Ultrasound-Targeted Microbubble Destruction Enhances the Inhibitory Effect of Sonodynamic Therapy against Hepatocellular Carcinoma DOI Creative Commons

Huajing Yang,

Yunfeng Qu,

Yuhang Tian

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(52), P. 51253 - 51263

Published: Dec. 18, 2024

Purpose: To assess the anticancer effect of microbubbles (MBs) in combination with sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy (SDT) for vitro and vivo treatment hepatocellular carcinoma (HCC). Methods: HepG2 cells were used experiments. Reactive oxygen species (ROS) production was detected using 2′,7′-dichlorodihydrofluorescein diacetate singlet sensor green solution, respectively. Cytotoxicity evaluated a Cell Counting Kit 8 assay calcein AM/PI double-staining method. Annexin V-FITC/PI staining employed to analyze rate cell apoptosis. surface calreticulin exposure, high mobility group box 1 release, adenosine triphosphate secretion measured detect immunogenic death (ICD). The further assessed Hepa1–6 tumor-bearing mice. Results: Compared SDT alone, ROS MBs + enhanced 1.2-fold (p < 0.0001). cytotoxic DVDMS-mediated on concentration-dependent, additional application increased cytotoxicity. Additionally, augmented SDT-induced apoptosis from 33.26 ± 13.48 72.95 7.95% 0.01). Notably, our results demonstrated that can enhance ICD. In experiments, combined significantly reduced tumor volume, negligible differences mouse body weight. Furthermore, effectively tissue destruction. Conclusion: present study indicates markedly improve effects HCC.

Language: Английский

Polymer-based nanodrugs enhance sonodynamic therapy through epigenetic reprogramming of the immunosuppressive tumor microenvironment DOI
Lin Yu, Lulu Gao, Bin Liang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 125 - 137

Published: Feb. 5, 2025

Language: Английский

Citations

1

Design strategies and applications of cyanine dyes in phototherapy DOI
Jie Yuan, Han‐xue Yang,

Wenhui Huang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An overview of cyanine dye-based phototherapy agents, including the design strategies, relationships between molecular structures and properties, as well applications in photodynamic therapy, photothermal multimodal combined therapy.

Language: Английский

Citations

6

Harnessing Ultrasonic Technologies to Treat Staphylococcus Aureus Skin Infections DOI Creative Commons
John Hulme

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512

Published: Jan. 23, 2025

The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).

Language: Английский

Citations

0

Sonodynamic therapy-based dual blockade of glucose metabolism strategy for pancreatic cancer treatment DOI
Ling Wang, Jiarui Li,

Yinuo Zheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160180 - 160180

Published: Feb. 1, 2025

Language: Английский

Citations

0

State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches DOI Creative Commons
Bruno Agustín Cesca,

K. Martin,

Matías Daniel Caverzán

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, poses a significant therapeutic challenge due to its highly invasive nature resistance conventional therapies, including surgery, chemotherapy, radiotherapy. Despite advances in standard treatments, patient survival remains limited, requiring exploration of innovative strategies. Photodynamic therapy (PDT) has emerged as promising approach, leveraging light-sensitive photosensitizers (PSs), molecular oxygen, specific light wavelengths generate reactive oxygen species (ROS) that selectively induce tumor cell death. Originally developed for skin cancer, PDT evolved target more complex malignancies, GBM. The refinement second- third-generation PS, coupled with advancements nanotechnology, significantly improved PDT's selectivity, bioavailability, efficacy. Moreover, combination targeted therapy, immunotherapy, among other modalities, shown potential enhancing outcomes. This review provides comprehensive analysis preclinical clinical applications GBM, detailing mechanisms action, evolution novel combinatory strategies optimize treatment However, several challenges remain, overcoming GBM-associated hypoxia, PS delivery across blood-brain barrier, mitigating mechanisms. integration genetic insight, alongside cutting-edge nanotechnology-based systems, may revolutionize GBM treatment, offering new prospects quality life.

Language: Английский

Citations

0

Advances and Perspectives on Bioelectronic and Atomic Nanogenerators for Anticancer Therapy DOI Creative Commons
Massimo Mariello

Nanoenergy Advances, Journal Year: 2025, Volume and Issue: 5(2), P. 4 - 4

Published: March 31, 2025

Nowadays, due to improvements in living standards, more attention is reserved all-around disease prevention and health care. In particular, research efforts have been made for developing novel methods treatments anti-cancer therapy. Self-powered nanogenerators emerged recent years as an attractive cost-effective technology harvest energy or biosensing applications. Bioelectronic can be used inducing tissue recovery treating human illness through electrical stimulation. However, there still a lack of comprehensive cognitive assessment these devices platforms, especially regarding which requirements must satisfied working principles transduction adopted effectively the body. This review covers most advances bioelectronic therapy, based on different transducing strategies (photodynamic drug delivery, stimulation, atomic nanogenerators, etc.), potential mechanisms repair promotion are discussed. The prospective challenges finally summarized with indication future outlook.

Language: Английский

Citations

0

The role of manganese-based MRI contrast agents for cancer theranostics: Where do we stand in 2025? DOI Creative Commons
Lingyan Zhang,

Shubham Roy,

Bing Guo

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(9), P. 4147 - 4174

Published: March 15, 2025

Magnetic resonance imaging (MRI) guidance in the realm of anticancer therapy is crucial to visualize spread tumors deep tissues, accumulate therapeutics, and trigger them for precise therapy. Recent studies bridge this gap by integrating MRI contrast agents (CAs) with different therapeutic regimes a better outcome. In context, manganese-based materials hold great potential owing their T1/T2 dual-modal MR-relaxation, less toxicity, other capabilities such as chemodynamic therapy, immunotherapy, etc., which have gained increasing interest among researchers medical professionals. This work offers timely update on last three years Mn-based MRI-guided theranostic applications, including chemotherapy, photo therapies, sonodynamic radiotherapy against cancer. Further, several combinatory therapies surgical intersections also been summarized light guidance. The design rationale these has discussed understand existing challenges plausible outcomes shortly. Herein, we dive into stimulus-based probes pH, temperature, etc. show unexplored Mn-complexes domain. state-of-the-art review will guide innovations CAs expedite safer modules clinical translation.

Language: Английский

Citations

0

A nanodrug loading indocyanine green and metformin dually alleviating tumor hypoxia for enhanced chemodynamic/sonodynamic therapy DOI
Ziying Zhang,

Weishen Zeng,

Ning Guo

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 341 - 355

Published: Nov. 19, 2024

Language: Английский

Citations

3

Exploration of Alkyne-Based Multilayered 3D Polymers and Oligomers: Subtle Aggregation-Induced Emission, Chromium(VI) Ion Detection, and Chiral Properties Characterization DOI Creative Commons
Sai Zhang, Qingzheng Xu,

Xiuyuan Qin

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5641 - 5641

Published: Nov. 28, 2024

This study investigates the synthesis and characterization of alkyne-based multilayered three-dimensional (3D) polymers, which exhibit a subtle aggregation-induced emission (AIE) phenomenon. The polymers demonstrate significant potential as fluorescent probes for selective detection chromium (VI) ions (Cr6⁺), showcasing their utility in environmental sensing applications. Additionally, circular dichroism (CD) spectra reveal pronounced cotton effect, indicative chiral properties, while scanning electron microscopy (SEM) dynamic light scatting (DLS) analysis distinctive rock-like surface morphology Cr6+ sensitive anti-aggregation. These findings highlight multifunctional capabilities 3D suggesting applicability both fluorescence-based materials science. insights gained from this research contribute to development advanced with tailored optical properties monitoring other practical

Language: Английский

Citations

2

In Vitro Study of Sonodynamic Therapy Using Gemcitabine-Loaded PEG-Gold Nanoparticles Against MCF-7 Breast Cancer Cells DOI
Ali Salarvand, Ahmad Shanei, Seyed Hossein Hejazi

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(3), P. 2117 - 2130

Published: June 20, 2024

Language: Английский

Citations

1