In Silico Prediction of Alkaline Phosphatase Interaction with the Natural Inhibitory 5-Azaindoles Guitarrin C and D DOI Creative Commons
Aleksandra Seitkalieva, Yulia Noskova, Marina P. Isaeva

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5701 - 5701

Published: Dec. 3, 2024

The natural 5-azaindoles, marine sponge guitarrin C and D, were observed to exert inhibitory activity against a highly active alkaline phosphatase (ALP) CmAP of the PhoA family from bacterium

Language: Английский

Unveiling sultam in drug discovery: spotlight on the underexplored scaffold DOI
Yie Kie Chong,

Yee Swen Ong,

Keng Yoon Yeong

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(6), P. 1798 - 1827

Published: Jan. 1, 2024

Decades ago, the application of cyclic sulfonamide (sultam) and its derivatives primarily focused on their antibacterial properties. However, recent years have seen a shift in research attention towards exploring potential as anticancer, anti-inflammatory, antidiabetic, antiviral agents. Despite this broadening scope, only few sultam drugs made it to commercial market, much sultams remains discovery phase. This class compounds holds significant promise pertinent pharmaceutical research. Due sultam's relevance growing importance drug discovery, review paper aims consolidate examine biological activities ranging from 4 8-membered ring structures.

Language: Английский

Citations

6
Synthesis, anti-inflammatory, antibacterial, and antioxidant evaluation of novel pyrazole-linked hydrazone derivatives DOI
Vinuta Kamat,

K. D. Venuprasad,

A.J. Shadakshari

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138634 - 138634

Published: May 14, 2024

Language: Английский

Citations

6
Antimicrobial activity of novel substituted 1,2,4-triazole and 1,3-thiazole derivatives DOI
Sana Saffour, Amal A. AL-Sharabi, Asaf Evrim Evren

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1295, P. 136675 - 136675

Published: Sept. 16, 2023

Language: Английский

Citations

12
Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations DOI Creative Commons
Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 22, 2025

TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and overexpressed in different types cancers. Therefore, this study aims disover potential TMPRSS4 inhibitors that have better binding affinity than the approved inhibitors: 2-hydroxydiarylamide tyroserleutide. Since no 3D-structure known for structural models domain were developed. The modeled structures validated subjected molecular dynamics simulations. FDA-approved, clinical/preclinical drugs natural products docked pocket TMPRSS4. Moreover, through systematic analysis, MD simulations MM-GBSA free energy calculations revealed best candidates Ergotamine, S55746, NPC478048, Lifirafenib, NPC77101 are highly stable drug complex displaying low RMSD RMSF values strong stability. Among these compounds, Ergotamine showed most favorable (-33.73 kcal/mol). Overall, our silico results compounds could act as potent need be by future experimental studies.

Language: Английский

Citations

0
Advancements in DNAzyme-based biosensors for the detection of hazardous substances in foodstuff: current applications and future perspectives DOI

Taolin Li,

Yijia Zhang, Weiwei Cheng

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: April 6, 2025

DNAzyme-based biosensors have emerged as a promising tool for ensuring food safety due to their high sensitivity, specificity, and potential rapid, cost-effective detection of hazardous substances. These leverage DNAzymes-catalytically active DNA molecules-to detect range contaminants, including metal ions, fungal toxins, pesticides, pathogens. While show significant advantages over conventional techniques, challenges such nuclease degradation, interference from complex sample matrices, the costs associated with DNAzyme synthesis still hinder widespread application. Recent advancements in stability DNAzymes, immobilization strategies, integration nanomaterials are progressively addressing these limitations, enhancing performance reliability sensors. This review highlights structural catalytic characteristics assesses current applications safety, discusses innovative strategies overcome existing challenges. The continuous evolution biosensors, particularly design device integration, holds great promise future role routine, reliable analysis.

Language: Английский

Citations

0
Hydrogel-Embedded Platinum–Ruthenium Alloy Peroxidase Mimic as a Visual Sensor for “Signal-on” Alkaline Phosphatase Detection DOI
Bo Zhang, Yining Gong, Lan Liu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(10), P. 11248 - 11257

Published: May 10, 2024

Nanozyme-assisted alkaline phosphatase (ALP) assay is a commonly used detection technique. However, this type of sensor faces several challenges, including "signal-off" model, dependence on oxidase mimics, and the need for spectrometers. In study, by optimizing stabilizers, we obtain chitosan-coated platinum–ruthenium nanoparticles (CS-Pt/Ru NPs) first time, which have superior peroxidase (POD) mimic activity. CS-Pt/Ru nanozymes can catalyze phenol oxidation in presence 4-aminoantipyrine hydrogen peroxide to produce an enhanced red color, while be obtained ALP-mediated hydrolysis. Thus, ALP activity quantified absorbance "signal-on" model. This approach demonstrates remarkably low limit (0.01 U·L–1) wide linear range (0.03–10 U·L–1). addition, combine with hydrogel form CS-Pt/Ru@Gel sensor, enables visual using smartphone. It detect as 0.1 U·L–1, 0.15–10 U·L–1. Finally, both Pt/Ru NPs Pt/Ru@Gel are successfully employed clinical blood samples. Our study develops excellent hydrogel-supported POD nanozyme system paves way

Language: Английский

Citations

3
Identifying alkaline phosphatase inhibitory potential of cyclooxygenase-2 inhibitors: Insights from molecular docking, MD simulations, molecular expression analysis in MCF-7 breast cancer cell line and in vitro investigations DOI
Saddam Hussain,

Ambar Iqbal,

Sujhla Hamid

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 132721 - 132721

Published: May 28, 2024

Language: Английский

Citations

3
The synthesis of O/S-heterocycles starting from β-nitrostyrenes: A recent update DOI
Chunmei Li, Kai Yin, Xiang Zhou

et al.

Tetrahedron, Journal Year: 2023, Volume and Issue: 149, P. 133717 - 133717

Published: Nov. 2, 2023

Language: Английский

Citations

7
Toward the Point-of-Care Testing of Alkaline Phosphatase in Human Serum DOI

Zachary Lucio-Rivera,

Robert Gudgel, Waldemar Górski

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 265, P. 116694 - 116694

Published: Aug. 23, 2024

Language: Английский

Citations

2
Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights DOI Creative Commons
Nafeesa Naeem, Amina Sadiq, Mohamed I. A. Othman

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(48), P. 35769 - 35970

Published: Jan. 1, 2024

Heterocyclic compounds represent a prominent class of molecules with diverse pharmacological activities.

Language: Английский

Citations

1