Alginate-based hydrogels mediated biomedical applications: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135019 - 135019

Published: Aug. 28, 2024

Language: Английский

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A multifunctional hydrogel with mild photothermal antibacterial and antioxidant properties based on quercetin and dopamine-coated zinc oxide nanoparticles for healing bacteria-infected wound

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154518 - 154518

Published: Aug. 5, 2024

Language: Английский

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Chemo-Photothermal Therapy on Breast Cancer Cells in a 3D Coculture Hydrogel Model with In Situ Embedded Polydopamine Nanoparticle

ACS Applied Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Breast cancer is one of the most common cancers in world. Surgery preferred treatment for this cancer, but risk local recurrence and metastasis remaining cells after surgery still a significant concern. A coculture 3D model based on dopamine-grafted alginate (Alg-DA) containing different polydopamine nanoparticles (PDA NPs) presented work breast cell therapy. The PDA NPs were grown situ hydrogels to fabricate ADHG-PDAN-x hydrogels, which x indicates NP content. human line MDA-MB-231 primary foreskin fibroblast (HFF) cocultured closely resemble vivo tumor microenvironment. hydrogel models treated by applying an anticancer drug, docetaxel (chemotherapy), near-infrared (NIR) irradiation using laser with 808 nm wavelength power 1 W/cm2 (photothermal therapy), combination both methods (chemo-photothermal therapy). results unveiled increased effect chemo-photothermal therapy 67.4% eradication cancerous cells, while only chemotherapy photothermal showed 48.4% 57.8% rates, respectively. This therapeutic method can potentially prevent growth be used eliminate residual cells.

Language: Английский

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Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123144 - 123144

Published: Jan. 25, 2025

Language: Английский

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Engineered MXene Biomaterials for Regenerative Medicine

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

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Photothermal/Photodynamic Synergistic Antibacterial Hydrogel Dressing with pH/Glucose Dual Responsive Pirfenidone Release for Diabetic Foot Ulcers

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Diabetic foot ulcers (DFU) are notoriously challenging to heal due severe infection, excessive inflammation, and difficulty in angiogenesis. In response these problems, first, a pH/glucose dual‐responsive hydrogel dressing (HPC) is constructed using dual dynamic crosslinking through Schiff base phenylboronate ester between m‐aminophenylboronic acid adipic dihydrazide bifunctionalized hyaluronic (AHP) oxidized chondroitin sulfate (OCS). Then, polydopamine‐reduced graphene oxide compounded glycine‐modified fullerene (GPC) with photothermal/photodynamic synergistic antibacterial properties the drug pirfenidone (PFD) pro‐angiogenesis suppress inflammatory loaded into above HPC hydrogel. Based on of base/phenylboronate pH/glucose, HPC/GPC/PFD (HPCG/PFD) can accelerate release PFD, thereby improving inflammation angiogenesis DFU. addition, provided good on‐demand removal self‐healing performance, while GPC brought tissue adhesion, antioxidation, electrical conductivity The rheology, morphology, mechanical properties, swelling, degradation, biocompatibility have been well verified. Finally, DFU model rats, this promote wound repair by reducing infection accelerating closure, enhancing epidermal regeneration, collagen deposition, angiogenesis, showing promoting effect diabetic healing.

Language: Английский

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A Self-Powered Casein Hydrogel E-Dressing with Synergistic Photothermal Therapy, Electrical Stimulation, and Antibacterial Effects for Chronic Wound Management

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

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A Semi-Interpenetrating Network Hydrogel with Excellent Photothermal Antibacterial and ROS Scavenging Activities for MRSA-Infected Wounds

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

The prolonged infection of bacteria at the wound site may lead to serious physical problems. Herein, a multifunctional macroporous hydrogel with superior photothermal antibacterial and ROS scavenging activity (denoted as M-XG gel) was designed for treatment MRSA-infected wounds. gels are composed embedding Prussian blue nanoparticles (PBNPs) converters chelating ferric ions xanthan gum (XG) dopamine (DA) form semipermeable network. introduction DA occupies cross-link sites ions, further increasing pore size (200-500 μm open macropores) endowing ideal adhesion. increase in PBNPs formed promising equilibrium gel identical structures toughened mechanical performance. metal ligands between catechols, well unique response PBNPs, endow hydrogels fast stable near-infrared (NIR) conversion efficiency (48%). In SD rat trauma model, wounds treated group had completely closed after 14 days, effectively controlling bacterial accelerating angiogenesis collagen deposition, synergistically promoting infected healing. Therefore, semi-interpenetrating network demonstrates its great potential tissue engineering.

Language: Английский

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A smart drug delivery microgel system with phased intervention capabilities and dual physical state of use promotes healing of diabetic infected wounds

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Effectively managing infected diabetic wounds involves the elimination of bacteria, neutralization reactive oxygen species (ROS), suppression inflammation, and induction angiogenesis. This study describes development a multifunctional hyaluronic acid (HA)-based microgel system capable serving as either an injectable wet or dry microspheres (MSs). After initially engineering Fe2+/tea polyphenol (TP) metal-polyphenol network (MPN)-functionalized HAMA MS, these particles were found to suppress inflammation facilitate ROS scavenging. A deferoxamine (DFO)-loaded zinc-based metal-organic framework (ZIF-8@DFO) was then coated using phenylboronic (PBA)-functionalized ε-polylysine (PPL) produce PPZD nanoparticles with antibacterial pro-angiogenic properties. The dynamic loading into MPN-functionalized MS (MMS) via boron ester bonds yielded pH/ROS-responsive (MMS@PPZD). PPL coating endowed prepared materials antimicrobial properties while mitigating cytotoxic effects resulting from rapid release Zn2+ DFO in acidic micro-environments. showed superior biocompatibility phased intervention activities aligned various stages wound healing process vitro vivo. Specifically, under conditions, sequentially released TP, PL, Zn2+, DFO, enabling effective scavenging, suppressing exhibiting activity, inducing Overall, this environmentally-responsive, multifunctional, versatile offers significant promise for management.

Language: Английский

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