Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(38), P. 7811 - 7816
Published: Jan. 1, 2024
A solvent-free, operationally simple, and chemoselective mechanochemical method for
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(3), P. 1657 - 1668
Published: Jan. 19, 2024
Herein, we report a heterogeneous visible light-driven preparation of α-alkylated glycine derivatives. This approach employed β-ketoenamine-linked covalent organic framework (2D-COF-4) as the photocatalyst and N-hydroxy phthalimide (NHPI) esters alkyl radical sources. Numerous derivatives, including dipeptides, were precisely efficiently alkylated under reaction conditions. Based on excellent photoactivity compatibility 2D-COF-4, this alkylation could proceed flexibly in green solvent (ethanol) without any other additives. The fruitfully recycled with simple workup procedure, revealing high ecoscale value low environmental factor (E-factor).
Language: Английский
Citations
4
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(10), P. 5890 - 5899
Published: Jan. 1, 2024
A novel approach utilizing the polymer-assisted grinding (POLAG) technique to facilitate regioselective oxidative Heck coupling of aryl boronic acids with electronically unbiased olefins under solvent-free conditions was presented.
Language: Английский
Citations
4
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(11), P. 6570 - 6577
Published: Jan. 1, 2024
Ethanol-assisted grinding effectively facilitated aerobic asymmetric cross-dehydrogenative coupling of glycine esters/amides with ketones/aldehydes, deploying reusable chiral amine/NaCl for rapid synthesis α-alkyl α-glycine derivatives.
Language: Английский
Citations
3
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(26)
Published: Jan. 31, 2024
Although the 3 d transition-metal catalyzed C-H functionalization have been extensively employed to promote formation of valuable carbon-carbon bonds, persistent problems, including use sensitive Grignard reagents and rigorous operations (solvent-drying, inert gas protection, metal pre-activation RMgX addition rate control), still leave great room for further development sustainable methodologies. Herein, we report a mechanochemical technology toward in-situ preparation highly organomagnesium reagents, thus building two general catalytic platforms that enables regioselective arylation alkylation indoles with wide variety halides (including those containing post transformable functionalities heteroaromatic rings). This strategy also brings unique reactivity high step-economy in producing functionalized N-free indole products.
Language: Английский
Citations
2
Green Chemistry, Journal Year: 2023, Volume and Issue: 25(20), P. 8124 - 8133
Published: Jan. 1, 2023
Environmentally friendly acid-catalyzed 2-alkynyl-ynamides (N–Csp) bond cleavage, alkyne migration and stereospecific functionalization with anisole derivatives for the synthesis of challenging indole scaffolds in 5–10 minutes.
Language: Английский
Citations
6
Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 11(1), P. 127 - 134
Published: Nov. 10, 2023
A mechanochemical iron-catalyzed asymmetric oxidative coupling between glycines and β-ketoesters has been disclosed, utilizing t -BuOH to improve the enantioselectivity stabilize iminium intermediate via intensified hydrogen bond interactions.
Language: Английский
Citations
4
RSC Mechanochemistry, Journal Year: 2024, Volume and Issue: 1(4), P. 367 - 374
Published: Jan. 1, 2024
A new three-step mechano-synthesis method starts with 4-bromoquinoline, uses Suzuki–Miyaura, Minisci C–H alkylation, and oxidation Heck coupling reactions, leading to rapid eco-friendly synthesis of the key Pitavastatin intermediate.
Language: Английский
Citations
1
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Abstract Organic synthesis has historically relied on solution‐phase, polar transformations to forge new bonds. However, this paradigm is evolving, propelled by the rapid evolution of radical chemistry. Additionally, organic witnessing a simultaneous resurgence in mechanochemistry, formation bonds solid‐state, further contributing shift status quo. The aforementioned advances chemistry have predominantly occurred solution phase, while majority mechanochemical feature transformations. Herein, we discuss rapidly advancing area synthesis: reactions. Solid‐state reactions offer improved green metrics, better reaction outcomes, and access intermediates products that are difficult or impossible reach solution. This review explores these context small molecule synthesis, from early findings current state‐of‐the‐art, underscoring pivotal role solid‐state likely play sustainable chemical synthesis.
Language: Английский
Citations
1
Pharmaceutical Fronts, Journal Year: 2024, Volume and Issue: 06(01), P. e9 - e19
Published: March 1, 2024
Abstract The organosulfur frameworks containing C–S bonds are important structural motifs in various biologically active molecules and functional materials. In this regard, transition-metal catalysis using chemical oxidants to prime reactions has emerged as the most common method, however, is prone several side such dimerization overoxidation. recent years, organic electrosynthesis become a hot topic due its eco-friendly mild process which costly catalysts toxic could be replaced by electrons. This perspective summarized recently developed bond protocols, discussing highlighting reaction features, substrate scope, well application pharmaceuticals, underlying mechanisms. study helps development of electrochemical process-enabled construction future.
Language: Английский
Citations
0
Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(38), P. 7811 - 7816
Published: Jan. 1, 2024
A solvent-free, operationally simple, and chemoselective mechanochemical method for
Language: Английский
Citations
0