Synthesis, In Vitro α-Amylase Inhibition Activity and Molecular Docking of some Coumarin Derivatives DOI

Emna Chaabouni,

Ines Dhouib,

Emna Khdhiri

et al.

Chemistry Africa, Journal Year: 2024, Volume and Issue: 7(6), P. 3109 - 3118

Published: July 9, 2024

Language: Английский

Unveiling the Cyclopropyl Appended Acyl Thiourea Derivatives as Antimicrobial, α-Amylase and Proteinase K Inhibitors: Design, Synthesis, Biological Evaluation, Molecular Docking, DFT and ADMET Studies DOI

H. Fahrul Zaman,

Aamer Saeed, Hammad Ismail

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110304 - 110304

Published: Jan. 1, 2025

Language: Английский

Citations

1
Verbascoside and rare flavone glucosides from Citharexylum spinosum L. flowers as antihyperglycemic agents: Isolation, α-amylase inhibition, molecular docking and drug-likeness prediction DOI
Ilyes Saidi, Wiem Baccari,

Safa Teka

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138529 - 138529

Published: May 3, 2024

Language: Английский

Citations

2
Evaluation of the Anti-diabetic Activity of Purified Compounds of Ferula assafoetida by in vitro and in silico Methods DOI Creative Commons

Fatemeh Erfani,

Faegheh Farhadi, Mehrdad Iranshahi

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(6)

Published: June 1, 2024

Objective Postprandial hyperglycemia is considered an early sign of diabetes. Enzyme inhibitors, such as α-amylase and α-glucosidase are currently being studied potential drugs for preventing postprandial hyperglycemia. Methods In this study, we investigated the effects four purified 7-hydroxycoumarine derivatives from Ferula assafoetida: umbelliprenin, farnesiferol A, C, samarcandin. We evaluated cell toxicity using MTT method also examined glucose uptake inhibition enzymes in vitro. Additionally, conducted a molecular docking study to investigate mechanism enzyme inhibition. Results The terpenoid coumarin (umbelliprenin, samarcandin) on HepG2 cells was found be approximately 28 37 µg/ml. assay showed that these compounds (at concentration 25 µg/ml) were able increase consumption by level comparable positive control (metformin at 50 µg/ml). Furthermore, umbelliprenin significantly inhibited activity (by 35.07% 4.98%, respectively). Molecular results indicated with farnesyl chain, had more potent inhibitory effect. Conclusion Our findings suggest may valuable compound controlling However, further vivo studies clinical trials necessary validate effects. While research offers development effective structures, needed confirm findings.

Language: Английский

Citations

0
Synthesis, In Vitro α-Amylase Inhibition Activity and Molecular Docking of some Coumarin Derivatives DOI

Emna Chaabouni,

Ines Dhouib,

Emna Khdhiri

et al.

Chemistry Africa, Journal Year: 2024, Volume and Issue: 7(6), P. 3109 - 3118

Published: July 9, 2024

Language: Английский

Citations

0