Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101724 - 101724
Published: Aug. 10, 2024
Evaluation for biological impact of food emulsions is fundamental their application. In present study, we utilized a NaCas-DGMO (sodium caseinate-decylglycerol monooleate) stabilized emulsion to improve resveratrol's (Res) stability, and bioavailability. The
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116207 - 116207
Published: Jan. 31, 2024
Lung cancer ranks among the most prevalent forms of and remains a significant factor in cancer-related mortality across world. It poses challenges to healthcare systems society as whole due its high incidence, rates, late-stage diagnosis. Resveratrol (RV), natural compound found various plants, has shown potential nanomedicine for lung treatment. RV varied effects on cells, including promoting apoptosis by increasing pro-apoptotic proteins (Bax Bak) decreasing anti-apoptotic (Bcl-2). also hinders cell proliferation influencing important signaling pathways (MAPK, mTOR, PI3K/Akt, Wnt/β-catenin) that govern progression. In addition, acts potent antioxidant, diminishing oxidative stress safeguarding cells against DNA damage. However, using alone treatment drawbacks, such low bioavailability, lack targeting ability, susceptibility degradation. contrast, nanoparticle-based delivery address these limitations hold promise improving outcomes cancer; nanoparticle formulations offer advantages improved drug delivery, increased stability, controlled release, targeted cells. This article will provide an overview cancer, explore therapeutic agent, discuss benefits highlight nanoparticles treatment, cancer. By optimizing clinical application, future studies aim enhance overall improve prognosis patients.
Language: Английский
Citations
24
Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101540 - 101540
Published: June 10, 2024
Plant proteins can meet consumers' demand for healthy and sustainable alternatives to animal proteins. It has been reported possess numerous health benefits is widely used in the food industry. However, conventional extraction methods are time-consuming, energy-intensive, as well environmentally unfriendly. also limited application due off-flavors, allergies, anti-nutritional factors. Therefore, this paper discusses challenges limitations of processes. The current advances green technologies summarized. In addition, improve nutritional value, bioactivity, functional organoleptic properties plant proteins, strategies reduce their allergenicity mentioned. Finally, examples applications industry presented. This review aims stimulate thinking generate new ideas future research. will provide broad perspectives
Language: Английский
Citations
18
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1270 - 1270
Published: Oct. 18, 2024
Periodontitis affects up to 40% of adults over 60 years old and is a consequence gingivitis. characterized by chronic inflammation, periodontal damage, alveolar bone resorption. The nuclear factor erythroid 2-related 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays key role in periodontitis modulating redox balance inflammation the periodontium. However, NRF2 expression decreased gingival tissues patients with while oxidative stress significantly increased this pathology. Oxidative lipopolysaccharide (LPS) produced gram-negative bacteria favor production inflammatory causing favoring bone. In review, we analyzed current literature regarding natural synthetic compounds NRF2/KEAP1 vitro vivo models order evaluate new potential treatments that can improve outcome disease.
Language: Английский
Citations
17
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129288 - 129288
Published: Jan. 10, 2024
Hydroxypropyl methylcellulose (HPMC)-based microparticles and modified starch emulsions (OSA-MS) were loaded with resveratrol characterized regarding their physicochemical thermal properties. Both delivery systems subject to an in vitro gastrointestinal digestion assess the bioaccessibility of resveratrol. In addition, cell-based studies conducted after cytotoxicity oxidative stress assessed. HPMC-based displayed higher average sizes (d) lower polydispersity index (PDI) (d = 948 nm, PDI < 0.2) when compared OSA-MS-based 217 0.3). proved protect under digestive conditions, leading increase bioaccessibility. Resveratrol-loaded HPMC-microparticles showed a (56.7 %) than resveratrol-loaded (19.7 %). Digested samples tested differentiated co-cultures Caco-2 HT29-MTX, aiming at assessing stress, lack was observed for all samples. Results increasing antioxidant activity, 1.6-fold 1.4-fold increases over activity free resveratrol, OSA-MS nanoemulsions, respectively. Our results offer insight into physiological relevancy due assessment post-digestion highlight protection that use micro-nano can confer potential be used as functional food ingredients capable providing benefits upon consumption.
Language: Английский
Citations
8
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 24, 2024
Abstract Reliable in-vitro digestion models that are able to successfully replicate the conditions found in human gastrointestinal tract key assess fate and efficiency of new formulations aimed for oral consumption. However, current either lack capability crucial dynamics or require large volumes sample/reagents, which can be scarce when working with nanomaterials under development. Here, we propose a miniaturised system, digestion-chip, based on incubation chambers integrated polymethylmethacrylate device. The digestion-chip incorporates dynamic features digestion, such as gradual acidification addition enzymes simulated fluids gastric phase, controlled emptying, while maintaining low complexity using small sample reagents. In addition, approach integrates real-time automated closed-loop control two parameters, pH temperature, during main phases (gastric intestinal) an accuracy down ± 0.1 °C 0.2 points. experimental results demonstrate replicates gold standard static INFOGEST protocol semi-dynamic kinetics reliably fitted first kinetic order model. These devices easily adapted automated, sensorised, inexpensive platform will enable reliable, low-cost efficient assessment bioaccessibility expensive drugs, bioactive ingredients nanoengineered materials consumption, thereby avoiding unnecessary animal testing.
Language: Английский
Citations
4
Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 782 - 782
Published: June 27, 2024
Cadmium (Cd) toxicity poses a significant threat to human health and the environment due its widespread occurrence persistence. In recent years, considerable attention has been directed towards exploring natural compounds with potential protective effects against Cd-induced toxicity. Among these compounds, resveratrol (RV) emerged as promising candidate, demonstrating range of beneficial attributed antioxidant anti-inflammatory properties. This literature review systematically evaluates role RV Cd toxicity, considering various mechanisms action involved. A comprehensive analysis both in vitro vivo studies is conducted provide understanding efficacy mitigating damage. Additionally, this highlights importance phytoremediation strategies addressing contamination, emphasizing enhancing efficiency such remediation techniques. Through integration diverse research findings, underscores therapeutic combating need for further investigation elucidate precise optimize application environmental clinical settings.
Language: Английский
Citations
4
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 504 - 504
Published: Jan. 30, 2025
Objectives: Resveratrol (RES) is well documented for its multiple health benefits, with a notable impact on cancer prevention and therapy. This study aimed to evaluate the effect of RES supplementation oxidative stress in patients head neck (HNC) receiving home enteral nutrition (HEN). Methods: randomized, single-center, open-label involved 72 adult patients, 40 completing intervention. Participants intervention group received 400 mg liposomal daily 12 weeks alongside HEN, while control HEN only. Body composition markers—including total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced (GSH)—were measured at baseline after weeks. Results: Significant increases TAC SOD activity were observed both groups. GPx increased significantly only group. MDA levels rose groups but more pronounced GSH showed no significant changes. Phase angle (PhA) group, change was Conclusions: may enhance defenses, as evidenced by improvements levels, supporting balance HNC HEN. The higher reflect RES’s dual pro-oxidant activities. Additionally, increase PhA suggests potential cellular benefits. These findings highlight complementary clinical oncology, warranting further investigation clarify therapeutic effects care.
Language: Английский
Citations
0
Materials, Journal Year: 2025, Volume and Issue: 18(2), P. 457 - 457
Published: Jan. 20, 2025
Biopolymers represent a significant class of materials with potential applications in skin care due to their beneficial properties. Resveratrol is natural substance that exhibits range biological activities, including the scavenging free radicals and anti-inflammatory anti-aging effects. In this study, chitosan/konjac glucomannan resveratrol-enriched thin films were prepared. The enrichment biomaterials active ingredients common practice, as it allows desired properties be obtained final product. To characterize films, several analyses performed, infrared spectroscopy, imaging samples by SEM AFM techniques, swelling analysis pH 5.5 7.4, mechanical antioxidant assays, contact angle measurements, determination resveratrol release profile under mimicking conditions. incorporation into matrices resulted modifications chemical structure film morphology. characteristics additives found undergo deterioration. sample containing 10% exhibited higher degree than other films. resveratrol-modified demonstrated notable capacity, reduced angle, enhanced wettability. occurred rapidly initially, maximum 84% 56% released depending on type. Thus, proposed formulations have promising properties, particular good high potential, improved wettability, may serve dressings after further investigation.
Language: Английский
Citations
0
European Journal of Lipid Science and Technology, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
ABSTRACT The aim of this study was to produce and characterize micro‐ nanoparticulate lipid carriers for pomegranate seed oil (PSO) preserve its functional properties. results the dynamic light scattering (DLS) technique revealed that formulation proportions minimally affected particle size, with nanoparticles (LNs) ranging from 308 325 nm, LN4:1 being most monodisperse formulation. Lipid microparticles (LMs) ranged 1251 4364 demonstrating efficiency hot homogenization rotor–stator micrometer‐sized particles. SEM analysis further confirmed morphology, showing well‐defined spherical shapes presence clusters, likely due lyophilization process nature carriers. All formulations exhibited stable dispersion (high negative zeta potential). Formulations greater color difference (Δ E *) a lower polydispersity index (PDI), such as LN4:1, indicate more effective enhanced protection bioactive components. Compatibility preservation PSO characteristics were by XRD FTIR. Encapsulation values 40.0% 66.1%, indicating satisfactory encapsulation. Furthermore, encapsulation effectively protected antioxidant activity PSO, decrease in DPPH scavenging percentage 55.4% (free PSO) 41.4% 51.3% (lipid carriers). Overall, demonstrates feasibility producing methods employed, suggesting applications sustainable packaging. Practical Applications : development micro offers significant potential food industry, particularly creating biodegradable active enhances stability compounds, including punicic acid, tocopherols, polyphenols, protecting them oxidative degradation. This improves shelf life properties products. Additionally, controlled release mechanism these can enhance bioavailability PSO's antioxidants, contributing improved nutritional value health benefits. These findings suggest foods, nutraceuticals, packaging solutions maintain quality safety products over time.
Language: Английский
Citations
0
Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104761 - 104761
Published: Oct. 1, 2024
Language: Английский
Citations
3