Co-housing with Tibetan chickens improved the resistance of Arbor Acres chickens to Salmonella enterica serovar Enteritidis infection by altering their gut microbiota composition

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 3, 2025

Abstract Background Salmonella enterica serovar Enteritidis ( S . Enteritidis) is a global foodborne pathogen that poses significant threat to human health, with poultry being the primary reservoir host. Therefore, addressing infections in crucial protect health and industry. In this study, we investigated effect of co-housing Arbor Acres (AA) chickens, commercial breed susceptible Enteritidis, Tibetan local resistant infection, on resistance latter pathogen. Results Ninety-six 1-day-old chickens 96 AA were divided into chicken housed alone group n = 48), an co-housed (48 birds from each for 2 cages). All provided same diet, experimental period lasted 14 d. At d 7, all infected samples collected at 1-, 3-, 7-day-post-infection. We found body weight significantly increased when 1- 3-day-post-infection P < 0.05). addition, cecal load was reduced 7-day-post-infection Furthermore, inflammatory response decreased, as evidenced by decreased expression pro-inflammatory cytokines NOS2 , TNF-α IL-8 IL-1β IFN-γ their tonsils Co-housing height villi number goblet cells 0.05), well claudin-1 tight junction protein, jejunum chickens. Further analysis revealed altered gut microbiota composition chickens; specifically, relative abundances harmful microbes, such Intestinimonas Oscillibacter Tuzzerella Anaerotruncus Paludicola, Anaerofilum Conclusions Our findings indicate enhanced infection without compromising This study provides novel approach control practical production.

Language: Английский

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Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5208 - 5222

Published: Feb. 24, 2025

Cognitive disorders such as Alzheimer's disease (AD) are highly prevalent and place heavy burdens on society. Neuroinflammation is a driver of cognitive impairment, with no effective drugs. Indole 3-propionic acid (IPA) tryptophan metabolite mainly produced byClostridium sporogenes, which exhibits multiple functions, including antioxidant, anti-inflammatory, antiaging, neuroprotective properties. However, the restorative effects molecular mechanisms IPA in impairment remain to be investigated. In this study, we found that reduced LPS-induced apoptosis oxidative damage HT22 cells decreased inflammation BV2 cells. Besides, promoted neurogenesis, inhibited glial cell activation, maintained integrity BBB intestinal barrier, remodeled gut microbiota, thereby alleviating memory cognitively impaired mice. At mechanistic level, RAGE-JAK2-STAT3 signaling pathway thus ameliorated neuroinflammation. Interestingly, Colivelin TFA, an activator JAK2-STAT3 signaling, partially reversed neurorestorative IPA. conclusion, ameliorates neuroinflammation deficits via inhibition pathway. Thus, may potential drug for treatment disorders.

Language: Английский

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Sensory quality and Metabolomic fingerprinting of Lacticaseibacillus paracasei-derived fermented soymilk beverages: Impact of starter strain and storage

Food Chemistry, Journal Year: 2025, Volume and Issue: 482, P. 144147 - 144147

Published: April 2, 2025

Language: Английский

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Evaluation of Sensory Properties and Short-Chain Fatty Acid Production in Fermented Soymilk on Addition of Fructooligosaccharides and Raffinose Family of Oligosaccharides

Fermentation, Journal Year: 2025, Volume and Issue: 11(4), P. 194 - 194

Published: April 5, 2025

High potential is attributed to the concomitant use of probiotics and prebiotics in a single food product, called “synbiotics”, where prebiotic component distinctly favours growth activity probiotic microbes. This study implemented detailed comparison between effect Fructooligosaccharides (FOSs) Raffinose family oligosaccharides (RFOs) on viable count bacteria, hydrolysis into monosaccharides, biosynthesis short-chain fatty acids sensory attributes soymilk fermented with 1% (v/v) co-cultures Lacticaseibacillus rhamnosus JCM1136 Weissella confusa 30082b. The highest 1.21 × 109 CFU/mL was observed 3% RFOs added as source compared MRS broth (3.21 108) FOS (6.2 107 CFU/mL) when replaced against glucose broth. stachyose were extensively metabolised (4.75 1.28-fold decrease, respectively) supplemented soymilk, there an increase glucose, galactose, fructose (2.36, 1.55, 2.76-fold, FOS. Synbiotic showed 99-fold methyl propionate, while one butyrate. acceptability based for 2% + table sugar vanillin (7.87 ± 0.52) high mouth feel, product consistency, taste, flavour. shows that simultaneous administration soy bacteria like FOSs enhance synergistic interaction them, which upgraded nutritional quality synbiotic soymilk.

Language: Английский

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Probiotics with ABCG2 expression ability and gut microbiota homeostasis exhibit anti-hyperuricemia potential by promoting uric acid excretion

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106814 - 106814

Published: April 11, 2025

Language: Английский

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Pleurocinus ostreatus Polysaccharide Alleviates Cyclophosphamide-Induced Immunosuppression through the Gut Microbiome, Metabolome, and JAK/STAT1 Signaling Pathway

Foods, Journal Year: 2024, Volume and Issue: 13(17), P. 2679 - 2679

Published: Aug. 25, 2024

This study investigated the structure of

Language: Английский

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Fermented soy products: A review of bioactives for health from fermentation to functionality

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 15, 2024

Abstract The increasing prevalence of metabolic diseases and the global drive toward achieving Sustainable Development Goals (SDGs) underscore need for sustainable, nutrient‐dense foods. Soybeans ( Glycine max ), a critical crop, offer promising solutions; however, their predominant use as animal feed raises concerns regarding food security environmental sustainability. Fermented soy products—including tempeh, natto, miso—are rich in bioactive compounds such peptides isoflavones, which potential therapeutic effects hold cultural nutritional significance. These fermented products provide profiles with unique health‐promoting properties. This review critically examines generated through fermentation, focusing on bioconversion pathways gastrointestinal tract implications human health. Recent consumer demand novel ingredients additional biological benefits has fueled research into advanced extraction techniques, enhancing functional applications from these soy‐based products. further explores innovations methods that improve yield sustainability, reinforcing applicability interventions. originality this lies its in‐depth exploration alongside latest sustainable designed to optimize use. Future should aim refine fermentation processes, investigate synergistic microbial interactions, develop environmentally production methods. efforts have position essential contributors systems, addressing both public health needs.

Language: Английский

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Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

European Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 128, P. 10 - 19

Published: July 27, 2024

Language: Английский

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Effect of co-fermentation with non-digestible oligosaccharides on the quality of fermented goat milk: Physicochemical properties, microbial composition, and small intestine modulations in mice

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104878 - 104878

Published: Aug. 6, 2024

Language: Английский

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Raw and heat-treated quinoa protein protects against glucose metabolism disorders in high-fat diet (HFD)-induced mice by reshaping gut microbiota and fecal metabolic profiles

Food & Function, Journal Year: 2024, Volume and Issue: 15(18), P. 9409 - 9419

Published: Jan. 1, 2024

Plant-based proteins have received considerable global attention due to their nutritional value and potential health effects. As a high-quality plant protein, the hypoglycemic effect of quinoa protein its mechanism not been fully elucidated. In present study, we compared effects raw (RP-quinoa) heat-treated (HP-quinoa) further explored mechanisms using multi-omics analysis based on gut microbiota fecal metabolic profiles in HFD-fed mice. Our results showed that both RP-quinoa HP-quinoa effectively improved glucose metabolism protected against alterations induced by chronic HFD. addition, increased relative abundance beneficial bacteria such as

Language: Английский

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