
Coordination chemistry research., Journal Year: 2024, Volume and Issue: unknown, P. 100003 - 100003
Published: Dec. 1, 2024
Language: Английский
Coordination chemistry research., Journal Year: 2024, Volume and Issue: unknown, P. 100003 - 100003
Published: Dec. 1, 2024
Language: Английский
ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(4), P. 2746 - 2757
Published: Feb. 7, 2024
Remote stereocontrol in transition-metal catalysis is a challenging but interesting research topic. In this work, we achieved copper-catalyzed asymmetric yne-allylic substitution using electron-rich arenes and acyclic carbonates through remote enantioselectivity control. The reaction delivers variety of enantioenriched products that contain diverse set valuable moieties, such as conjugated enynes, indoles, indolizines, allenes, dihydrofurans, which are widely used organic synthesis act key units bioactive molecules natural products. synthetic value protocol has been demonstrated series further transformations, mechanistic studies have conducted to gain more insight into the reaction.
Language: Английский
Citations
23Chemical Communications, Journal Year: 2024, Volume and Issue: 60(31), P. 4210 - 4213
Published: Jan. 1, 2024
The unprecedented copper-catalyzed asymmetric alkynylallylic monofluoroalkylation reaction is described
Language: Английский
Citations
13ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(12), P. 9254 - 9264
Published: June 3, 2024
Catalytic asymmetric dearomatization reactions of α-unsubstituted β-naphthols are very challenging due to the high energy barrier resulting from loss aromaticity. Herein, we describe an example enantioselective catalytic dearomative spiroannulation with yne-allylic esters. The success this reaction relied on copper-catalyzed remote strategy using esters as bis-electrophilic reagents. This transformation features mild conditions, broad functional group tolerance, and extensive substrate scope, thereby facilitating efficient construction array enantioenriched naphthalene-2-one spiroindolenine derivatives. Experimental studies density theory calculations establish pathway origin stereoselectivity.
Language: Английский
Citations
12Tetrahedron Chem, Journal Year: 2024, Volume and Issue: 11, P. 100082 - 100082
Published: July 3, 2024
Language: Английский
Citations
11ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 2415 - 2423
Published: Jan. 27, 2025
Language: Английский
Citations
1Organic Letters, Journal Year: 2024, Volume and Issue: 26(27), P. 5758 - 5763
Published: July 1, 2024
Anthrones are key structural motifs in many natural products and pharmaceutical chemicals. However, due to its unique tricyclic aromatic structure, the synthetic space for development of chiral anthrone derivatives is largely limited. By utilizing potential copper-catalyzed remote asymmetric yne-allylic substitution reaction, we describe first example highly regio- enantioselective on various esters with anthrones under a mild reaction condition, which afforded range enantioenriched 1,3-enynes exhibiting broad functional group tolerance across 51 examples.
Language: Английский
Citations
7Organic Letters, Journal Year: 2024, Volume and Issue: 26(30), P. 6407 - 6412
Published: July 19, 2024
Chiral coumarins and their derivatives are ubiquitous structural motifs found in an array of biologically therapeutically active natural products drugs. Herein, a highly enantioselective dual remote copper-catalyzed vinylogous alkynylallylic substitution yne-allylic esters with has been developed. The practicality this method is exemplified by the use readily available starting materials; mild reaction conditions; excellent regio-, enantio-, stereoselectivities; very broad substrate scope (67 examples), while scalability further applications illustrated gram-scale series derivations products.
Language: Английский
Citations
7ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(15), P. 11646 - 11656
Published: July 22, 2024
Language: Английский
Citations
7Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
1Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110114 - 110114
Published: June 1, 2024
Language: Английский
Citations
6