Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(48), P. 14092 - 14099
Published: Jan. 1, 2023
1,2-Disubstituted
bicyclo[2.1.1]hexanes
have
been
synthesized,
characterized,
and
biologically
validated
as
saturated
bioisosteres
of
the
ortho
-substituted
benzene
ring.
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
13(5)
Published: Feb. 21, 2024
Abstract
Within
a
medicinal
chemist's
toolbox,
one
of
the
most
effective
strategies
to
improve
overall
properties
biologically
active
compound
is
bioisosteric
replacement.
Ever
since
first
example
replacing
benzene
with
bicyclo[1.1.1]pentane
(BCP)
group
was
published
in
late
1990s,
[1]
chemistry
community
has
continually
been
expanding
scope
such
phenyl
replacements.
Recent
interest
from
academia
focused
on
novel
synthetic
access
C(
sp
3
)‐rich
bicyclic
hydrocarbons
expanded
ring
sizes.
Herein,
we
summarize
some
these
transformations
and
reveal
that
rely
strain
releasing
cycloadditions
bicyclo[1.1.0]butane
(BCB)
bicyclo[2.1.0]pentane
(housane).
We
have
organized
this
review
based
mechanism
release
strategies,
namely,
carbene
cycloadditions,
energy
transfer
photocatalyzed
electron
catalyzed
polar
cycloadditions.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(8), P. 2746 - 2766
Published: Aug. 8, 2024
Photocatalysis
is
a
versatile
and
rapidly
developing
field
with
applications
spanning
artificial
photosynthesis,
photo-biocatalysis,
photoredox
catalysis
in
solution
or
supramolecular
structures,
utilization
of
abundant
metals
organocatalysts,
sustainable
synthesis,
plastic
degradation.
In
this
Perspective,
we
summarize
conclusions
from
an
interdisciplinary
workshop
young
principal
investigators
held
at
the
Lorentz
Center
Leiden
March
2023.
We
explore
how
diverse
fields
within
photocatalysis
can
benefit
one
another.
delve
into
intricate
interplay
between
these
subdisciplines,
by
highlighting
unique
challenges
opportunities
presented
each
multidisciplinary
approach
drive
innovation
lead
to
solutions
for
future.
Advanced
collaboration
knowledge
exchange
across
domains
further
enhance
potential
photocatalysis.
Artificial
photosynthesis
has
become
promising
technology
solar
fuel
generation,
instance,
via
water
splitting
CO
Nanoscale,
Journal Year:
2023,
Volume and Issue:
16(1), P. 123 - 137
Published: Nov. 29, 2023
An
energy
transfer
cascade
in
a
three-component
upconversion
system
improves
the
emission
quantum
yield
and
reduces
intrinsic
filter
effects.
Investigations
of
molecular
interactions
are
combined
with
lab-scale
applications
photocatalysis.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(12), P. 3421 - 3426
Published: Jan. 1, 2024
The
synthesis
of
gem
-difluoro-1,5-dienes
via
regioselective
S
N
2′-type
reactions
alkylidene
malonates
with
trifluoromethyl
alkenes
and
their
subsequent
[2
+
2]
photocycloaddition
for
the
formation
bicyclo[2.1.1]hexanes
are
described.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(29), P. 19828 - 19838
Published: July 9, 2024
In
recent
years,
methodologies
that
rely
on
water
as
the
reaction
medium
have
gained
considerable
attention.
The
unique
properties
of
micellar
solutions
were
shown
to
improve
regio-,
stereo-,
and
chemoselectivity
different
transformations.
Herein,
we
demonstrate
aqueous
environment
is
a
suitable
for
visible
light
driven
cobalt-catalyzed
involving
radical
species.
this
system,
reduced
vitamin
B
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
13(3)
Published: Jan. 10, 2024
Abstract
Over
the
last
century
UV‐light
mediated
processes
gave
access
to
synthetically
valuable
products.
Some
of
disadvantages
encountered
when
performing
such
triggered
synthetic
reactions
are
necessity
for
special
glassware
(quartz),
environmentally
unfriendly
irradiation
sources
and
need
oxygen
removal,
often
via
time
consuming
freeze‐pump‐thaw
cycles.
In
addition,
penetration
into
reaction
mixture
is
a
challenge
due
absorption
effects
scattering.
A
solution
these
could
be
triplet‐triplet
annihilation
upconversion
performed
under
micellar
conditions.
Hereby,
can
generated
in
using
visible
light
irradiation.
aqueous
medium
allow
process
occur
without
removal.
This
concept
has
been
sporadically
demonstrated
holds
great
promise
development
promoted
photochemical
milder
more
benign
conditions
that
may
eventually
scale
up
protocols.
ChemPhotoChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 23, 2024
Abstract
Oxygen
removing
protocols
have
long
been
the
standard
approach
to
perform
photoreactions.
By
encapsulating
photosensitizers
and
reactants
in
tailored
supramolecular
assemblies,
preservation
of
photoreactivity
even
presence
molecular
oxygen
can
be
observed.
Herein,
we
showcase
some
solutions
that
could
render
time‐consuming
removal
redundant
photochemical
synthesis.
A
focus
has
dedicated
aqueous
assemblies
as
potential
reaction
media.
They
present
an
attractive
solution
possibly
useful
not
only
for
synthetic
transformations,
but
also
water
purification,
bio‐applications
or
biocatalysis.
The
included
media
are
membranes,
hydrogels,
deep
eutectic
solvents
peptide
assemblies.
In
recent
years,
methodologies
that
rely
on
water
as
the
reaction
medium
have
gained
considerable
attention.
The
unique
properties
of
micellar
solutions
were
shown
to
improve
regio-,
stereo-,
and
chemoselectivity
different
transformations.
Herein,
we
demonstrate
aqueous
environment
is
a
suitable
for
visible
light
driven
cobalt-catalyzed
involving
radical
species.
this
system,
reduced
vitamin
B12
reacts
with
alkyl
halides,
gen-erating
radicals
are
trapped
by
lipophilic
olefin
present
in
Stern
layer.
A
series
NMR
measurements
theoretical
studies
revealed
location
components
system.
