Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
Abstract
The
increasing
occurrence
of
infections
caused
by
multidrug‐resistant
(MDR)
bacteria
drives
the
need
for
new
antibacterial
drugs.
Due
to
current
lack
antibiotic
discovery
and
development,
strategies
fight
MDR
are
urgently
needed.
Efforts
develop
adjuvants
increase
effectiveness
existing
antibiotics
design
delivery
systems
essential
address
this
issue.
Here,
a
bioinspired
system
equipped
with
combination
therapy
paracellular
transport
is
shown
enhance
efficacy
against
bacterial
improving
oral
delivery.
A
screening
platform
established
using
an
in
vitro‐induced
high
polymyxin‐resistant
strain
acquire
plumbagin,
which
enhances
polymyxin.
Functionalized
milk
extracellular
vesicles
(FMEVs)
coloaded
polymyxin
plumbagin
cleared
99%
within
4
h.
Mechanistic
studies
revealed
that
drug
damaged
membrane,
disrupted
energy
metabolism,
accelerated
death.
Finally,
FMEVs
efficiently
transported
transcellularly
through
citric
acid‐mediated
reversible
opening
tight
junctions
showed
Escherichia
coli
‐associated
peritonitis–sepsis
model
mice.
These
findings
provide
potential
therapeutic
strategy
improve
enhancing
biomimetic
platform.
Particle and Fibre Toxicology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Dec. 4, 2024
Inorganic
ultraviolet
filters
such
as
titanium
dioxide
nanoparticles
are
frequently
used
in
sunscreens.
Numerous
toxicological
studies
vitro
and
vivo
have
been
conducted
using
pristine
standard
reference
nanomaterials
of
these
inorganic
filters.
While
convenient,
this
approach
is
not
realistic
because
the
complex
environment
sunscreen
formulations
could
change
physicochemical
properties
lead
to
vastly
different
outcomes.
Therefore,
study
focused
on
characterizing
extracted
from
commercial
evaluating
associated
impacts
upon
exposure
human
keratinocytes
skin
explants.
Titanium
were
sunscreens
thoroughly
characterized.
The
identity
molecular
corona
was
also
evaluated.
Cell
metabolic
proliferation
profiles,
mitochondrial
superoxide
activity,
reactive
oxygen
species
levels,
genotoxicity
induced
through
studied
a
keratinocyte
cell
line.
response
significantly
after
treatment
with
compared
corresponding
sunscreen-extracted
nanoparticles.
Pristine
spherical
resulted
more
pronounced
toxicity
2D
cultured
but
did
impact
wound-edge
migration
3D
ex
explant
models.
Additionally,
rod-shaped
had
greater
toxic
retarded
model
Nevertheless,
heightened
responses
any
increase
phosphorylated
γH2AX
(which
indicative
DNA
damage)
both
vivo.
This
shows
feasibility
extracting
personal
care
products
obtain
relevant
forms
real-life
scenarios.
Overall,
found
be
less
equivalents
significantly.
Skin
cultures
provide
alternative
monolayer
cultures,
although
differential
outcomes
between
models
need
in-depth
evaluation.
Materials Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Deformed
organosilica
nanoprobes
(CDPF)
exhibit
enhanced
accumulation
within
larger
tumors,
highlighting
the
pivotal
role
of
tumor
microenvironment
in
optimization
nanoparticle-based
therapeutic
strategies.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 6451 - 6466
Published: Sept. 24, 2024
Targeting
current
therapies
to
treat
or
prevent
the
loss
of
pancreatic
islet
β-cells
in
Type
1
Diabetes
(T1D)
may
provide
improved
efficacy
and
reduce
off-target
effects.
Current
efforts
target
β-cell
are
limited
by
a
lack
β-cell-specific
targets
inability
test
multiple
targeting
moieties
with
same
delivery
vehicle.
Here,
we
fabricate
tailorable
polycaprolactone
nanocapsule
(NC)
which
different
peptides
can
be
interchangeably
attached
for
delivery.
Incorporation
cationic
surfactant
NC
shell
allows
attachment
Exendin-4
an
antibody
ectonucleoside
triphosphate
diphosphohydrolase
3
(ENTPD3)
targeting.
The
average
size
ranges
from
250
300
nm
polydispersity
index
under
0.2.
NCs
nontoxic,
stable
media
culture,
lyophilized
reconstituted.
coated
peptide
were
taken
up
human
cadaveric
stem
cell-derived
β-like
cells
(sBC)
vitro
high
level
specificity.
Furthermore,
successfully
delivered
both
hydrophobic
hydrophilic
cargo
β-cells.
Additionally,
Exendin-4-coated
targeted
mouse
vivo.
Overall,
our
have
potential
improve
cell-targeted
drug
utilized
as
screening
platform
cell-targeting
peptides.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 18, 2024
Targeting
of
current
therapies
to
treat
or
prevent
loss
pancreatic
islet
β-cells
in
Type
1
Diabetes
(T1D)
may
provide
improved
efficacy
and
reduce
off
target
effects.
Current
efforts
the
β-cell
are
limited
by
a
lack
specific
targets
inability
test
multiple
targeting
moieties
with
same
delivery
vehicle.
Here
we
fabricate
novel
tailorable
polycaprolactone
nanocapsule
(NC)
where
different
peptides
can
be
interchangeably
attached
for
delivery.
Incorporation
cationic
surfactant
NC
shell
allows
attachment
Exendin-4
an
antibody
ectonucleoside
triphosphate
diphosphohydrolase
3
(ENTPD3)
targeting.
The
average
size
ranges
from
250-300nm
polydispersity
index
under
0.2.
NCs
non-toxic,
stable
media
culture,
lyophilized
reconstituted.
coated
peptide
were
taken
up
human
cadaveric
stem
cell-derived
β-like
cells
(sBC)
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
Abstract
The
increasing
occurrence
of
infections
caused
by
multidrug‐resistant
(MDR)
bacteria
drives
the
need
for
new
antibacterial
drugs.
Due
to
current
lack
antibiotic
discovery
and
development,
strategies
fight
MDR
are
urgently
needed.
Efforts
develop
adjuvants
increase
effectiveness
existing
antibiotics
design
delivery
systems
essential
address
this
issue.
Here,
a
bioinspired
system
equipped
with
combination
therapy
paracellular
transport
is
shown
enhance
efficacy
against
bacterial
improving
oral
delivery.
A
screening
platform
established
using
an
in
vitro‐induced
high
polymyxin‐resistant
strain
acquire
plumbagin,
which
enhances
polymyxin.
Functionalized
milk
extracellular
vesicles
(FMEVs)
coloaded
polymyxin
plumbagin
cleared
99%
within
4
h.
Mechanistic
studies
revealed
that
drug
damaged
membrane,
disrupted
energy
metabolism,
accelerated
death.
Finally,
FMEVs
efficiently
transported
transcellularly
through
citric
acid‐mediated
reversible
opening
tight
junctions
showed
Escherichia
coli
‐associated
peritonitis–sepsis
model
mice.
These
findings
provide
potential
therapeutic
strategy
improve
enhancing
biomimetic
platform.
