ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
MXenes
are
among
the
most
diverse
and
prominent
2D
materials.
They
being
explored
in
almost
every
field
of
science
technology,
including
biomedicine.
In
particular,
they
investigated
for
photothermal
therapy,
drug
delivery,
medical
imaging,
biosensing,
tissue
engineering,
blood
dialysis,
antibacterial
coatings.
Despite
their
proven
biocompatibility
low
cytotoxicity,
genotoxicity
has
not
been
addressed.
To
investigate
whether
interfere
with
DNA
integrity
cultured
cells,
we
loaded
cells
examined
fragmentation
chromosomal
by
a
comet
assay.
The
presence
both
Ti3C2Tx
Nb4C3Tx
generated
comets,
suggesting
strong
genotoxic
effect
murine
melanoma
human
fibroblast
cells.
However,
no
corresponding
cytotoxicity
was
observed,
confirming
that
were
well
tolerated
lateral
size
MXene
flakes
critical
developing
comets;
submicrometer
induced
while
larger
did
not.
induce
comets
dead
Moreover,
extraction
from
MXene-loaded
or
mixing
purified
showed
signs
fragmentation.
Unconstrained
living
show
cleavage
under
electrophoresis
conditions.
Thus,
assay
ability
particles
to
penetrate
applied
field.
probable
mechanism
formation
is
rotation
movement
inside
an
electric
field,
leading
shredding
MXene's
razor-sharp
edges.
Under
all
other
conditions
interest,
titanium-
niobium-carbide-based
excellent
genotoxicity.
These
findings
may
contribute
development
strategies
cancer
therapy.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(18), P. 4307 - 4334
Published: Jan. 1, 2024
Recent
advancements
pertaining
to
the
application
of
GQD-based
nanosystems
in
photothermal
and
photodynamic
cancer
therapies
are
discussed,
highlighting
crucial
challenges,
advantages,
future
perspectives.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(13), P. 9080 - 9098
Published: Jan. 1, 2024
Two
novel
metal–organic
frameworks
(MOFs),
synthesized
from
4,6-diamino-2-pyrimidinethiol
with
Zn
and
Co
metal
ions,
display
antibacterial,
antibiofilm,
antioxidant
properties,
serving
multifunctionality
in
biological
environmental
domains.
Case Studies in Chemical and Environmental Engineering,
Journal Year:
2024,
Volume and Issue:
10, P. 100828 - 100828
Published: June 27, 2024
A
series
of
bimetallic
metal-organic
frameworks
(MOFs)
photocatalysts
had
been
successfully
synthesized
by
doping
nickel
(Ni)
into
zeolitic
imidazolate
framework-8
(ZIF-8)
for
enhanced
photodegradation
methylene
blue
(MB).
Optical
characterization
revealed
that
the
Ni-ZIF-8
composites
possessed
a
narrower
bandgap
and
lower
recombination
rate
charge
carriers
than
pristine
ZIF-8.
The
Ni(20)-ZIF-8
composite
showed
highest
MB
efficiency
up
to
93.22
%
in
150
min,
with
use
30
mg
photocatalyst,
50
mL
mg/L
solution,
neutral
pH.
scavenger
test
clearly
proved
h+
•OH
were
main
active
species.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 603 - 603
Published: April 29, 2024
Sonodynamic
therapy
(SDT)
has
attracted
significant
attention
in
recent
years
as
it
is
an
innovative
approach
to
tumor
treatment.
It
involves
the
utilization
of
sound
waves
or
ultrasound
(US)
activate
acoustic
sensitizers,
enabling
targeted
drug
release
for
precise
This
review
aims
provide
a
comprehensive
overview
SDT,
encompassing
its
underlying
principles
and
therapeutic
mechanisms,
applications
nanomaterials,
potential
synergies
with
combination
therapies.
The
begins
by
introducing
fundamental
principle
SDT
delving
into
intricate
mechanisms
through
which
facilitates
A
detailed
analysis
presented,
outlining
how
effectively
destroys
cells
modulating
mechanisms.
Subsequently,
this
explores
diverse
range
nanomaterials
utilized
highlights
their
specific
contributions
enhancing
treatment
outcomes.
Furthermore,
combine
other
modalities
such
photothermal
(PTT)
chemotherapy
discussed.
These
combined
approaches
aim
synergistically
improve
efficacy
while
mitigating
side
effects.
In
conclusion,
emerges
promising
frontier
that
offers
personalized
effective
options
revolutionize
patient
care.
As
research
progresses,
poised
play
pivotal
role
shaping
future
landscape
oncology
providing
patients
broader
spectrum
efficacious
tailored
options.
