Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41246 - e41246
Published: Dec. 18, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5862 - 5903
Published: Jan. 1, 2024
Schematic of the immunomodulatory approaches for tipping balance towards anti-cancer immunity. This image was created with BioRender.com.
Language: Английский
Citations
11
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109562 - 109562
Published: Jan. 26, 2024
Language: Английский
Citations
8
Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)
Published: Jan. 26, 2024
This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables synergistic integration multiple treatment strategies. In particular, has enabled combination immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. each regimen, nanocarriers play multifaceted roles by achieving targeted codelivery different therapeutics individual modality. offers new paradigms guide precision medicine treatment. Immunotherapy alone unlikely achieve personalized cancer, are needed future. To overcome technical bottlenecks realize precise regulation tumor microenvironment treatment, it crucial develop novel nanosystems integrated sensing, targeting, functionalities.
Language: Английский
Citations
6
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 6, 2024
Inspired by the concept of "natural camouflage," biomimetic drug delivery systems have emerged to address limitations traditional synthetic nanocarriers, such as poor targeting, susceptibility identification and clearance, inadequate biocompatibility, low permeability, systemic toxicity. Biomimetic nanocarriers retain proteins, nucleic acids, other components parent cells. They not only facilitate but also serve communication media inhibit tumor This paper delves into mechanisms between various cell-derived cells, microenvironment, well their applications in delivery. In addition, additional capabilities conferred on modified targeting environmental responsiveness, are outlined. Finally, we propose future development directions for hoping inspire researchers design efforts ultimately achieve clinical translation.
Language: Английский
Citations
4
Journal of Otolaryngology - Head and Neck Surgery, Journal Year: 2025, Volume and Issue: 54
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomaterials Advances, Journal Year: 2025, Volume and Issue: 170, P. 214234 - 214234
Published: Feb. 14, 2025
This systematic review aims to summarize the development of erythrocyte membrane vesicles (EMVs) as drug delivery carriers, with a focus on elucidating their fate in terms biodistribution and pharmacokinetics preclinical studies. The PubMed database was systematically reviewed search for original peer-reviewed published studies use EMVs findings, following PRISMA guidelines. A total 142 articles matched selection criteria were included review. For each study, parameters extracted: type active pharmaceutical ingredient (API) encapsulated into EMVs, EMVs-API formulation method final particle size, surface modifications targeting, cell lines animal models used crucial treatment data, data finally, where applicable, about circulation time blood half-life. size did not vary significantly among different methods. complete list is provided. Circulation times half-life grouped per type. most commonly type, BALB/c mice, average EMV-API calculated be 10.4 h, all cases, up 10-fold increase observed compared that free API. Surface drastically change but improve target tissue accumulation. critical weaknesses analysed identified. Key points future are provided fill current knowledge gaps quality publications.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2024, Volume and Issue: 18(7), P. 5632 - 5646
Published: Feb. 12, 2024
Physical stimulation with mild heat possesses the notable ability to induce immunomodulation within tumor microenvironment (TME). It transforms immunosuppressive TME into an immune-active state, making tumors more receptive immune checkpoint inhibitor (ICI) therapy. Transient receptor potential vanilloid 1 (TRPV1), which can be activated by heat, holds these alterations in TME. However, achieving precise temperature control while protecting neighboring tissues remains a significant challenge when using external sources. Taking inspiration from sensation elicited capsaicin-containing products activating TRPV1, this study employs capsaicin chemically stimulate imitating immunomodulatory benefits akin those induced heat. This involves developing glutathione (GSH)-responsive prodrug micelle system deliver and ICI (BMS202) concurrently. Following intravenous administration, micelles accumulate at site through enhanced permeability retention effect. Within GSH-rich TME, disintegrate release BMS202. The released activates TRPV1 expressed enhancing programmed death ligand expression on cell surfaces promoting T recruitment rendering it immunologically active. Meanwhile, liberated BMS202 blocks checkpoints cells cells, recruited ultimately eradicating tumors. innovative strategy represents comprehensive approach fine-tune significantly amplifying effectiveness of cancer immunotherapy exploiting pathway enabling situ
Language: Английский
Citations
3
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4381 - 4402
Published: Aug. 1, 2023
Introduction: As the special modality of cell death, immunogenic death (ICD) could activate immune response. Phototherapy in combination with chemotherapy (CT) is a particularly efficient tumor ICD inducing method that overcome defects monotherapies. Methods: In this study, new dual stimuli-responsive micelles were designed and prepared for imaging-guided mitochondrion-targeted photothermal/photodynamic/CT therapy through ICD. A dual-sensitive methoxy-polyethylene glycol-SS-poly(L-γ-glutamylglutamine)-SS-IR780 (mPEG-SS-PGG-SS-IR780) polymer was synthesized by grafting IR780 biodegradable di-carboxyl PGG as backbone, mPEG-SS-PGG-SS-IR780/paclitaxel (mPEG-SS-PGG-SS-IR780/PTXL MCs) encapsulating PTXL hydrophobic core. Results: In-vivo -vitro results demonstrated three-mode inhibited growth enhanced therapeutic efficacy immunotherapy. The mPEG-SS-PGG-SS-IR780/PTXL MCs able to facilitate endocytosis nanoparticles. They also capable promoting disintegration accelerating release. induced mitochondrial dysfunction directly targeting mitochondria, considering thermo- reactive oxygen species (ROS) sensitivity mitochondria. Furthermore, play diagnostic roles via imaging capabilities. Conclusion: summary, study formulated high-efficiency nanoscale platform great potential combined tumors Keywords: photothermal/photodynamic/chemo therapy, dual-stimuli-responsive, poly(amino acid)s micelles, mitochondria
Language: Английский
Citations
4
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Aug. 5, 2024
Nanoparticle-based photothermal therapy (PTT) has emerged as a promising approach in tumor treatment due to its high selectivity and low invasiveness. However, the penetration of near-infrared light (NIR) is limited, leading it fails induce damage deep-seated cells within tissue. Additionally, inefficient uptake nanoparticles by results suboptimal outcomes for PTT. In this study, we utilized adhesive properties material, polydopamine (PDA), which can successfully load photosensitizer indocyanine green (ICG) chemotherapeutic drug doxorubicin (DOX) achieve chemotherapy synergy (PDA/DOX&ICG), aiming compensate defects single treatment. To extending blood circulation time PDA/DOX&ICG nanoparticles, evading clearance body immune system achieving targeted delivery tissues, protective envelopment was created using erythrocyte membranes modified with folate acid (FA-EM). After reaching tissue, obtained FA-EM@PDA/DOX&ICG specific bind receptors on surface cells, improve behavior release loaded DOX ICG response unique microenvironment. ICG, typical photosensitizer, significantly enhances conversion performance thus inducing damage. vitro vivo experimental demonstrated that coordinated NIR not only effectively inhibits growth, but also exhibits superior biocompatibility, mitigating DOX-induced tissue
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138620 - 138620
Published: Dec. 13, 2024
Language: Английский
Citations
1