Controlled Photooxidation via Singlet Oxygen Generation by Triplet Harvesting in a Heavy Atom Free Pure Organic Dithienylethene‐Naphthalene Diimide DOI

Sayan Kumar Bag,

Bijan Mondal,

Manisha Karmakar

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(61)

Published: Aug. 14, 2024

Abstract Noninvasive control over the reversible generation of singlet oxygen ( 1 O 2 ) has found enormous practical implications in field biomedical science. However, metal‐free pure organic emitters, connected with a photoswitch, capable generating “on‐demand” via triplet harvesting remain exceedingly rare; therefore, utilization these materials for production remains at its infancy. Herein, an ambient mediated emission quinoline‐dithienylethene (DTE)‐core‐substituted naphthalene diimide (cNDI) derivative is unveiled delayed fluorescence. The quinoline‐DTE‐cNDI triad displayed enhanced photoswitching efficiency double FRET mechanism. It was to have direct controlled photosensitized transformations efficient (yield Φ Δ ~0.55 DCM and 0.73 methanol). designed molecule exhibits long‐lived (τ∼1.1 μs) very small singlet‐triplet splitting (ΔE ST 0.13 eV empowering it display Comprehensive steady state time‐resolved spectroscopy (TRES) analyses along DFT calculations offer detailed understandings into excited‐state manifolds compound energy transfer (ET) pathways involved generation.

Language: Английский

Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4
Au-H2Ti3O7 nanotubes for non-invasive anticancer treatment by simultaneous photothermal and photodynamic therapy DOI Creative Commons

Maher I. Al-Shemri,

Maryam Aliannezhadi, Rana A. Ghaleb

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 29, 2024

Treating lung and prostate cancer cells is a major health problem that may be solved through the interactions of laser beams with nanoparticles. In paper, Au-H2Ti3O7 nanotubes (NTs) are proposed as treatment agent different nanostructure considered to solve mentioned problem. Also, NTs employed treat cancers in dark conditions. The results motivating because NPs do not affect healthy cells, while they strongly viability percentage LNCap reaches 16% for incubation times 48 h. Furthermore, treating using irradiated by NIR beam at 808 nm has no cytotoxicity, cytotoxicity 92% obtained an irradiation 532 nm. applying 635 leads ∼53% (A549 cells). total, have selective effect on greatly reduce given conditions, leading introduction them promising non-invasive moderate candidate therapy.

Language: Английский

Citations

5
Nanoarchitectonics of fluorescent gold nanoclusters: A platform for image guided photodynamic therapy of hypoxic tumor DOI

Resmi A.N.,

S. Sivaselvam,

Rekha C.R.

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102273 - 102273

Published: June 8, 2024

Language: Английский

Citations

4
Three‐in‐One: Molecular Engineering of D–A–π–A Featured Type I and Type II Near‐Infrared AIE Photosensitizers for Efficient Photodynamic Cancer Therapy and Bacteria Killing DOI
Yun‐Yun Quan, Tingting Pan, Zhongda Zhang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: Aug. 1, 2024

Abstract Bacterial infections are closely correlated with the genesis and progression of cancer, elimination cancer‐related bacteria may improve efficacy cancer treatment. However, combinatorial therapy that utilizes two or more chemodrugs will increase potential adverse effects. Image‐guided photodynamic is a highly precise to treat tumor microbial infections. Herein, four donor–acceptor–π‐bridge–acceptor (D–A–π–A) featured near‐infrared (NIR) aggregation‐induced emission luminogens (AIEgens) ( TQTPy , TPQTPy TQTC TPQTC ) type I II reaction oxygen species (ROS) generation capabilities synthesized. Notably, shows mitochondria targeted capacity, best ROS production efficiency, long‐term retention importantly, three‐in‐one fluorescence imaging guided against both Both in vitro vivo results validate performs well practical biomedical application terms NIR‐fluorescence imaging‐guided diagnosis Moreover, amphiphilic positively charged able specific ultrafast discrimination Gram‐positive (G+) Staphylococcus aureus from Gram‐negative (G−) Escherichia coli normal cells. This investigation provides an instructive way for construction treatment image‐guided elimination.

Language: Английский

Citations

4
Solar‐to‐NIR Light Activable PHBV/ICG Nanofiber‐Based Face Masks with On‐Demand Combined Photothermal and Photodynamic Antibacterial Properties DOI
Mohammad Ali Haghighat Bayan, Chiara Rinoldi, Alicja Kosik‐Kozioł

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Hierarchical nanostructures fabricate by electrospinning in combination with light‐responsive agents offer promising scenarios for developing novel activable antibacterial interfaces. This study introduces an innovative face mask developed from poly(3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHBV) nanofibers integrated indocyanine green (ICG), targeting the urgent need effective antimicrobial protection community health workers. The research focuses on fabricating and characterizing this nanofibrous material, evaluating mask's mechanical chemical properties, investigating its particle filtration, assessing efficacy under photothermal conditions reactive oxygen species (ROS) generation. PHBV/ICG are produced using process, construct's morphology, structure, response investigated. of is tested, substantial bacterial inactivation both near‐infrared (NIR) solar irradiation demonstrated due to nanofibers. material's further analyzed cyclic simulate real‐world conditions, confirming durability consistency. highlights synergistic impact PHBV ICG enhancing activity, presenting a biocompatible environmentally friendly solution. These findings path masks that contribute significantly field materials solve critical public challenges.

Language: Английский

Citations

4
Photocatalytic detoxification of a sulfur mustard simulant by donor-enhanced porphyrin-based Covalent-Organic Frameworks DOI

Yana Chen,

Zewen Shen,

Yuping Hu

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Porphyrin-based COF-OMe with a strong electron-donating group exhibited the highest photocatalytic activity among three COFs for detoxification of CEES in methanol solvent.

Language: Английский

Citations

0
Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates DOI Open Access

Hongjing Sun,

Michele M. Kim, Yi Hong Ong

et al.

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Photodynamic therapy (PDT) has shown promise as an adjuvant treatment for malignant pleural mesothelioma when combined with surgical resection. Accurate light dosimetry is critical efficacy. This study presents improved method analyzing fluence distribution in PDT using a standardized anatomical coordinate system and advanced computational modeling. We utilized infrared navigation delivery wand to track real‐time. The human chest cavity geometry was reconstructed the pleura mapped system, allowing direct comparisons across patients. Light calculated both primary scattered components, novel dual correction applied match measured values at detector locations. approach allowed statistical analysis of regions cohort 11 Results showed acceptable uniformity standard deviation 6.6% from prescribed dose comprehensive provides insights optimizing protocols lays groundwork future studies on singlet oxygen generation its correlation outcomes PDT.

Language: Английский

Citations

0
An efficient circularly polarized luminescence probe base on anthryl-modified Eu(III)-helicates for the detection and imaging singlet oxygen in living cells DOI
Xiumei Zhang, Xinglu Wang,

Wenru Huang

et al.

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 269, P. 112881 - 112881

Published: March 4, 2025

Language: Английский

Citations

0
Beyond the Swipe: A Review of Photocatalytic Antimicrobial Biocompatible Touchscreen Technology DOI
Nelson Oshogwue Etafo, Abayomi Bamisaye, Muyideen Olaitan Bamidele

et al.

Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102697 - 102697

Published: March 30, 2025

Language: Английский

Citations

0
Enzyme-triggered aggregation of upconversion nanoparticles for targeted photodynamic therapy DOI
Bo Ling, Yaguang Wang,

Huaze Dong

et al.

PubMed, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

A core-shell-shell nanoplatform responsive to alkaline phosphatase (ALP) was developed for efficient tumor targeting and near-infrared (NIR)-activated photodynamic therapy (PDT). Specifically, UCNP@SiO2-Bodipy@FFYp synthesized by encapsulating upconversion nanoparticles (UCNPs) within a silica shell, embedding bodipy derivatives as photosensitizers, covalently attaching phosphorylated peptide (FFYp). Förster resonance energy transfer (FRET) from the UCNP emission at 550 nm facilitated reactive oxygen species (ROS) generation upon NIR excitation. In microenvironment, ALP-triggered dephosphorylation converted into more hydrophobic UCNP@SiO2-Bodipy@FFY, thereby promoting cell uptake tumor-specific accumulation. By leveraging this ALP-responsive strategy alongside deep-tissue penetration of light, significant growth inhibition achieved both in vitro vivo. Notably, after 15 days treatment Balb/c mice bearing HeLa tumors, volume reduced over 95%. Taken together, these results highlight promise tumor-responsive highly effective, targeted PDT cancer therapy.

Language: Английский

Citations

0