcus, Weissella, Pediococcus, so on. Moreover, it regulated levels multiple inflammation-related metabolites involved linolenic acid metabolism, arachidonic primary bile biosynthesis, tyrosine metabolism. Conclusions: These suggest reduced inflammation by modulating composition characteristics, which may serve strategy IBD.

Language: Английский

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Vitamin K2 alleviates dextran sulfate sodium-induced colitis via inflammatory responses, gut barrier integrity, and the gut microbiota in mice

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 136091 - 136091

Published: Sept. 30, 2024

Language: Английский

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Analysis of bioactive compounds of hen egg components at the first half of incubation

Journal of Food Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract A comparative analysis of mass–volume characteristics structural and morphological components hen eggs before incubation on the fifth (HH25–HH27) 10th (HH36) days was carried out. During incubation, egg weight decreased by 9.25% (10 days), mainly due to a decrease in albumen (35.8%). The ratio lipid‐soluble fraction (LSF) water‐soluble (WSF) mixed yolk did not change significantly. total amount solids substances practically does during incubation. Antiradical activity increased significantly more than three times day additionally 38.6% at relation day. Total antioxidant 18.9% 24.3% day, compared Transformation main WSF LSF albumin, yolk, chicken embryo (CE) studied using high‐performance liquid chromatography gas with mass spectrometry. On an increase number high‐molecular proteins is recorded, which indicates activation enzymatic processes transformation into organs tissues CE. This may cause biological substances. It found that conditions vitro digestion, antiradical increases two times, anti‐inflammatory 2.4 angiotensin‐converting enzyme inhibitory effect occurs 10‐day egg.

Language: Английский

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UPLC-MS based lipidomics analysis on optimization of soybean phosphatidylethanolamine extraction

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101578 - 101578

Published: June 18, 2024

Soybean-derived phosphatidylethanolamine (PE) is a valuable phospholipid component yet its high-purity form costly and molecular structure poorly understood. The present study combined solvent extraction cryopurification to purify PE. optimal conditions were as follows: material-liquid ratio 1:15 (g/mL), ethanol base concentration 100:4 (Vanhydrous /V25% ammonia), temperature 40 °C, time 60 min, twice. were: 1:60, 100:6 ethanol/V25% freezing − 20 h. UPLC-QTOF-MS/MS analysis revealed composition of raw material, crude product, purified product. results showed that the purity PE in products was 76.74%, yield 72.43% under conditions. 181 molecules quantified. successfully explored preparation method It provides basis for subsequent exploration biofunction potential applications.

Language: Английский

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Uplc-Ms Based Lipidomic on Optimization of Soybean Phosphatidylethanolamine Extraction

Published: Jan. 1, 2024

Phosphatidylethanolamine (PE) is a valuable phospholipid component derived from soybeans. However, high-purity PE expensive and its molecular composition has been little studied. To investigate the optimal extraction method of soybean to reveal composition, present study combined solvent cryopurification purify PE. Ultra-performance liquid chromatography-tandem time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) was used analyze raw material, crude product, purified product for their composition. The results showed that purity in products as high 76.74%, yield 72.43% under conditions. 181 molecules were identified quantified. rich polyunsaturated fatty acids (PUFA) with content 90.48%. Therefore, successfully explored preparation. It provides basis subsequent exploration biofunction potential applications.

Language: Английский

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