Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 104 - 104

Published: Jan. 17, 2025

Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized role oxidative stress in initiation and progression breast cancer. This article reviews how imbalance influences occurrence advancement cancer, elucidating intricate mechanisms through which reactive oxygen species (ROS) operate this context their potential therapeutic applications. By highlighting these critical insights, review aims to enhance our understanding as a target for innovative strategies management

Language: Английский

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Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 149 - 149

Published: Jan. 19, 2025

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder marked by the progressive degeneration of midbrain dopaminergic neurons and resultant locomotor dysfunction. Despite over two centuries recognition as chronic disease, exact pathogenesis PD remains elusive. The onset progression involve multiple complex pathological processes, with dysfunctional autophagy elevated oxidative stress serving critical contributors. Notably, emerging research has underscored interplay between in pathogenesis. Given limited efficacy therapies targeting either dysfunction or stress, it crucial to elucidate intricate mechanisms governing their develop more effective therapeutics. This review overviews role nuclear factor erythroid 2-related 2 (Nrf2), pivotal transcriptional regulator orchestrating cellular defense against these processes. By elucidating key processes PD, this will deepen our comprehensive understanding multifaceted underlying may uncover potential strategies for its prevention treatment.

Language: Английский

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Ligustrazine hydrochloride Prevents Ferroptosis by Activating the NRF2 Signaling Pathway in a High-Altitude Cerebral Edema Rat Model

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1110 - 1110

Published: Jan. 27, 2025

High-altitude cerebral edema (HACE) is a disorder caused by low pressure and hypoxia at high altitudes. Nevertheless, as of now, there still scarcity safe effective prevention treatment methods. The active component Ligusticum Chuanxiong, namely Ligustrazine hydrochloride (LH), has shown potential in the HACE due to its anti-inflammatory, antioxidant, neuroprotective effects nervous system disorders. Consequently, protective effect LH on mechanism need be further explored. Prior modeling, 90 male Sprague-Dawley rats were pretreated with different doses drugs, including (100 mg/kg 50 mg/kg), dexamethasone (4 ML385 (30 mg/kg). Subsequently, placed low-pressure anoxic chamber simulating plateau environment establish rat model. mechanisms elucidated through determination brain water content, HE staining, ELISA, immunofluorescence, molecular docking, dynamics simulation, western blot, other techniques. results showed, first all, that pretreatment can effectively reduce content; down-regulate expression AQP4, HIF-1α, VEGF proteins; alleviate damage tissue nerve cells. Secondly, compared group, significantly MDA levels increase GSH SOD levels. Additionally, decreased inflammatory factors IL-1β, IL-6, TNF-α; reduced total iron content tissue; increased ferroptosis-related proteins such SLC7A11, GPX4, FTH1; alleviated ferroptosis occurrence. Molecular docking simulations show strong binding affinity for NRF2 signaling. Western blot analysis confirmed promotes translocation from cytoplasm nucleus activates signaling pathway exert an antioxidant effect. inhibitor reverse anti-oxidative stress tissue. In summary, may have activating pathway, inhibiting ferroptosis, resisting oxidative stress.

Language: Английский

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Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 81 - 81

Published: Jan. 12, 2025

This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for antimicrobial, anti-inflammatory, antioxidant properties. Recent research emphasizes positive role in osteogenesis, primarily through modulation osteoclast osteoblast activity via molecular pathways. Key mechanisms include reducing inflammatory cytokines, protecting against oxidative stress, upregulating growth factor essential formation. While such as Caffeic Acid Phenethyl Ester, Apigenin, Quercetin, Ferulic have been well-documented, emerging evidence points to significant roles less-studied like Pinocembrin, Kaempferol, p-Coumaric acid, Galangin. synthesizes current literature, focusing which these influence osteogenesis. Firstly, it techniques characterizing presented propolis, chemogeographic variations composition, both crude extracts isolated tissue, offering comprehensive analysis recent findings across different experimental models. Further, discusses In summary, modulate signaling pathways, including nuclear kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial factor, reactive oxygen species. These pathways receptor activator kappa-β/receptor kappa-β ligand/osteoprotegerin system, fostering cell differentiation. regulation mitigates excessive formation, stimulates activity, ultimately contributes restoration homeostasis maintaining balanced remodeling process.

Language: Английский

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Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 902 - 902

Published: Jan. 22, 2025

Aging and pregnancy are often considered opposites in a woman’s biological timeline. is defined by gradual decline the functional capabilities of an organism over its lifetime, while characterized presence transient placenta, which fosters cellular fitness necessary to support fetal growth. However, context preeclampsia, aging share common hallmarks, including clinical complications, altered phenotypes, heightened oxidative stress. Furthermore, women with pregnancies complicated preeclampsia tend experience age-related disorders earlier than those healthy pregnancies. Klotho, gene discovered fortuitously 1997 researchers studying mechanisms, primarily expressed kidneys but also lesser extent several other tissues, placenta. The Klotho protein membrane-bound that, upon cleavage ADAM10/17, released into circulation as soluble (sKlotho) where it plays role modulating This review focuses on involvement sKlotho development disorders, well expression recently Mytho gene, has been associated skeletal muscle atrophy.

Language: Английский

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Role of Natural Compounds as Anti-Cancer Agents

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 25(5), P. 293 - 294

Published: Jan. 28, 2025

Language: Английский

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Phytochemical Composition and Skin-Friendly Activities of the Ethyl Acetate Fraction in Ophioglossum vulgatum Linn., an In Vitro Study

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 345 - 345

Published: Feb. 27, 2025

Background: Ophioglossum vulgatum Linn. is a medical herb widely distributed in Southwest China. It has been used for the treatment of various diseases, including wounds or dermatitis, since ancient times, but little known about its pharmacological and pharmaceutical chemistry. Methods: The ethyl acetate fraction O. (OpvE) was prepared with reflex extraction fractional method. Its components were detected identified UPLC-Q/TOF-MS system SCIEX OS database. related biological activities underlying mechanisms predicted by computational analysis. HaCaT cells treated gradient concentrations OpvE, CCK-8 assay performed to determine cell viability. OpvE-pretreated exposed H2O2 LPS antioxidative anti-inflammatory assessment. DPPH, GSH, SOD, MDA kits evaluate oxidative stress. A serially diluted microbiota disc diffusion anti-Staphylococcus aureus activities. transcription genes semi-quantitatively studied reversed real-time PCR. Protein levels determined western blotting. Results: extract ratio OpvE 2.00 ± 0.12% (g/g). total 21 ingredients identified. analysis found that PI3K/Akt signaling pathway might be crucial target OpvE. (7.5~125 μg/mL) stimulated proliferation migration stimulating over-expressed collagen type I alpha 1 Chain (COL1A1) fibronectin (FN1) upregulating PI3K/AKT/GSK3-β pathway. In test, 250 μg/mL scavenged obvious 97.28% DPPH-released free radicals. Pretreatment inhibited H2O2-induced stress protected against LPS-induced inflammatory injury respectively regulating Nrf2/HO-1/COX2 TLR4/MYD88 pathways. also showed anti-S. properties MIC 1.2 mg/mL, this concentration, produced an 8.3 0.16 mm inhibition zone on bacterial plate. Conclusions: This work highlighted phytochemical character some bioactivities, as well underline mechanism, which would support further studies application

Language: Английский

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A Sweet Almond Globulin Multifunctional Peptide: Identification, In Silico Screening, Restraint Mechanisms to Keap1 and ACE, and Antihypertensive and Ferrous Transport Efficiency

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 907 - 907

Published: March 5, 2025

Background: Sweet almond expeller is an abundant protein resource, but there are few studies on multifunctional peptides. The purpose of this study to improve its application in food and medical industries. Methods: This investigated the identification, screening, action mechanisms antihypertensive peptides with antioxidant ferrous binding activities derived from sweet globulin hydrolysates using intergrade vitro silico methods animal model. Results: Eight novel oligopeptides were identified subfraction D; them, Pro-Met-Tyr-Gly-Gly-Gly-Met-Val (PMYGGGMV) exhibited ACE inhibitory activity (IC50: 121.16 μmol/L), ability (11.01 mg/g), quenching capacities hydroxyl (93.06%) ABTS radicals (83.67%). phenolic hydroxyl, amino, carboxyl groups PMYGGGMV linked Lys511, Tyr520, Tyr523 ACE's substrate center through four short hydrogen bonds. can inhibit Kelch-like ECH-Associated Protein 1 (Keap1)-nuclear factor erythroid 2-related 2 (Nrf2) interaction by seven residues Keap1 (including a key residue, Arg415). PMYGGMY stable during gastrointestinal digestion. Ferrous chelation did not alter effects PMYGGMY, it reduced radical scavenging (p < 0.05). Additionally, blood pressure spontaneous hypertension rates improved iron absorption across Caco-2 cells Conclusions: has potential prevent oxidative stress, hypertension, deficiency.

Language: Английский

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Role of the sulfur-containing amino acid-ROS axis in cancer chemotherapeutic drug resistance

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: unknown, P. 101238 - 101238

Published: March 1, 2025

Language: Английский

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Mitigating Effect of Taurine Combined with Corona Dormancy on Oxidative Stress in Trachinotus ovatus Under Low-Temperature Stress

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2927 - 2927

Published: March 24, 2025

The purpose of the present work was to establish transportation conditions for keeping Trachinotus ovatus alive by means corona-induced dormancy in combination with taurine. It also investigated synergistic regulatory effects on oxidative stress mitigation and immune function during low-temperature clarified underlying mechanism. pretreatment induced pulsed direct current could reduce accumulation reactive oxygen species fish under hypothermal water-restricted significantly enhance environmental adaptability ovatus. survival period rate were increased when combined taurine at a concentration 70 mg/L, activities enzymes related significantly, including catalase, superoxide dismutase (SOD), glutathione S-transferase, so on. mechanism involved upregulation mRNA expression Nrf2/Keap1 pathway components. Furthermore, supplementation found bolster Histological examinations revealed that exerted protective ultrastructural integrity liver gills, which susceptible stress-induced damage transportation. Altogether, concerted action corona mitigated responses tissue injuries live transportation, thereby providing mechanistic basis enhancement techniques.

Language: Английский

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