The Potential Mechanism of Soy Isoflavones in Treating Osteoporosis: Focusing on Bone Metabolism and Oxidative Stress

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Osteoporosis is divided into primary and secondary types. Primary osteoporosis may result from estrogen deficiency in postmenopausal women, imbalanced bone remodeling the elderly, or adolescent-type development. Secondary can be caused by factors like long-term glucocorticoid treatment, chronic kidney disease (CKD), deprivation, oxidative stress, diabetes, obesity. This review focuses on therapeutic potential of soy isoflavones for osteoporosis. At cellular level, isoflavones, as natural plant extracts phytoestrogens, are crucial osteoblastogenesis differentiation, osteoclastogenesis, osteoclast mineralization, marrow mesenchymal stromal cell differentiation. They also maintain calcium homeostasis regulating extracellular vitamin D levels. In terms mitigate it endoplasmic reticulum mitochondria, thus senescence, autophagy, processes. Moreover, relieve symptoms related to CKD inhibit secretion, which directly indirectly benefits treatment Overall, have treat enhancing health, metabolism, alleviating stress. Future research should explore phytoestrogens treating exploration focus clarifying safety, identifying side effects, determining optimal dosage regimen, developing strategies any adverse reactions. addition, further large-scale, multicenter human clinical trials necessary accurately evaluate actual effect

Language: Английский

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Antioxidant effects of Paeoniflorin and relevant molecular mechanisms as related to a variety of diseases: A review

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116772 - 116772

Published: May 28, 2024

Paeoniflorin (PF), which is the main component of Paeonia lactiflora Pall extract, one traditional Chinese medicines. The pharmacological effects associated with PF include antioxidant, immunomodulatory, anti-inflammatory, anticancer, antidepressant-like and neuroprotective effects. Our previous studies had revealed that protected melanocytes inhibited photodamage through suppression oxidative stress (OS). As OS plays a vital role in progression variety diseases, capacity for to suppress may exert important upon them. However, no review exists on these antioxidant as related various diseases. Therefore, this we summarized involved examining molecular mechanisms PF. Through its inhibit OS, has been shown beneficial several systems including nervous, cardiac/vascular, digestive, respiratory well specific diseases such diabetes, autoimmune, pregnancy related, ocular, kidney, dermatology, along distal flap necrosis, postoperative adhesions, hearing loss. Such findings provide new insights directions future research directed at development natural treatment clinical

Language: Английский

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Characteristics of the gut microbiota and serum metabolites in postmenopausal women with reduced bone mineral density

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: June 7, 2024

Introduction Emerging evidence suggests that the gut microbiota is closely associated with bone homeostasis. However, little known about relationships among mineral density (BMD) index, turnover markers, and its metabolites in postmenopausal women. Methods In this study, to understand signatures serum metabolite changes women reduced BMD, individuals normal or BMD were recruited divided into OS groups. Feces samples collected for 16S rRNA gene sequencing, liquid chromatography coupled mass spectrometry (LC-MS)-based metabolomics integrated analysis. Results The results demonstrated bacterial richness diversity greater group than group. Additionally, distinguishing bacteria found two groups index markers. Metabolomic analysis revealed expression of metabolites, such as etiocholanolone, testosterone sulfate, indole-3-pyruvic acid, corresponding signaling pathways, especially those involved tryptophan metabolism, fatty acid degradation steroid hormone biosynthesis, also changed significantly. Correlation positive associations between group-enriched Bacteroides abundance etiocholanolone sulfate abundances; particular, correlated positively BMD. Importantly, tryptophan-indole metabolism pathway was uniquely metabolized by bacteria-derived tnaA gene, predicted which significantly control group, strongly gene. Discussion Our indicated a clear difference Specifically altered derived indicating potential modifiable factors therapeutic targets preventing osteoporosis.

Language: Английский

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Curcumin Ameliorated Glucocorticoid-Induced Osteoporosis While Modulating the Gut Microbiota and Serum Metabolome

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Glucocorticoid-induced osteoporosis (GIOP) is the leading cause of secondary osteoporosis. Recently, "bone-gut axis" theory has linked bone development with gut microbial diversity, community composition, and metabolites. Curcumin, a well-studied polyphenol, shows potential in mitigating loss Alendronate, standard therapeutic agent for osteoporosis, serves as positive control this investigation. The study demonstrates potency curcumin reducing restoring mineral density, enhancing trabecular parameters notably through increased number, volume, thickness reduced marrow cavity size. Gut microbiome sequencing revealed that both alendronate treatments similarly enhanced diversity altered microbiota increasing beneficial bacteria (Akkermansia_muciniphila, Dubosiella_sp910585105, Ruminococcus_sp910584195) while harmful (Treponema_D_sp910584475 Duncaniella_sp910584825). Furthermore, significant changes serum levels metabolites including raffinose, ursolic acid, spermidine, inosine, hypoxanthine, thiamine, pantothenic acid were observed post-treatment or alendronate. Importantly, these microorganisms negatively correlated inflammatory cytokines. In conclusion, holds promise use against GIOP by modulating metabolome well systemic inflammation.

Language: Английский

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The gut microbial composition in polycystic ovary syndrome with hyperandrogenemia and its association with steroid hormones

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: May 30, 2024

Polycystic ovary syndrome (PCOS) is characterized by excess androgens, ovulatory dysfunction, and polycystic ovaries. The mechanisms underlying metabolic disorders in PCOS remain elusive, hampering therapeutic development. Enhanced health correlates with increased microbiota gene content microbial diversity. We aimed to explore the impact of gut serum steroids on regulation associated androgen excess.

Language: Английский

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From gut to bone: deciphering the impact of gut microbiota on osteoporosis pathogenesis and management

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 25, 2024

Osteoporosis (OP) is characterized by decreased bone mineral density (BMD) and increased fracture risk, poses a significant global health burden. Recent research has shed light on the bidirectional relationship between gut microbiota (GM) health, presenting novel avenue for understanding OP pathogenesis developing targeted therapeutic interventions. This review provides comprehensive overview of GM-bone axis, exploring impact GM development management. We elucidate established risk factors OP, delve into diversity functional changes in OP. Furthermore, we examine experimental evidence clinical observations linking alterations composition or function with variations BMD risk. Mechanistic insights microbial mediators such as metabolites products, are discussed. Therapeutic implications, including GM-targeted interventions dietary strategies, also explored. Finally, identify future directions challenges translating these findings practice.

Language: Английский

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2′-Fucosyllactose ameliorates aging-related osteoporosis by restoring gut microbial and innate immune homeostasis

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: July 10, 2024

Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on processes of bone formation. Nonetheless, a notable gap exists in literature concerning bibliometric analysis trends at nexus metabolism.

Language: Английский

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Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies

Osteoporosis International, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

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Anti-osteoporosis effect of Prunus humilis fruit on ovariectomized rats via modulating the function of bone metabolism

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104416 - 104416

Published: May 25, 2024

Language: Английский

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