Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 738, P. 150935 - 150935
Published: Nov. 1, 2024
Language: Английский
Natural Product Reports, Journal Year: 2024, Volume and Issue: 41(2), P. 251 - 272
Published: Jan. 1, 2024
Covering: 2016 to 2023The synthetic chemistry community is always in pursuit of efficient routes natural products. Among the many available general strategies, skeletal reorganization, which involves formation, cleavage, and migration C-C C-heteroatom bonds, stands out as a particularly useful approach for assembly molecular skeletons. In addition, it allows late-stage modification products quick access other family members or unnatural derivatives. This review summarizes syntheses steroid, terpenoid, alkaloid that have been achieved by means this strategy past eight years. Our goal illustrate strategy's potency reveal spectacular human ingenuity demonstrated its use development.
Language: Английский
Citations
10
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 19, 2025
Terpenoids are the largest family of natural products but relatively rare in bacteria. Genome mining reveals widespread prevalence terpene synthases, enzymes responsible for constructing hydrocarbon skeletons, Here, we show that 125 (37%) 334 synthases from 8 phyla, 17 classes, and 83 genera bacteria active as diterpene synthases. Isolation structural elucidation 28 diterpenes 31 reveal three previously unreported skeletons other organisms with unknown biosynthetic pathways, known to best our knowledge not seen bacteria, or new stereochemical isomers diterpenes. We also identify type I myxobacteria cyanobacteria. This study will help discover products, advance studies terpenoid biosynthesis enzymology, provide model systems probe ecological roles terpenes.
Language: Английский
Citations
1
World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)
Published: Jan. 30, 2025
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: March 31, 2025
The sustainable production of valuable compounds using microbial cell factories is an effective approach, yet further metabolic engineering strategies are needed to enhance their biosynthetic potential. Recent studies suggest that RNA modifications can influence cellular metabolism, but role in remains largely unexplored. squalene and lupeol different yeast strains was detected by gas chromatography-mass spectrometry (GC-MS) equipment. Transcriptomic analysis performed identify changes associated with the epigenetic modification. transcriptional translational expression targeted genes were determined real-time quantitative polymerase chain reaction western blotting, respectively. mRNA stability measured decay assay. In this study, overexpression Trm8 Trm82 complex, mediating tRNA 7-methylguanosine (m7G) modification yeast, significantly increased CEN.PK2-1C. Transcriptome indicated Trm8/Trm82 upregulated levels involved amino acid synthesis, glycolysis, tricarboxylic cycle, enhanced upstream acetyl-CoA biosynthesis, might be responsible for promoted biosynthesis squalene. Further investigation demonstrated complex could increase engineered yeast. These findings indicate m7G regulate central metabolism terpenoid biosynthesis. This study provides new insights into as a potential strategy improving high-value compounds.
Language: Английский
Citations
0
Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2024, Volume and Issue: unknown, P. 447 - 475
Published: Jan. 1, 2024
Language: Английский
Citations
3
RSC Chemical Biology, Journal Year: 2024, Volume and Issue: 5(10), P. 1010 - 1016
Published: Jan. 1, 2024
The chemical logic associated with assembly of many bacterial terpenoids remains poorly understood. We focused our efforts on the early-stage biosynthesis phenalinolactone diterpenoids, demonstrating that
Language: Английский
Citations
3
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Based on rich sulfur-involving chemical transformations, a novel spokewise synthetic strategy, subclass of the collective strategies, has been developed to concisely synthesize four erythrina alkaloids through single-step transformation from common precursor. Moreover, six additional have also synthesized by subsequent 1-2 steps transformations. The current approaches provide valuable platform for total syntheses and
Language: Английский
Citations
3
Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review explores recent insights into the roles and enzymatic mechanisms of canonical non-canonical tailoring enzymes in shaping modifying terpene hydrocarbon scaffolds during bacterial biosynthesis.
Language: Английский
Citations
0
Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
In this article, we review the key processes contributing to chemical diversity of terpenes in red algae. We present knowledge gaps and perspectives for heterologous biosynthesis.
Language: Английский
Citations
0
Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108547 - 108547
Published: Feb. 1, 2025
Language: Английский
Citations
0