Molbank,
Journal Year:
2025,
Volume and Issue:
2025(1), P. M1968 - M1968
Published: Feb. 13, 2025
Herein,
we
present
the
synthesis
of
N-(4-methoxyphenethyl)-2-oxo-2H-chromene-3-carboxamide.
The
synthesized
compound
has
been
thoroughly
characterized
using
melting
point
analysis,
1H-
and
13C-NMR
spectroscopy,
infrared
mass
spectrometry.
comprehensive
data
obtained
from
these
techniques
confirm
successful
structural
integrity
newly
molecule.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Despite
the
widespread
ortho-functionalization
of
cyclic
diaryliodoniums
in
organic
chemistry,
corresponding
meta-functionalization
is
less
explored.
Herein,
we
report
a
practical
meta-selective
activation
hypervalent
iodoniums
for
synthesis
4-amino
coumarin
derivatives
broad
functional
group
tolerance
and
environmentally
friendly
manner.
The
practicability
this
protocol
was
further
highlighted
by
late-stage
modification
some
common
pharmaceuticals
natural
products.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: March 27, 2025
Cancer
remains
a
significant
global
health
challenge
with
limited
therapeutic
success,
prompting
the
need
for
innovative
treatment
strategies.
This
study
investigates
anticancer
potential
of
nano-encapsulated
metal
derivatives
(CS-QM2)
using
zebrafish
model
chemically
induced
cellular
neoplasia.
Characterization
CS-QM2
nanoparticles
revealed
successful
synthesis
high
entrapment
efficiency
and
enhanced
drug
release
under
acidic
conditions.
Zebrafish
embryos
exposed
to
7,12-Dimethylbenz[a]anthracene
(DMBA)
exhibited
malformations,
macrophage
accumulation,
abnormal
tissue
growth,
which
were
markedly
reduced
by
treatment.
significantly
increases
intracellular
ROS,
resulting
in
higher
LPO
induces
apoptosis
neoplasm
tissues.
Furthermore,
alters
tumor
microenvironment,
reducing
accumulation
decreasing
neutral
lipid
droplets,
disrupting
TAM
metabolic
support
limiting
their
protumorigenic
activities.
Biochemical
assays
demonstrated
restored
activities
antioxidant
enzymes
SOD,
CAT,
GSH.
Gene
expression
analysis
showed
upregulation
suppressor
genes
(cas3,
p53)
downregulation
inflammatory
(cox-2,
nf-kb).
Histological
assessment
SEM
confirmed
occurrence
abnormalities.
These
findings
suggest
that
effectively
inhibit
growth
modulate
microenvironment
through
oxidative
stress
induction
gene
regulation.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(7), P. 1592 - 1592
Published: April 2, 2025
Several
new
coumarin–isoxazole–pyridine
hybrids
were
synthesized
through
a
1,3-dipolar
cycloaddition
reaction
of
nitrile
oxides,
prepared
in
situ
from
pyridine
aldehyde
oximes,
with
propargyloxy-
or
propargylaminocoumarins
moderate-to-good
yields.
Synthetic
modifications
applied
using
(diacetoxyiodo)benzene
(PIDA)
at
room
temperature,
microwave
irradiation,
tert-butyl
nitrite
(TBN)
under
reflux.
Coumarin,
isoxazole,
and
groups
selected
for
hybridization
one
molecule
due
to
their
biological
impact
inhibit
lipid
peroxidation
an
enzyme
implicated
inflammation.
Preliminary
vitro
screening
tests
lipoxygenase
(LOX)
inhibition
anti-lipid
the
performed.
A
discussion
on
structure–activity
relationship
is
presented.
Compounds
12b
13a
found
be
potent
LOX
inhibitors
IC50
5
μΜ
10
μΜ,
respectively,
while
presented
high
(90.4%)
peroxidation.
Furthermore,
exhibited
moderate-to-low
anticancer
activities
HeLa,
HT-29,
H1437
cancer
cells.
The Journal of Physical Chemistry Letters,
Journal Year:
2024,
Volume and Issue:
15(43), P. 10866 - 10872
Published: Oct. 23, 2024
Most
of
the
traditional
fluorescent
molecules
have
advantages
high
fluorescence
quantum
yield,
good
stability,
and
excellent
structural
adjustability,
but
they
exhibit
characteristics
quenching
caused
by
aggregation,
which
restricts
their
application
in
aqueous
solutions
or
solids.
The
luminescence
properties
photosensitive
potential
aggregation-induced
emission
(AIE)
materials
a
condensed
state
made
them
widely
concerned
scientific
research
field,
so
it
is
very
challenging
to
regulate
transformation
aggregation-caused
(ACQ)
fluorophores
into
AIE
fluorophores.
In
this
study,
coumarin
fluorophore
was
used
as
matrix.
After
conjugating
triphenylamine
group,
triphenylphosphine
cation
linked
through
alkyl
chain
obtain
molecular
probe
NCTPP
with
characteristic,
water
solubility,
mitochondrial
green
light
imaging,
chemotherapy
photodynamic
therapy
capabilities.
As
far
we
know,
first
time
that
photosensitivity
imparted
ACQ-AIE
conversion
method.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(34), P. 24671 - 24686
Published: Jan. 1, 2024
A
new
series
of
amino
acid
derivatives
linked
to
coumarin
has
been
synthesized
as
CK2
inhibitors.
Compound
7c
outperforms
doxorubicin
in
cell
lines,
while
compound
5b
shows
superior
inhibition
compared
roscovetine.
