The efficient synthesis of three-membered rings via photo- and electrochemical strategies DOI Creative Commons
Xinyu Han, Na Zhang, Qiannan Li

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(34), P. 13576 - 13604

Published: Jan. 1, 2024

Three-membered rings, such as epoxides, aziridines, oxaziridines, cyclopropenes, vinyloxaziridines, and azirines, are recognized crucial pharmacophores building blocks in organic chemistry drug discovery. Despite the significant advances synthesis of these rings through photo/electrochemical methods over past decade, there has currently been no focused discussion updated overviews on this topic. Therefore, we presented review article efficient three-membered using photo- electrochemical strategies, covering literature since 2015. In study, a conceptual overview detailed discussions were provided to illustrate advancement field. Moreover, brief outlines current challenges opportunities synthesizing strategies.

Language: Английский

A concise total synthesis of monoterpenoid indole alkaloid (-)-voacafricine A DOI
Xuan Pan, Tao Sheng, Zhanzhu Liu

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110913 - 110913

Published: Feb. 1, 2025

Language: Английский

Citations

0
1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells DOI Open Access

Meng-Xue Hu,

Jiaqi Li, Hongwei Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117907 - 117907

Published: Feb. 19, 2025

Language: Английский

Citations

0
Photoinduced [3+2] Cycloaddition of Alkyl–Acceptor Diazoalkanes: Diversity-Oriented Synthesis of Pyrazolines Containing a Quaternary Center DOI

Fengya He,

Ziyi Sun,

Yiwei Xu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(19), P. 4031 - 4036

Published: Jan. 26, 2024

We present a new [3+2] cycloaddition reaction between alkyl-acceptor diazoalkanes under visible light irradiation. By employing easily accessible alkyl-acceptor-type or their precursor hydrazones as both 1,3-dipoles and dipolarophiles, diverse range of pyrazoline derivatives featuring quaternary center have been efficiently synthesized in predictable manner, with excellent functional group tolerance good yields. Furthermore, scale-up experiments downstream transformations the product were also detailed.

Language: Английский

Citations

2
The efficient synthesis of three-membered rings via photo- and electrochemical strategies DOI Creative Commons
Xinyu Han, Na Zhang, Qiannan Li

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(34), P. 13576 - 13604

Published: Jan. 1, 2024

Three-membered rings, such as epoxides, aziridines, oxaziridines, cyclopropenes, vinyloxaziridines, and azirines, are recognized crucial pharmacophores building blocks in organic chemistry drug discovery. Despite the significant advances synthesis of these rings through photo/electrochemical methods over past decade, there has currently been no focused discussion updated overviews on this topic. Therefore, we presented review article efficient three-membered using photo- electrochemical strategies, covering literature since 2015. In study, a conceptual overview detailed discussions were provided to illustrate advancement field. Moreover, brief outlines current challenges opportunities synthesizing strategies.

Language: Английский

Citations

2