Silver‐catalyzed Cascade Bis‐heteroannulation Reaction of Enynones and o‐Hydroxyphenyl Enaminones: Access to Highly Functionalized 3‐Furylmethyl Chromones

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(10), P. 2363 - 2369

Published: March 16, 2024

Abstract A synthetic protocol was developed to synthesize highly functionalized 3‐furylmethyl chromones from enynones and o ‐hydroxyphenyl enaminones via silver‐catalyzed cascade bis‐heteroannulation reaction. This strategy features broad substrate scope good functional group tolerance. Furthermore, the chromone skeleton shows potential application value through further gram‐scale synthesis derivatization.

Language: Английский

---

Recent advances in hydrofunctionalisation of cyclopropenes via carbon–heteroatom bond formation

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights recent advances in the hydrofunctionalisation of cyclopropenes through formation carbon–heteroatom bonds for synthesis polysubstituted cyclopropanes.

Language: Английский

---

Oxidative Free-Radical C(sp²)–H Bond Chlorination of Enaminones with LiCl: Access to Highly Functionalized α-Chlorinated Enaminones

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(12), P. 8521 - 8530

Published: June 3, 2024

An oxidative free-radical C(sp2)–H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and K2S2O8 an oxidant. This transformation provides new straightforward synthetic methodology to afford highly functionalized α-chlorinated with Z-configuration in good excellent yields.

Language: Английский

---

Copper-Catalyzed Oxidative [3 + 2] Cycloaddition of Enamines and Pyridotriazoles toward Indolizines

Organic Letters, Journal Year: 2024, Volume and Issue: 26(6), P. 1249 - 1254

Published: Feb. 2, 2024

An efficient copper catalytic system has been established for the synthesis of highly functional indolizines through oxidative [3 + 2] cycloaddition enamines and pyridotriazoles. This modular platform is compatible with a broad range groups, including natural complex skeletons, allowing late-stage modifications. It features step-economical, regioselective, easy-handling procedure applied in constructing small molecules potent activity toward inhibiting VEGF–NRP1 interaction one-pot reaction pyridotriazoles, amines, aldehydes.

Language: Английский

---

Pd(II) Auxiliaries Assembling and Diverse Transformations via Inert C(sp3)–H Bond Activation

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The construction of new C–C bonds via inert C(sp 3 )–H bond activation has garnered significant achievements in recent decades, particularly with palladacycles serving as pivotal intermediates.

Language: Английский

---

Rh-Catalyzed Enantioselective Synthesis of Acyclic Quaternary Carbons via Carbene Insertion

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 5273 - 5282

Published: March 13, 2025

Language: Английский

---

Cascade Annulation for Synthesizing Chromenopyrrolones from o-Hydroxyphenyl Enaminones and 2-Halo-N-alkyloxyacetamides

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

A cascade cyclization reaction comprising two halogenation reactions and a Michael addition was developed for the synthesis of chromeno[2,3-

Language: Английский

---

NBS-Mediated C(sp2)-H Bond Chlorination of Enaminones: Using DCE as Chlorine Source

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12073 - 12073

Published: Nov. 10, 2024

Commercial DCE is excavated as both a "Cl" source and solvent for the vinyl C(sp

Language: Английский

---