Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139376 - 139376
Published: July 23, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105662 - 105662
Published: April 16, 2024
Language: Английский
Citations
8
Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329
Published: Aug. 5, 2024
Language: Английский
Citations
8
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 212, P. 115387 - 115387
Published: Sept. 1, 2024
Language: Английский
Citations
6
Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.
Language: Английский
Citations
5
International Journal of Breast Cancer, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Breast cancer stands as the utmost prevalent malignancy in women, impacting epithelial tissue of breast and often displaying resistance to effective treatment due its diverse molecular histological features. Current modalities may exhibit decreasing efficacy over time can lead disease progression. The mitochondria, a crucial organelle responsible for cellular metabolism energy supply, stand highly sensitive both heat reactive oxygen species, presenting an assuring target photodynamic photothermal therapies (PTTs) cure. employment nanodrug carriers combination deliveries holds promise addressing challenges related drug degradation off-target toxicity. By circumventing reticuloendothelial system, nanocarriers bolster drug's bioavailability at intended site ensure controlled codelivery multiple drugs, thereby maintaining normal pharmacokinetic features regular pharmacodynamic characteristics different therapeutic mechanisms. precision this innovative technology have revolutionized delivery, substantially enhancing effectiveness. In pursuit targeting mitochondrial modifications cells, various such therapy (PDT), PTT, chemodynamic (CDT) been explored. These improved efficiency mitochondria-targeted their advantageous properties minimal toxicity, noninvasiveness, reduced resistance, safer profile. Our review article provides exhaustive overview alterations environment BC, impact on BC development, potential targets treatment, nanotherapeutic approaches limitations these approaches.
Language: Английский
Citations
0
Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 325 - 336
Published: Jan. 16, 2025
Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.
Language: Английский
Citations
0
Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Abnormal cancer metabolism causes hypoxia and immunosuppression, limiting the anti-tumor efficacy of radiotherapy. Herein, we report a positively charged, mitochondria-targeted nanoscale metal-organic layer conjugated with 3-bromopyruvate (BP), BP/Hf12-Ir, for metabolic reprogramming radiosensitization. BP/Hf12-Ir disrupts oxidative phosphorylation glycolysis, reducing energy production alleviating to enhance radiotherapy immunity. in combination X-ray irradiation inhibits tumor growth by 95% prevents lung metastasis mouse models. When further combined immune checkpoint blockade, this treatment induces robust immunity, achieving 98% inhibition.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10796 - 10796
Published: Oct. 8, 2024
Cancer treatment continues to be a substantial problem due tumor complexities and persistence, demanding novel therapeutic techniques. This review investigates the synergistic potential of combining photodynamic therapy (PDT) tailored medication delivery technologies increase mitochondrial toxicity improve cancer outcomes. PDT induces selective cellular damage death by activating photosensitizers (PS) with certain wavelengths light. However, PDT's efficacy can hampered issues such as poor light penetration lack selectivity. To overcome these challenges, targeted drug systems have emerged promising technique for precisely delivering medicines cells while avoiding off-target effects. We investigate how targeting damage, which is critical causing cell death. The combination method seeks capitalize on advantages both modalities: activation specific delivery. current preclinical clinical evidence supporting this therapy, focusing case studies experimental models. also addresses safety, distribution efficiency, resistance mechanisms, costs. prospects further research include advances in agents technology, focus personalized treatment. In conclusion, provides frontier ability limits open way more effective, treatments.
Language: Английский
Citations
3
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 525, P. 216306 - 216306
Published: Nov. 22, 2024
Language: Английский
Citations
2
Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1888 - 1888
Published: Nov. 18, 2024
Gliomas are the most common primary brain tumors, representing approximately 28% of all central nervous system tumors. These tumors characterized by rapid progression and show a median survival 18 months. The therapeutic options consist surgical resection followed radiotherapy chemotherapy. Despite multidisciplinary approach biomolecular role targeted therapies, progression-free is 6-8 incomplete tumor compliance with treatment due to several factors such as presence blood-brain barrier, numerous pathways involved in transformation, intra-tumoral mutations. Among these, interaction between mutations genes bio-energetic metabolism functional response has become protagonist studies. In this scenario, main played mitochondria, cellular organelles delimited double membrane containing their own DNA (mtDNA), which participates processes regulation metabolism, proliferation, apoptosis also source energy production. Therefore, it understood that mitochondrion, specifically its alteration, leading figure including acquisition mitochondrial cells subsequent identification so-called mitochondria-related (MRGs), both (mutation Complex I) structural (mutations III/IV), have been seen play an important metabolic reprogramming increased resistance apoptosis, tumorigenesis. This demonstrates these alterations could not only intrinsic biology but extrinsic one associated response. We aim summarize dysfunction interactions present gliomas how they might impact prognosis.
Language: Английский
Citations
1