The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
An
efficient
one-step
protocol
has
been
developed
to
access
a
variety
of
2-amino-1,3-benzoxazine
derivatives
via
tetrabutylammonium
iodide-mediated
electrochemical
desulfurative
cyclization
isothiocyanates
and
2-aminobenzyl
alcohols.
The
reaction
proceeds
through
cycle
involving
in
situ
iodine
generation,
cyclization,
iodide
regeneration,
efficiently
forming
intermolecular
C–O
C–N
bonds
affording
2-amino-1,3-benzoxazines
moderate
excellent
yields.
practical
utility
this
strategy
is
evidenced
by
its
broad
substrate
scope,
good
functional
group
compatibility,
scalability
gram-scale
synthesis,
metal-
oxidant-free
conditions.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(10), P. 5824 - 5831
Published: Jan. 1, 2024
An
electrochemical
oxidation-induced
amination
of
simple
alkylarenes
with
sulfoximines
as
a
nitrogen
source
and
5,6-dimethyl-1
H
-benzo[
d
]imidazole
catalyst
was
developed.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(32), P. 5978 - 5983
Published: Aug. 7, 2023
An
electrochemical
oxidation-induced
cyclization
of
ortho-alkyl-substituted
azobenzenes
has
been
developed.
The
direct
benzylic
C-H
functionalization
with
respect
to
could
proceed
in
the
absence
any
catalyst
or
external
chemical
oxidant
afford
a
number
2H-indazole
derivatives
moderate
good
yields.
This
protocol
enables
reuse
byproduct
same
2H-indazoles,
thus
significantly
reducing
pollution
discharge
synthetic
chemistry.
Green Synthesis and Catalysis,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 1, 2023
The
synthesis
of
4-halo-functionalized
pyrazoles
by
electrochemical
cascade
reactions
between
N,N-dimethyl
enaminones
and
proper
hydrazine
reagents
in
the
presence
a
halogen
source
is
realized
at
room
temperature.
work
provides
tunable
efficient
accesses
to
4-chloro-
4-bromopyrazoles
aqueous
THF
(tetrahydrofuran)
without
using
any
transition
metal
reagent.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(30), P. 6324 - 6329
Published: July 22, 2024
Direct
functionalization
of
azobenzenes
provides
an
approach
to
obtaining
valuable
molecules
in
synthetic
chemistry.
However,
efficient
method
for
the
cleavage
N═N
bond
azobenzenes,
which
is
a
key
process
this
transformation,
still
lacking.
We
herein
disclose
electrochemical
reduction-induced
cyclization
with
aldehydes
via
cleavage.
This
proceeds
well
absence
any
transition
metals
or
external
chemical
oxidants,
leading
formation
N-protected
benzimidazoles
moderate
good
yields.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Comprehensive
Summary
The
N–H
methylsulfoxidation
of
sulfoximines
using
DMSO
as
a
methylsulfinyl
source,
induced
by
electrochemistry,
has
been
developed.
This
method
is
the
first
example
an
electrochemical
reaction
in
which
serves
source.
Unlike
previous
reactions
involving
substrate,
exclusively
proceed
via
radical
mechanisms,
this
follows
S‐cation
pathway.
A
wide
range
N
‐methylsulfinyl
were
successfully
obtained.
Asian Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
In
this
work
we
present
a
new
method
for
indazole
synthesis
through
the
unexpected
rearrangement
of
various
7‐nitroisatins
during
reaction
with
hydrazine
hydrate.
The
pyrazole
cycle
is
formed
via
direct
metal‐free
C−H
amination.
We
demonstrate
limitations
discovered
approach
and
several
accessible
methods
functionalization
compounds
to
obtain
novel
derivatives.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 1, 2025
The
development
of
green
and
efficient
methods
for
the
construction
N-heterocyclic
frameworks
has
attracted
considerable
attention
in
organic
synthesis.
In
this
work,
an
electrochemical
oxidative
cyclization
primary
amines
synthesis
benzimidazole,
benzothiazole,
quinazolinone,
quinoxaline
been
developed.
This
catalyst-
oxidant-free
strategy
demonstrates
good
functional
group
tolerance,
up
to
87%
yield
N-based
heterocycles
undivided
cell
under
open-air
conditions
is
easy
scale
up.
