Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
Abstract
The
increasing
occurrence
of
infections
caused
by
multidrug‐resistant
(MDR)
bacteria
drives
the
need
for
new
antibacterial
drugs.
Due
to
current
lack
antibiotic
discovery
and
development,
strategies
fight
MDR
are
urgently
needed.
Efforts
develop
adjuvants
increase
effectiveness
existing
antibiotics
design
delivery
systems
essential
address
this
issue.
Here,
a
bioinspired
system
equipped
with
combination
therapy
paracellular
transport
is
shown
enhance
efficacy
against
bacterial
improving
oral
delivery.
A
screening
platform
established
using
an
in
vitro‐induced
high
polymyxin‐resistant
strain
acquire
plumbagin,
which
enhances
polymyxin.
Functionalized
milk
extracellular
vesicles
(FMEVs)
coloaded
polymyxin
plumbagin
cleared
99%
within
4
h.
Mechanistic
studies
revealed
that
drug
damaged
membrane,
disrupted
energy
metabolism,
accelerated
death.
Finally,
FMEVs
efficiently
transported
transcellularly
through
citric
acid‐mediated
reversible
opening
tight
junctions
showed
Escherichia
coli
‐associated
peritonitis–sepsis
model
mice.
These
findings
provide
potential
therapeutic
strategy
improve
enhancing
biomimetic
platform.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 25, 2024
Abstract
Infectious
diseases
present
significant
challenges
to
global
health,
thereby
extensively
affecting
both
human
society
and
the
economy.
In
recent
years,
functional
probes
have
demonstrated
remarkable
potential
as
crucial
biomedical
media
for
research
treatment
of
infectious
diseases.
Their
applications
in
realm
include
pathogen
detection,
exploration
biological
mechanisms,
development
anti‐infective
drugs.
This
review
provides
a
concise
introduction
severity,
classification,
pathogenesis
Subsequently,
we
examined
distinctiveness
design
strategies
diagnosing
treating
diseases,
shedding
light
on
their
rationale
using
typical
examples.
We
discuss
current
status
associated
with
clinical
implementation
probes.
Furthermore,
explored
prospects
these
diagnosis
aims
offer
novel
insights
into
diagnostic
broaden
disease
treatment.
European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2024,
Volume and Issue:
199, P. 114310 - 114310
Published: May 4, 2024
Nanoparticle-based
drug
delivery
systems
hold
potential
in
chemotherapy,
but
their
limited
accumulation
tumor
tissues
hinders
effective
concentration
for
combating
growth.
Hence,
altering
the
physicochemical
properties
of
nanoparticles,
particularly
surface
charge,
can
enhance
performance.
This
study
utilized
a
computational
model
to
explore
nanoparticle
system
capable
dynamically
adjusting
its
charge.
In
model,
nanoparticles
bloodstream
were
assigned
neutral
or
positive
which,
upon
reaching
microenvironment,
switched
negative
and
releasing
chemotherapy
drugs
into
extracellular
space.
Results
revealed
that
circulating
with
despite
having
shorter
circulation
high
clearance
rate
compared
counterparts,
could
accumulate
significantly
tissue
due
transvascular
rate.
After
extravasation,
neutralized
surface-charged
tended
only
near
blood
microvessels
low
diffusion
rate,
resulting
substantial
released
drainage
back
bloodstream.
On
other
hand,
charge
tumor's
space,
reduction
nano-bio
interactions,
able
penetrate
deeper
tumor,
increasing
bioavailability
by
reducing
volume
drained
drugs.
Furthermore,
analysis
suggested
burst
release
yields
higher
than
sustained
release,
however
creation
dependent
on
tissue.
The
study's
findings
demonstrate
this
offer
valuable
insights
future
research
area.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: April 16, 2024
Abstract
The
catalytic
therapy
based
on
the
nanozymes
has
received
increasing
interest
in
cancer
treatment.
However,
capabilities
of
standalone
are
relatively
limited,
necessitating
development
a
nano‐bio
composite
system
that
integrates
both
and
natural
enzymes.
This
construction
often
inevitably
leads
to
interference
between
enzyme
nanozymes,
resulting
reduced
synergistic
performance.
Herein,
cascade
catalysis
featuring
“core@paratroopers”
structure
is
proposed,
wherein
hollow
manganese
dioxide
(HMnO
2
)
serves
as
“core”
ultra‐small
hybrid
single‐micelle
(H‐micelle)
encapsulated
with
glucose
oxidase
(GOx)
“paratroopers”
(H‐micelle‐GOx).
outer
SiO
layer
H‐micelle
can
effectively
protect
GOx.
Under
hypoxic
conditions,
HMnO
reacts
endogenous
H
O
produce
,
thereby
enhancing
efficiency
GOx
for
starvation
therapy.
Simultaneously,
generated
boosts
accelerating
local
generation
alleviating
tumor
hypoxia.
Additionally,
this
exhibits
rapid
degradation
microenvironment
characterized
by
high
glutathione
(GSH)
expression,
facilitating
release
deep
penetration
H‐micelle‐GOx
within
solid
tumor.
Nano Convergence,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: April 18, 2024
Abstract
Nanomedicine
has
been
extensively
explored
for
therapeutic
and
diagnostic
applications
in
recent
years,
owing
to
its
numerous
advantages
such
as
controlled
release,
targeted
delivery,
efficient
protection
of
encapsulated
agents.
Integration
microneedle
technologies
with
nanomedicine
the
potential
address
current
limitations
drug
delivery
including
relatively
low
efficacy
poor
patient
compliance
enable
theragnostic
uses.
In
this
Review,
we
first
summarize
representative
types
describe
their
broad
applications.
We
then
outline
challenges
faced
by
nanomedicine,
a
focus
on
issues
related
physical
barriers,
biological
compliance.
Next,
provide
an
overview
systems,
definition,
manufacturing
strategies,
release
mechanisms,
challenges.
also
discuss
use
microneedle-mediated
systems
Finally,
perspective
status
future
prospects
biomedical
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1043 - 1043
Published: Aug. 6, 2024
Chitosan
nanoparticles
(CSNPs)
are
promising
vehicles
for
targeted
and
controlled
drug
release.
Recognized
their
biodegradability,
biocompatibility,
low
toxicity,
ease
of
production,
CSNPs
represent
an
effective
approach
to
delivery.
Encapsulating
drugs
within
(NPs)
provides
numerous
benefits
compared
free
drugs,
such
as
increased
bioavailability,
minimized
toxic
side
effects,
improved
delivery,
the
incorporation
additional
features
like
release,
imaging
agents,
combination
therapies
with
multiple
drugs.
Keys
parameters
in
nanomedicines
loading
content
efficiency.
Most
current
NP
systems
struggle
loading,
presenting
a
significant
challenge
field.
This
review
summarizes
recent
research
on
developing
high
capacity,
focusing
various
synthesis
strategies.
It
examines
CSNP
using
different
materials
providing
details
methods,
loadings,
encapsulation
efficiencies,
release
profiles,
stability,
applications
Additionally,
discusses
factors
affecting
valuable
guidelines
future
CSNPs’
development.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
The
surface
charge
of
nanoparticles
(NPs)
is
one
the
major
physicochemical
factors
for
their
interactions
in
biological
systems.
To
improve
behavior
NPs
cellular
environment,
there
are
numerous
efforts
to
evaluate
effect
on
uptake
NPs.
In
this
study,
we
synthesized
Pluronic
block
copolymer
F127-based
by
modifying
both
ends
with
phosphate
(PP)
impart
a
negative
and
trimethylammonium
bromide
(AB)
confer
positive
charge.
By
varying
ratios
PP-F127
AB-F127,
produced
range
densities
through
self-assembly
method
aqueous
solution,
resulting
semi-interpenetrating
network
structure
core.
were
characterized,
was
evaluated
HeLa
cells.
Our
findings
indicate
that
positively
charged
AB-NPs
internalized
more
efficiently
into
cells
than
negatively
PP-NPs.
These
results
highlight
importance
NP
determining
uptake,
providing
valuable
insights
designing
NP-based
drug
delivery
