The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(18), P. 13678 - 13690
Published: Sept. 6, 2024
Herein,
a
visible-light-promoted
radical
cascade
cyclization
of
heterocyclic
ketene
aminals
(HKAs)
and
thiocyanates
was
developed
to
access
functionalized
fused
2-iminothiazolines.
This
novel
reaction
can
be
realized
under
only
visible-light
irradiation
without
the
help
external
photocatalysts,
oxidants,
additives.
These
multicomponent
reactions
demonstrate
excellent
selectivity
for
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(39), P. 7214 - 7219
Published: Sept. 26, 2023
A
novel
Rh(III)-catalyzed
cascade
alkenyl
C-H
activation/[3
+
2]
annulation/pinacol
rearrangement
reaction
of
enaminones
with
iodonium
ylides
has
been
developed.
This
methodology
provides
a
new
and
straightforward
synthetic
strategy
to
afford
highly
functionalized
2-spirocyclo-pyrrol-3-ones
in
satisfactory
yield
from
readily
available
starting
materials
under
mild
conditions.
Moreover,
gram-scale
reactions
further
derivatization
experiments
are
implemented
demonstrate
the
potential
utility
this
developed
approach.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 11060 - 11066
Published: July 24, 2024
Reported
herein
is
a
new
photocatalytic
annulation
for
the
synthesis
of
2,3,4,6-tetrasubstituted
pyridines
with
enaminones
and
N,N,N′,N′-tetramethyl
ethylenediamine
(TMEDA).
The
reactions
take
place
without
requiring
transition
metal
reagent
provide
products
broad
scope.
methyl
in
TMEDA
acts
as
carbon
source
pyridine
ring
construction,
BrCF2CO2Et
plays
role
terminal
oxidant
free
radical
quenching.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8521 - 8530
Published: June 3, 2024
An
oxidative
free-radical
C(sp2)–H
bond
chlorination
strategy
of
enaminones
has
been
developed
by
using
LiCl
as
a
chlorinating
reagent
and
K2S2O8
an
oxidant.
This
transformation
provides
new
straightforward
synthetic
methodology
to
afford
highly
functionalized
α-chlorinated
with
Z-configuration
in
good
excellent
yields.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(9), P. 2607 - 2612
Published: Jan. 1, 2024
A
metal-free,
scalable,
and
cascade
protocol
for
assembling
diverse
polysubstituted
pyridines
from
tertiary
enaminones
α,β-unsaturated
sulfonylketimines
by
cleaving
C–N/N–S
bonds
is
reported.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(19), P. 4139 - 4144
Published: July 2, 2024
Abstract
A
copper‐catalyzed
annulation
of
enaminones
with
maleimides
was
developed
to
synthesize
various
pyrrolo[3,4‐e]isoindoles.
In
this
strategy,
2‐aminopyridine
served
as
a
traceless
directing
group,
and
target
products
were
obtained
in
54–72%
yields.
Moreover,
plausible
mechanism
for
reaction
proposed
based
on
several
control
experiments,
deuterium
exchange
previous
reports.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
We
developed
a
cascade
C–H
activation/[3
+
2]
annulation
for
enaminones
and
vinylene
carbonate,
employing
the
catalyst
[Cp*RhCl
2
]
oxidants.
This
reaction
allows
efficient
synthesis
of
3-carbonylpyrroles.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 16, 2024
The
sequential
synthesis
of
N-heterocycles
from
saturated
ketones
poses
significant
challenges
and
has
rarely
been
reported.
Herein,
an
efficient
alkenylated
dihydroquinolinones
7
hexahydroacridinones
8
is
achieved
1
or
2
via
dehydrogenation,
cyclization,
oxidation,
α-alkenylation
in
choline
chloride-based
deep
eutectic
solvent
(DES)
medium.
This
strategy
provides
excellent
yield
low-cost,
readily
available
starting
materials
under
environmentally
benign
conditions.
Furthermore,
the
synthesized
compounds
(4,
5,
7,
8)
were
investigated
for
their
photophysical
properties
through
absorption
emission
spectral
studies.
