The ameliorative effects and underlying mechanisms of Lactobacillus plantarum on glyoxal-induced cytotoxicity DOI
Mu Yang,

Siyu Guo,

Fangyi Chen

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105806 - 105806

Published: Dec. 1, 2024

Language: Английский

Goji-Derived Exosomes-Like Nanoparticles Ameliorate Alcohol-Induced Acute Liver Injury by modulating gut microbiota and metabolites DOI
Lin Guo, Qiao Ding,

Wenhui Duan

et al.

Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals DOI Creative Commons
Lian Xiao, Mingyu Shi, Ying Liang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 305 - 305

Published: Feb. 29, 2024

Unconventional feed, which is abundant in China, contains anti-nutritional factors and toxins; however, these can be greatly reduced with microbial fermentation, thus improving the nutrient content of enhancing animal appetites, ultimately significantly intestinal health growth performance animals. When oxidative stress occurs, fermented feed effectively reduce damage caused by to gastrointestinal tract, accelerate removal abnormalities, improve ability resist stress, ensure efficient production This review introduces application unconventional production, expounds upon function animals symptoms, so as provide a theoretical reference for development antioxidative reduction.

Language: Английский

Citations

10
Hepatoprotective potential of four fruit extracts rich in different structural flavonoids against alcohol-induced liver injury via gut microbiota-liver axis DOI
Yunyi Chen,

Hanbing Ma,

Jiaojiao Liang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140460 - 140460

Published: July 15, 2024

Language: Английский

Citations

10
The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways DOI Creative Commons
Chenyu Jiang, Z. J. Chen, Weilin Liao

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(11), P. 1531 - 1531

Published: May 31, 2024

Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus widely consumed and highly nutritious. Moreover, their constituents have attracted attention for health-promoting properties. In East Asia, there three varieties of (

Language: Английский

Citations

7
The potential of lactic acid bacteria in fermented herbs-derived food products DOI

Haisu Shi,

Yulian Zhao,

Weiming Wang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104714 - 104714

Published: July 9, 2024

Language: Английский

Citations

7
Galangin Prevents Against Ethanol-Induced Intestinal Barrier Dysfunction and NLRP3 Inflammasome Activation via NF-κB/MAPK Signaling Pathways in Mice and Caco-2 Cells DOI

Yanan Zhao,

Бин Ли, Jiang Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 11, 2024

The potential of natural phytochemicals in addressing ethanol-related public safety concerns has been garnering attention. Galangin, a potent flavonoid renowned for its antioxidative and anti-inflammatory characteristics, is derived from the galanga plant, propolis bees. Here, we documented effects galangin on ethanol-stimulated intestinal tight junction damage investigated protective mechanism both vivo vitro models, which not extensively investigated. Our results revealed that efficaciously mitigated ethanol-induced intestine injury dysfunction barrier. Concurrently, significantly counteracted upregulation NLRP3 inflammasome-associated proteins activated mitogen-activated protein kinase (MAPK) nuclear factor kappa-B (NF-κB) signaling pathways mouse colon Caco-2 cells. Interestingly, similar to galangin, inhibitors MAPKs NF-κB p65 reduced inflammasome activation damage. To sum up, our showed blocks perturbation barrier via NF-κB/MAPK pathways.

Language: Английский

Citations

6
Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health DOI Creative Commons

Charumathi Anbalagan,

Sangeetha Kadapakkam Nandabalan,

Pavithra Sankar

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 344 - 344

Published: March 13, 2024

The eubiotic state of the gut microbiota is primarily brought about by various probiotic species that colonize gut. It becoming very clear probiotic-metabolite mixtures in luminal milieu central establishing cross-kingdom signalling networks to maintain gut-multi-organ axes health. Culturally, different fermented foods and beverages have been regional staples since ancient times, are known be enriched with probiotics. However, variations including environment, staple food source (prebiotics), fermentation methods, among other factors, influence fermenting species. Fermented rice water (FRW), an economical, easy make, simple beverage a rich synbiotics. Therefore, consumption allows for intake variety region-specific live secondary metabolites (postbiotics) present such symbiotic may also contribute toward maintaining normal intestinal cellular functions. In this study, we highlight as consumed their form hold promise alleviating gut-related diseases. Our results show overnight cooked edible enables growth bacterial belonging Lactic Acid Bacteria group (Leuconostoc lactis, Weisella confusa, cibacria, Lactococcus lactococcus taiwanensis, Lactobacillus fermentum, nagelii, delbrueckii ssp. indicus). Metabolomic analysis over two-nights identified more than 200 postbiotic metabolites. postbiotics contributing energy metabolism, gut-multiorgan axes, microbial paraprobiotics (~10 h) compared water. Functional via gene expression studies nutrient absorption (mct-1 mct-2) barrier integrity (occludin zo-1) reveals significant upregulation these genes upon FRW treatment HT29 colon cells. This study first-of-its-kind demonstrate proof-of-principle naturally positively modulates colonocyte

Language: Английский

Citations

5
Protective Effects of Schizochytrium Microalgal Fatty Acids on Alcoholic Liver Disease: A Network Pharmacology and In Vivo Study DOI

Cailin Luo,

Li Tian,

Yangmin Wen

et al.

Assay and Drug Development Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

This study aimed to elucidate the hepatoprotective mechanisms of microalgal fatty acids (MFA) from Schizochytrium against alcoholic liver disease (ALD) through network pharmacology and in vivo analysis. Network molecular docking methodologies were employed predict potential MFA ALD. To substantiate these predictions, an acute injury mouse model was utilized assess impact on serum levels alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate (AST), total protein (TP), albumin (ALB). Additionally, histopathology expression phosphatidylinositol 3 kinase (PI3K) B (AKT) evaluated. Seven active ingredients 53 targets (including 7 core targets) for ALD treatment identified MFA. Kyoto Encyclopedia Genes Genomes pathway analyses indicated that seven are implicated various biological pathways, notably those associated with cancer, viral infections, PI3K/AKT signaling pathway. Furthermore, studies demonstrated docosahexaenoic acid docosapentaenoic exhibited strong binding affinity crucial targets. Animal experiments administration significantly decreased AST, ALT, ALP, while increasing ALB TP mice injury. Moreover, ameliorated tissue pathology markedly down-regulated PI3K AKT proteins liver. These results suggest may possess therapeutic by targeting multiple its likely involving inhibition

Language: Английский

Citations

0
The Preparation of Black Goji Berry Enzyme and Its Therapeutic Effect on Alcoholic Liver Injury in Mice DOI Creative Commons

K Wang,

Z Zhang,

Wenge Xu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 523 - 523

Published: Feb. 6, 2025

This study aimed to prepare a black goji berry enzyme (BGBE) using high acyl gellan gum as substitute for aqueous slurry, followed by fermentation with Saccharomyces cerevisiae (SC) 48 h, pasteurization, and subsequent Lactobacillus plantarum h obtain the optimal BGBE sample. The anthocyanin content in vitro antioxidant activity were significantly enhanced. primary objective of this was evaluate potential therapeutic effect on alcoholic liver injury (ALD) mice. An animal model established, levels alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG), total cholesterol (TC), malondialdehyde (MDA), superoxide dismutase (SOD), alcohol dehydrogenase (ADH), aldehyde (ALDH) serum analyzed. Furthermore, histopathological examination performed hematoxylin–eosin staining. results indicated that improved condition mice, markedly reducing ALT, AST, TG, TC, hepatic MDA (p < 0.05), while increasing SOD, ADH, ALDH 0.05). appears be associated its properties.

Language: Английский

Citations

0
Lacticaseibacillus paracasei E10-Fermented Goji Juice: A Novel Approach to Mitigate High-Fat Diet-Induced Chronic Liver Injury and Optimize Gut Health in Mice DOI
Qian Ding,

Qingbin Chen,

Yilin Ren

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106445 - 106445

Published: March 1, 2025

Language: Английский

Citations

0