Prospects of Innovative Therapeutics in Combating the COVID-19 Pandemic DOI
Thamby Rajah Mahendran, Binsin Cynthia, Ramesh Thevendran

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

NHCs silver complexes as potential antimicrobial agents DOI Creative Commons
Stephen R. Isbel, Siddappa A. Patil, Alejandro Bugarin

et al.

Inorganica Chimica Acta, Journal Year: 2023, Volume and Issue: 563, P. 121899 - 121899

Published: Dec. 27, 2023

Citations

18
Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects DOI Creative Commons
Igor V. Esarev,

Bianka Karge,

Haoxuan Zeng

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(5), P. 1753 - 1766

Published: April 12, 2024

The antibacterial activity of silver species is well-established; however, their mechanism action has not been adequately explored. Furthermore, issues low-molecular compounds with cytotoxicity, stability, and solubility hamper progress to drug leads. We have investigated N-heterocyclic carbene (NHC) halido complexes [(NHC)AgX, X = Cl, Br, I] as a promising new type organometallics. Spectroscopic studies conductometry established higher stability for the iodide ligands, nephelometry indicated that could be administered in solutions physiological chloride levels. showed broad spectrum strong against pathogenic Gram-negative bacteria. However, there was no significant Gram-positive strains. Further clarified tryptone yeast extract, components culture media, were responsible this lack activity. reduction biofilm formation inhibition both glutathione thioredoxin reductases IC50 values nanomolar range confirmed selected compounds. In addition improved physicochemical properties, ligands did display cytotoxic effects, unlike other complexes. summary, NHC secondary represent useful scaffold nontoxic organometallics properties distinct based on reductases.

Language: Английский

Citations

6
Synthesis, characterisation and biological evaluation of novel bisimidazolium mononuclear and dinuclear silver(I)-N-heterocyclic carbene complexes with long N-alkyl chains DOI Creative Commons

Jia Ming Khe,

Zhijack Fong, Wai-Leng Lee

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1009, P. 123076 - 123076

Published: March 2, 2024

Current drug research has been focusing on silver N-heterocyclic carbene (NHC) complex. Its metal-ligand bonds are stabilised by the strong-electron donor nature of NHC, ultimately increasing its antimicrobial properties. A series imidazolium salts and their corresponding Ag(I)-NHC complexes with different NHC side chains in terms alkyl chain length mono/biscarbene functionalities have successfully synthesised, characterised, evaluated for potential activities. It was shown that long aliphatic N-1/N-3 bisimidazolium ligands possess promising bioactivities general, minimum inhibitory concentration (MIC) against microbes ranging from 0.12 to 7.81 µg/mL selected six Gram-positive bacterial strains (Staphylococcus aureus Enterococcus faecalis), two Gram-negative bacteria (Escherichia coli Shigella flexneri) fungal (Candida albicans) 2-7d & Ag-2-7d. found compounds biscarbene structures (6d Ag-6d) less toxic effects immortalised human keratinocyte (HaCaT) cells. However, it must be noted effect HaCaT is higher among (Ag-4d than (4d 6d) general. Hence, variation chains, number centres respective cytotoxic provide insights into future modification towards enhanced activities minimal effects.

Language: Английский

Citations

5
In vitro and in silico anticancer potential of binuclear silver (I) N-heterocyclic carbene (NHCs) complexes: Investigation of interaction with surfactants DOI
Rizwan Ashraf, Sumia Akram, Mohamed El‐Naggar

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 571, P. 122181 - 122181

Published: June 6, 2024

Language: Английский

Citations

3
Antimicrobial Activity of Anionic Bis(N-Heterocyclic Carbene) Silver Complexes DOI Creative Commons
Carlos J. Carrasco, Francisco Montilla, Eduardo Villalobo

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4608 - 4608

Published: Sept. 27, 2024

The antimicrobial properties of a series anionic bis(carbene) silver complexes Na

Language: Английский

Citations

3
Naphthalene-bridged binucleating N-heterocyclic carbene ligand: Theoretical structure analysis, investigation of coinage metal complexation, and anticancer effects DOI
Mahdi Cheraghi, Mohammad Reza Yousefshahi, Reza Taghizadeh-Tabarsi

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 175, P. 114145 - 114145

Published: Feb. 17, 2025

Language: Английский

Citations

0
In situ preparation of imidazolyl ionic liquid molecular cation moisture-resistant A3Bi2I9 perovskite crystals for efficient photocatalytic water purification and hydrogen production DOI
Yaoyao Wang, Yuqing Wang, Chunfeng Wang

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 117218 - 117218

Published: May 1, 2025

Language: Английский

Citations

0
The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes DOI Creative Commons
Ahmet Duran Ataş,

Zübeyda Akın-Polat,

Derya Gül Gülpınar

et al.

JBIC Journal of Biological Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 29(5), P. 499 - 509

Published: June 26, 2024

Encephalitozoon intestinalis is an opportunistic microsporidian parasite that primarily infects immunocompromised individuals, such as those with HIV/AIDS or undergoing organ transplantation. Leishmaniasis responsible for parasitic infections, particularly in developing countries. The disease has not been effectively controlled due to the lack of effective vaccine and affordable treatment options. Current options E. infection leishmaniasis are limited often associated adverse side effects. There no previous study literature on antimicrosporidial activities Ag(I)-N-heterocyclic carbene compounds. In this study, vitro previously synthesized complexes were evaluated using spores cultured human renal epithelial cell lines (HEK-293). Inhibition replication was determined by spore counting. addition, effects compounds Leishmania major promastigotes assessed measuring metabolic activity viability a tetrazolium reaction. Statistical analysis performed determine significant differences between treated control groups. Our results showed growth L. inhibited tested concentration-dependent manner. A decrease observed at highest concentrations. These suggest have potential anti-microsporidial anti-leishmanial activity. Further research required elucidate underlying mechanisms action evaluate efficacy animal models clinical trials.

Language: Английский

Citations

2
Mechanistic Insights into Targeting SARS-CoV-2 Papain-like Protease in the Evolution and Management of COVID-19 DOI Creative Commons

Nonjabulo Ntombikhona Magwaza,

Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja

et al.

BioChem, Journal Year: 2024, Volume and Issue: 4(3), P. 268 - 299

Published: Sept. 23, 2024

The COVID-19 pandemic, instigated by the emergence of novel coronavirus, SARS-CoV-2, created an incomparable global health crisis. Due to its highly virulent nature, identifying potential therapeutic agents against this lethal virus is crucial. PLpro a key protein involved in viral polyprotein processing and immune system evasion, making it prime target for development antiviral drugs combat COVID-19. To expedite search candidates, review delved into computational studies. Recent investigations have harnessed methods identify promising inhibitors targeting PLpro, aiming suppress activity. Molecular docking techniques were employed researchers explore binding sites within catalytic region PLpro. elucidates functional structural properties SARS-CoV-2 underscoring significance pathogenicity replication. Through comprehensive all-atom molecular dynamics (MD) simulations, stability drug–PLpro complexes was assessed, providing dynamic insights their interactions. By evaluating energy estimates from MD stable with identified. This offers overview drug/lead candidates discovered thus far using diverse silico methodologies, encompassing drug repurposing, structure-based, ligand-based virtual screenings. Additionally, identified are listed based on chemical structures meticulously examined according various parameters, such as estimated free (ΔG), types intermolecular interactions, PLpro–ligand complexes, determined outcomes simulations. Underscoring pivotal role battle COVID-19, establishes robust foundation integrating modeling, insights. continual imperative improvement existing exploring compounds remains paramount efforts evolution management hinge symbiotic relationship between experimental validation, interdisciplinary synergy crucial endeavor.

Language: Английский

Citations

2
Synthesis, structures, electrochemical characterizations, theoretical and anticancer studies of Pd(II)-, Pt(II)- NHC complexes DOI Open Access

Ambarish Mondal,

Subhadarshinee Behera,

Hemanta K. Kisan

et al.

Inorganica Chimica Acta, Journal Year: 2023, Volume and Issue: 559, P. 121796 - 121796

Published: Oct. 10, 2023

Language: Английский

Citations

4