Nature Catalysis, Journal Year: 2024, Volume and Issue: 7(12), P. 1261 - 1263
Published: Dec. 20, 2024
Language: Английский
Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 18, 2025
Comprehensive Summary Artificial cell wall (ACW) referring to active functional cellular nano‐coatings is capable of providing more cell‐shell synergic and cooperative properties than conventional single nanoencapsulation (SCNE). With the development SCNE, issues cytocompatibility, degradability, etc ., have already been improved successively. However, further emphasis on cooperativity between itself its shell still missing paying attention functions hybrids. Recent research proved that construction nano‐coating cells not only needs satisfy functionalization cells, but also necessary empower interact with other environments. This indicates SCNEs are tending be “active” participate in metabolic process gradually develop stage ACWs. review provided a reasonable description artificial wall, realization this concept requires cooperativity, self‐adaption fluxionality. Then, methodologies constructing ACWs were discussed. Finally, applications summarized accompanied by potential outlook given fields. Key Scientists Within recent ten years, fabricating biocompatible surface for cyto‐protection rapidly developed. For example, Rawil F. Fakhrullin Yuri M. Lvov developed ‘layer‐by‐layer’ strategy construct ‘face‐lifting’ micro‐organisms. Afterwards, Choi introduced ‘artificial spore’ which thin tough encapsulations. At same time, Tsukruk hydrogel‐based terms 2013. In 2016, Tang reported biomimetic mineralization can used improve modify metabolism processes cells. More advanced, Qu Hawker separately way introduce manganese dioxide nanozymes in‐situ ‐grafting polymers realize responsive effects towards regulation 2017. 2018, Huang showed generate type heritable based situ self‐assembly coacervate micro‐droplets around yeast 2019, Jeffrey nanoparticles adopted exoskeletons outside endow new forming ‘supracells’. put forward concepts ‘active shell’ ‘dynamic indicated nanoencapsulations was beginning transition control fate degradable walls 2020 an intracellular method regulate algae promote hydrogen production. Based his previous research, focused introducing fabrication wall’.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
The self-assembly of molecules into highly ordered architectures is a ubiquitous and natural process, wherein spontaneously organize large structures to perform diverse functions. Drawing inspiration from the formation nanostructures, cell-mediated has been developed create functional assemblies both inside outside living cells. These techniques have employed regulate cellular world by leveraging dynamic intracellular extracellular microenvironment. This review highlights recent advances future trends in self-assembly, ranging their cytocompatible monomer designs, synthetic strategies, morphological control applications. assembly behaviors are also discussed based on dimensionality self-assembled morphologies zero three dimensions. Finally, this explores its promising potential for biomedical applications, clarifying relationship between initial regulation therapeutic effects subsequent artificial assemblies. Through rationally designing molecular precisely controlling morphologies, cell mediated would provide an innovative platform executing biological
Language: Английский
Citations
1
Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Cell-interface engineering is a way to functionalize cells through direct or indirect self-assembly of functional materials around the cells, showing an enhancement cell functions. Among used in cell-interface engineering, natural biomolecules play pivotal roles study biological interfaces, given that they have good advantages such as biocompatibility and rich groups. In this review, we summarize overview development studies been cell-biointerface then review five main types constructing biointerfaces, namely DNA polymers, amino acids, polyphenols, proteins polysaccharides, show their applications green energy, biocatalysis, therapy environmental protection remediation. Lastly, current prospects challenges area are presented with potential solutions solve these problems, which turn benefits design next-generation engineering.
Language: Английский
Citations
1
Published: March 7, 2025
Language: Английский
Citations
0
Biotechnology Advances, Journal Year: 2025, Volume and Issue: unknown, P. 108566 - 108566
Published: March 1, 2025
Language: Английский
Citations
0
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: May 22, 2025
Nature has evolved adaptive strategies to protect living cells and enhance their resilience against hostile environments, exemplified by bacterial fungal spores. Inspired cryptobiosis in nature, chemists have designed synthesized artificial "cell-in-shell" structures, endowed with the protective functional capabilities of nanoshells. The cell-in-shells hold potential overcome inherent limitations biologically naı̈ve cells, enabling acquisition exogenous phenotypic traits through chemical process known as single-cell nanoencapsulation (SCNE). This review highlights recent advancements development spores, sections organized based on categorization material types utilized SCNE, specifically organic, hybrid, inorganic types. Particular emphasis is placed cytoprotective multifunctional roles nanoshells, demonstrating applications SCNEd across diverse fields, including synthetic biology, biochemistry, materials science, biomedical engineering. Furthermore, perspectives outlined this propose future research directions goal achieving fine-tuned precision modulation at both intracellular pericellular levels, paving way for design construction customized spores tailored meet specific needs.
Language: Английский
Citations
0
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Abstract Within living organisms, numerous nanomachines are constantly involved in complex polymerization processes, generating a diverse array of biomacromolecules for maintaining biological activities. Transporting artificial polymerizations from lab settings into contexts has expanded opportunities understanding and managing events, creating novel cellular compartments, introducing new functionalities. This review summarizes the recent advancements polymerizations, including those responding to external stimuli, internal environmental factors, that polymerize spontaneously. More importantly, cutting‐edge biomedical application scenarios polymerization, notably safeguarding cells, modulating improving diagnostic performance, facilitating therapeutic efficacy highlighted. Finally, this outlines key challenges technological obstacles remain as well offers insights potential directions advancing their practical applications clinical trials.
Language: Английский
Citations
1
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(43)
Published: Aug. 1, 2024
Abstract Within living organisms, numerous nanomachines are constantly involved in complex polymerization processes, generating a diverse array of biomacromolecules for maintaining biological activities. Transporting artificial polymerizations from lab settings into contexts has expanded opportunities understanding and managing events, creating novel cellular compartments, introducing new functionalities. This review summarizes the recent advancements polymerizations, including those responding to external stimuli, internal environmental factors, that polymerize spontaneously. More importantly, cutting‐edge biomedical application scenarios polymerization, notably safeguarding cells, modulating improving diagnostic performance, facilitating therapeutic efficacy highlighted. Finally, this outlines key challenges technological obstacles remain as well offers insights potential directions advancing their practical applications clinical trials.
Language: Английский
Citations
1
Advanced Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 18, 2024
This study investigates the formation and properties of vesicles produced via biocatalytic Polymerization-Induced Self-Assembly (bioPISA) as artificial cells. Methods for achieving size uniformity, including gentle centrifugation sucrose gradient centrifugation, are explored, effects stirring speed on vesicle morphology is investigated. The internal structure vesicles, characterized by a polymer-rich matrix, analyzed using fluorescence correlation spectroscopy (FCS). Additionally, feasibility loading macromolecules into pre-formed demonstrated electroporation, fluorescent protein well enzymes cascade reaction were sucesfully incorporated fully assembled polymersomes. These findings provide foundation developing enzyme-synthesized polymeric with controlled morphologies various applications, e.g., in synthetic biology.
Language: Английский
Citations
1
Langmuir, Journal Year: 2024, Volume and Issue: 40(43), P. 23033 - 23040
Published: Oct. 17, 2024
Inspired by iron gall ink (IGI), the Fe
Language: Английский
Citations
0