Aquaculture Reports, Journal Year: 2024, Volume and Issue: 39, P. 102509 - 102509
Published: Nov. 16, 2024
Language: Английский
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)
Published: Jan. 16, 2025
Language: Английский
Citations
2
Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Language: Английский
Citations
1
Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9
Published: Jan. 28, 2025
This study aimed to design a novel liposome containing GA modified phosphatidylcholine lipid (GA-PC Lip) and determine its susceptibility tumor over-expressed secretory phospholipase A2 (sPLA2) anti-cancer effect compared conventional liposomes (Convention Lip). The were characterized for size, drug loading, encapsulation efficiency, stability. A 6-CF release assay was conducted assess the sensitivity of tumor-overexpressed (sPLA2). In vitro experiment, sPLA2 levels in Colo205 cell culture medium detected by Elisa kit oxaliplatin (L-OHP) loaded GA-PA Lip analyzed CCK-8 assay. Results showed that both L-OHP formulations Convention had similar particle sizes ∼100 nm close entrapment efficiency values 4.5-4.8%. results CF indicated labeled GA-PC released more quickly than presence Bv about 95% at 2 h, whereas only 13% 6-CF. addition, average concentrations cell-conditioned (CCM) cancer cells increased with incubation time much greater anti-proliferative activity against cells. These findings suggest is an ideal complex sPLA2-triggered has potential applications enzyme-triggered smart system increase effect.
Language: Английский
Citations
0
Food Innovation and Advances, Journal Year: 2025, Volume and Issue: 4(1), P. 108 - 115
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3237 - 3237
Published: March 31, 2025
Gastric ulcer (GU) is a prevalent gastrointestinal disorder impacting millions worldwide, with complex pathogenic mechanisms that may progress to severe illnesses. Conventional therapies relying on anti-secretory agents and antibiotics are constrained by drug abuse increased bacterial resistance, highlighting the urgent need for safer therapeutic alternatives. Natural medicinal compounds, particularly triterpenoids derived from plants herbs, have gained significant attention in recent years due their favorable efficacy reduced toxicity profiles. Emerging evidence indicates exhibit potent anti-ulcer properties across various experimental models, modulating key pathways involved inflammation, oxidative stress, apoptosis, mucosal protection. Integrating current knowledge of these bioactive compounds facilitates development natural triterpenoids, addresses challenges clinical translation, deepens mechanistic understanding GU pathogenesis, drives innovation strategies GU. This review comprehensively evaluates research treatment since 2000, discussing biological sources, structural characteristics, pharmacological activities, action, animal models employed studies, limitations, associated application.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Comprehensive Summary Natural products with high oxidation states and complex chemical skeletons exhibit diverse bioactivities due to their unique interactions biological targets. The state is characterized by the presence of multiple oxygen‐containing functional groups such as hydroxyl groups, carbonyl epoxides that are usually tough construct selectively. In recent years, thanks development efficient strategies sophisticated methodologies, significant advancements have been made in total syntheses highly oxidized natural (HONPs). this review, we highlight examples HONPs focusing on tetrodotoxin (TTX) its derivatives, steroidal alkaloids, sesquiterpenes, diterpenoids since 2019. Key Scientists 2005, Yang group applied thioureas ligands Pauson−Khand reaction for synthesis triterpene products. methodological advances achieved a series topologically structural features following years. 2009, Baran established pioneering “two‐phase” approach terpenes, an innovative strategy has inspired numerous field. 2011, Xu Theodorakis (−)‐jiadifenolide, sesquiterpene from Illicium . 2012, Li 6π electrocyclization containing aromatic rings. 2014, Inoue introduced α‐alkoxy bridgehead radical, facilitating unified ryanodane diterpenoids. subsequent radical‐based convergent were employed assembling HONPs. developed type ΙΙ [5+2] reaction, which can be efficiently featuring bridged ring systems. Reisman presented pattern analysis guided synthetic designs complex, isoryanodane diterpenes. 2017, Gao reported photoenolization/Diels‐Alder (PEDA) constructing related polycyclic rings elevated states. 2018, Ding unprecedented oxidative dearomatization‐induced (ODI) cycloaddition/pinacol‐ 1,2‐acyl migration cascade assemble oxygenated bicyclo[3.2.1]octane system, was subsequently grayanane same year, Gui explored “bioinspired” strategic transformations enabled rapid construction core framework steroid terpenoid 2020, Luo successfully synthesized several HONPs, including (−)‐batrachotoxinin, (−)‐zygadenine, diterpenoids, employing elegant strategies. 2021, Zhang site‐specific photochemical desaturation late‐stage skeletal reorganization strategies, enabling divergent sesquiterpenes. 2022, Jia first (−)‐principinol C, accomplished six More recently, Trauner concise tetrodotoxin, particularly strategy.
Language: Английский
Citations
0
Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1134 - 1162
Published: Dec. 1, 2024
Language: Английский
Citations
1
Microbiology Research, Journal Year: 2024, Volume and Issue: 15(4), P. 1993 - 2006
Published: Sept. 29, 2024
The search for novel plant-based antioxidant and antibacterial medication has garnered a lot of attention lately. Glycyrrhiza glabra, known as licorice, is one the most important medicinal plants. primary component glabra glycyrrhizin, which biotransformed into 18α- 18β-glycyrrhetinic acid variety purposes. goal this study was to improve bioavailability glycyrrhizin by its biotransformation glycyrrhetinic Aspergillus niger. process optimized using response surface methodology. A two-level Plackett–Burman design employed identify factors that had significant impact on biotransformation. three main variables were pH, glycerrhizin concentration, incubation time. These medium components further 3-level Box–Behnken design, their optimum levels pH 8, an period 6 days, concentration 1%. Using these conditions, maximum level obtained 159% greater than in screening experiment. Regarding antimicrobial activity extract, Bacillus subtilis emerged sensitive organism with lowest MIC (60 µg/mL) highest zone inhibition (17 mm). resistant Pseudomonas aeruginosa, (400 smallest (10 In case acid, (32 mm) (20 µg/mL). aeruginosa organism, (18 mm), (140 extract increased from 12.81% at 63 µg/100 µL 41.41% 1000 µL, while 35.5% 76.85% µL. present concluded activities. Glycyrrhizin might be used natural pharmaceutical industries
Language: Английский
Citations
0
Aquaculture Reports, Journal Year: 2024, Volume and Issue: 39, P. 102509 - 102509
Published: Nov. 16, 2024
Language: Английский
Citations
0