Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Epicatechin
(EC)-based
derivatives
have
garnered
significant
attention
for
their
powerful
antioxidant,
anti-inflammatory,
anticancer,
and
antibacterial
properties,
all
of
which
are
attributed
to
the
phenolic
hydroxyl
groups
in
structure.
These
compounds
promising
regenerative
medicine,
particularly
as
bioactive
components
scaffolds.
This
review
provides
an
in-depth
analysis
mechanisms
by
EC-based
materials
enhance
tissue
repair,
examining
application
various
scaffold
forms,
such
hydrogels,
nanoparticles,
nanofibers.
study
also
addresses
challenges
stability
bioavailability
associated
with
ECs
proposes
encapsulation
techniques
overcome
these
barriers.
The
potential
clinical
benefits
medicine
role
fostering
advancements
engineering
discussed,
making
this
a
valuable
resource
guiding
future
studies
on
integration
into
practice.
Flexible
wearable
electronic
devices
have
garnered
significant
interest
due
to
their
inherent
properties,
serving
as
replacements
for
traditional
rigid
metal
conductors
in
personal
healthcare
monitoring,
human
motion
detection,
and
sensory
skin
applications.
Here,
we
report
a
preparation
strategy
self-adhesive,
ultrahigh
stretchable
DGel
based
on
poly(acrylic
acid)
(PAA).
The
resulting
exhibits
high
tensile
strength
(approximately
2.16
MPa)
an
stretchability
5622.14%).
More
importantly,
these
meticulously
designed
DES
gels
demonstrate
signal
recognition
capabilities
under
strains
ranging
from
1
500%.
also
shows
excellent
cyclic
stability
durability
(5000
cycles
at
100%
strain),
exhibiting
superior
electromechanical
performance
strain
sensor.
of
is
attributed
the
synergistic
effects
chemical
physical
cross-linking
within
gel.
Additionally,
can
be
effortlessly
assembled
into
sensors.
By
integration
flexible
sensing
with
deep
learning,
fabricated
touch
system
achieves
identification
accuracy
up
99.33%.
This
advancement
offers
new
insights
designing
novel
variety
applications,
including
tissue
engineering,
sensing,
devices.
Small,
Journal Year:
2024,
Volume and Issue:
20(46)
Published: Aug. 6, 2024
Abstract
The
strong
anti‐inflammatory
effect
of
methylprednisolone
(MP)
is
a
necessary
treatment
for
various
severe
cases
including
acute
spinal
cord
injury
(SCI).
However,
concerns
have
been
raised
regarding
adverse
effects
from
MP,
which
also
severely
limits
its
clinical
application.
Natural
polyphenols,
due
to
their
rich
phenolic
hydroxyl
chemical
properties,
can
form
dynamic
structures
without
additional
modification,
achieving
targeted
enrichment
and
drug
release
at
the
disease
lesion,
making
them
highly
promising
carrier.
Considering
application
challenges
natural
polyphenolic
platform
employed
efficient
delivery
reducing
systemic
side
effects.
Both
in
vitro
SCI
models
demonstrated
polyphenols
multiple
advantages
as
carriers
delivering
MP:
(1)
Achieved
maximum
injured
site
2
h
post‐administration,
met
desires
early
diseases;
(2)
Traceless
MP;
(3)
Reducing
effects;
(4)
Endowed
system
with
new
antioxidative
an
aspect
that
needs
be
addressed
diseases
treatment.
This
study
highlighted
prospect
robust
based
on
successfully
overcome
barrier
MP
treatment,
providing
possibility
widespread
Small Science,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Nov. 21, 2024
Human-machine
interface
(HMI)
electrodes
enable
interactions
between
humans
and
bioelectronic
devices
by
facilitating
electrical
stimulation
recording
neural
activity.
However,
reconciling
the
soft,
hydrated
nature
of
living
human
tissues
with
rigid,
dry
properties
synthetic
electronic
systems
is
inherently
challenging.
Overcoming
these
significant
differences,
which
critical
for
developing
compatible,
effective,
stable
interfaces,
has
become
a
key
research
area
in
materials
science
technology.
Recently,
hydrogels
have
gained
prominence
use
HMI
because
are
similar
to
can
be
tuned
through
incorporation
nanofillers.
This
review
examines
functional
requirements
highlights
recent
progress
development
polyphenol-mediated
multifunctional
hydrogel-based
bioelectronics.
Furthermore,
aspects
such
as
mussel-inspired
adhesion,
underlying
mechanisms,
tissue-matching
mechanical
properties,
electrochemical
performance,
biocompatibility,
biofouling
resistance,
stability
under
physiological
conditions,
anti-inflammatory,
antioxidant
discussed.
Finally,
applications
bioelectronics
further
perspectives
outlined.
Advances
hydrogel
expected
facilitate
unprecedented
integration
biological
devices,
potentially
revolutionizing
various
biomedical
fields
enhancing
capabilities
performance
devices.
Conductive
hydrogels
have
garnered
significant
attention
in
the
realm
of
future
flexible
electronic
devices
due
to
their
properties
such
as
flexibility,
electrical
conductivity,
frost
resistance,
and
biocompatibility.
However,
integration
numerous
functional
applications
biomedical
field
still
presents
notable
challenges.
In
this
research,
a
rigid
hard-structured
network
was
formed
by
cross-linking
gallic
acid
grafted
chitosan
(CS–GA)
tannic
(TA)
with
poly(vinyl
alcohol)
(PVA)
through
physical
freezing.
The
noncovalent
hydrogen
bonding
during
freezing
thawing
process
facilitated
formation
microcrystalline
domains
amorphous
hydrogel
system.
Functional
proteins
from
eggshell
membrane
were
cross-linked
tetra-armed
poly(ethylene
glycol)
maleimide
(4am-PEG-MAL)
via
thiol-olefin
click
chemistry,
lysozyme
incorporated
into
an
antibacterial
component
nucleophilic
substitution
reaction.
These
chemical
methods
resulted
soft-structured
that
enhanced
mechanical
(maximum
stress
2.15
MPa
elongation
605%).
use
ionic
liquids/ethylene
glycol/water
(ILs/EG/H2O)
ternary
solvents
instead
single
solvent
not
only
provided
resistance
but
also
imparted
excellent
conductivity
(0.37
±
0.04
S/m).
Notably,
organohydrogel
showed
good
antimicrobial
biocompatibility
effective
providing
emergency
cooling
after
fireworks
burns
promoting
wet
healing
broken
skin
minimize
scarring.
field,
multifunctional
can
serve
wearable
device
monitor
movement
amplitude
wounds
real-time,
offering
novel
approach
deep
learning-assisted
wound
healing.
nature
biological
promising
applications.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 20, 2024
Abstract
The
construction
and
application
of
smart
hydrogels
often
involve
balancing
the
conflicting
relationship
between
stability
dynamics.
Imine
bond,
as
a
type
dynamic
chemical
bonding,
is
commonly
used
in
diverse
since
it
can
effectively
achieve
response
to
some
external
stimuli.
However,
its
poor
thermodynamic
leads
limited
crosslinking
density
easy
degradation
water
biofluids.
To
address
this
critical
issue,
series
model
prepared
with
highly
stimuli
responsiveness
via
iminoboronate
gelation
aminoglycosides
8‐arm
PEG
terminated
2‐acetylphenylboronic
acid
pinacol
ester
[(
pin
)‐APBA].
Note
that
presence
esters,
electron‐donating
agents
hydrophobic
couplers
large
steric
hindrance,
keep
five‐membered
ring
intact
protect
nitrogen‐boron
(N─B)
coordination
bond
from
molecules,
offering
resistance
feature
hydrogels.
And
rapid
gels
(e.g.,
acid,
H
2
O
unhindered
amines)
further
confirmed
their
nature,
allowing
on‐demand
release
satisfactory
antibacterial
effect.
This
chemistry‐based
strategy
offer
new
opportunities
toward
stable
various
applications
many
fields.
Gels,
Journal Year:
2024,
Volume and Issue:
10(9), P. 601 - 601
Published: Sept. 20, 2024
Polyepicatechin
(PEC)
in
a
hydrogel
has
previously
shown
promise
enhancing
physiological
properties
and
scaffold
preparation.
However,
it
remains
unclear
whether
PEC-based
fibers
can
be
applied
skin
tissue
engineering
(STE).
This
study
aimed
to
synthesize
characterize
electrospun
PEC
physical
gels
polylactic
acid
(PLA)
scaffolds
(PLAloadedPECsub)
for
potential
use
as
constructs
with
human
dermal
fibroblasts
(HDFs).
was
produced
through
enzymatic
polymerization,
confirmed
by
Fourier
transform
infrared
(FTIR)
spectroscopy.
Scanning
electron
microscopy
(SEM)
demonstrated
the
feasibility
of
producing
PLAloadedPECsub
electrospinning.
The
metabolic
activity
viability
HDFs
cocultured
indicate
that
is
promising
STE.
