Coordination chemistry research., Год журнала: 2024, Номер unknown, С. 100003 - 100003
Опубликована: Дек. 1, 2024
Язык: Английский
ACS Catalysis, Год журнала: 2024, Номер 14(4), С. 2746 - 2757
Опубликована: Фев. 7, 2024
Remote stereocontrol in transition-metal catalysis is a challenging but interesting research topic. In this work, we achieved copper-catalyzed asymmetric yne-allylic substitution using electron-rich arenes and acyclic carbonates through remote enantioselectivity control. The reaction delivers variety of enantioenriched products that contain diverse set valuable moieties, such as conjugated enynes, indoles, indolizines, allenes, dihydrofurans, which are widely used organic synthesis act key units bioactive molecules natural products. synthetic value protocol has been demonstrated series further transformations, mechanistic studies have conducted to gain more insight into the reaction.
Язык: Английский
Процитировано
23
Chemical Communications, Год журнала: 2024, Номер 60(31), С. 4210 - 4213
Опубликована: Янв. 1, 2024
The unprecedented copper-catalyzed asymmetric alkynylallylic monofluoroalkylation reaction is described
Язык: Английский
Процитировано
13
ACS Catalysis, Год журнала: 2024, Номер 14(12), С. 9254 - 9264
Опубликована: Июнь 3, 2024
Catalytic asymmetric dearomatization reactions of α-unsubstituted β-naphthols are very challenging due to the high energy barrier resulting from loss aromaticity. Herein, we describe an example enantioselective catalytic dearomative spiroannulation with yne-allylic esters. The success this reaction relied on copper-catalyzed remote strategy using esters as bis-electrophilic reagents. This transformation features mild conditions, broad functional group tolerance, and extensive substrate scope, thereby facilitating efficient construction array enantioenriched naphthalene-2-one spiroindolenine derivatives. Experimental studies density theory calculations establish pathway origin stereoselectivity.
Язык: Английский
Процитировано
12
Tetrahedron Chem, Год журнала: 2024, Номер 11, С. 100082 - 100082
Опубликована: Июль 3, 2024
Язык: Английский
Процитировано
11
ACS Catalysis, Год журнала: 2025, Номер unknown, С. 2415 - 2423
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
1
Organic Letters, Год журнала: 2024, Номер 26(27), С. 5758 - 5763
Опубликована: Июль 1, 2024
Anthrones are key structural motifs in many natural products and pharmaceutical chemicals. However, due to its unique tricyclic aromatic structure, the synthetic space for development of chiral anthrone derivatives is largely limited. By utilizing potential copper-catalyzed remote asymmetric yne-allylic substitution reaction, we describe first example highly regio- enantioselective on various esters with anthrones under a mild reaction condition, which afforded range enantioenriched 1,3-enynes exhibiting broad functional group tolerance across 51 examples.
Язык: Английский
Процитировано
7
Organic Letters, Год журнала: 2024, Номер 26(30), С. 6407 - 6412
Опубликована: Июль 19, 2024
Chiral coumarins and their derivatives are ubiquitous structural motifs found in an array of biologically therapeutically active natural products drugs. Herein, a highly enantioselective dual remote copper-catalyzed vinylogous alkynylallylic substitution yne-allylic esters with has been developed. The practicality this method is exemplified by the use readily available starting materials; mild reaction conditions; excellent regio-, enantio-, stereoselectivities; very broad substrate scope (67 examples), while scalability further applications illustrated gram-scale series derivations products.
Язык: Английский
Процитировано
7
ACS Catalysis, Год журнала: 2024, Номер 14(15), С. 11646 - 11656
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
7
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110114 - 110114
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
6