Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 31, 2024
Abstract
Functional
group
interconversion
is
of
great
significance
in
organic
synthesis.
However,
aerobic
cleavage
C=N
bonds
to
access
carbonyl
compounds
still
suffered
from
some
limitations
such
as
harsh
reaction
conditions,
stoichiometric
oxidants,
poor
substrate
scope
and
use
toxic
reagents.
Herein,
we
report
a
catalyst‐free
photo‐induced
afford
diverse
using
oxygen
air
green
oxidant.
This
mild
methodology
permits
N
‐tosylhydrazones
converted
into
the
corresponding
including
ketones,
aldehydes
carboxylic
acids,
showing
broad
functional
tolerance
compatibility.
Moreover,
gram‐scale
post‐modification
complicated
molecules
proved
applicability
efficiency
this
strategy.
Finally,
plausible
mechanism
was
proposed
based
on
spectroscopic
investigations
detailed
mechanistic
studies.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(8), P. 4600 - 4608
Published: Jan. 1, 2024
A
metal-free
and
catalyst-free
strategy
is
reported
to
achieve
N–H
insertions
by
coupling
N
-tosylhydrazones
with
diverse
amines
including
aminopyridines,
anilines,
aliphatic
amines,
other
nucleophiles
such
as
imidazoles
indoles.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(15), P. 3130 - 3134
Published: April 8, 2024
Isoxazolines
and
isoxazoles
commonly
serve
as
core
structures
of
many
therapeutic
agents
natural
products.
However,
the
metal-free
catalysis-free
strategy
for
synthesis
these
privileged
motifs
at
room
temperature
remains
a
challenging
task.
Herein,
we
report
three-component
to
afford
diverse
isoxazolines
via
[3
+
2]
cycloadditions
in
situ-formed
nitronates
olefins/alkynes
under
visible-light
irradiation.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(20), P. 2796 - 2799
Published: Jan. 1, 2024
We
report
light-induced
arylation
(alkylation)
for
the
synthesis
of
diarylmethanes,
bis(diarylmethyl)benzenes,
arylalkylmethanes,
and
triarylmethanes
from
readily
accessible
N
-sulfonylhydrazones
aryl/alkylboronic
acids
with
aid
Cs
2
CO
3
.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(5), P. 965 - 969
Published: Jan. 1, 2024
A
visible-light-induced,
electron
donor–acceptor
(EDA)
complex-enabled
decarboxylative
cascade
reaction
of
acryloylbenzamides
with
alkyl
N
-hydroxyphthalimide
esters
by
NaI/PPh
3
catalysis
was
developed.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(47), P. 13765 - 13775
Published: Jan. 1, 2023
The
homologation
of
boronic
acids
with
diazoalkanes
obtained
by
photochemical
decomposition
N
-tosylhydrazones
leads
to
substituted
benzylboronates,
previously
unavailable
under
thermal
conditions.
Batch
and
continuous
flow
reactions
are
described.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 3, 2024
A
highly
regioselective
photocatalytic
method
to
access
a
variety
of
biaryl
motifs
under
metal-free
conditions
has
been
developed.
The
organophotocatalyst
is
involved
in
π–π
stacking
interactions
with
the
alkyne
species,
which
promotes
this
process
thiophene.
Mechanistic
studies
have
shed
light
on
these
and
overall
process.
Along
broad
functional-group
tolerance
excellent
regioselectivity,
protocol
utilized
late-stage
functionalization
pharmaceuticals
other
natural
products.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(19), P. 4031 - 4036
Published: Jan. 26, 2024
We
present
a
new
[3+2]
cycloaddition
reaction
between
alkyl-acceptor
diazoalkanes
under
visible
light
irradiation.
By
employing
easily
accessible
alkyl-acceptor-type
or
their
precursor
hydrazones
as
both
1,3-dipoles
and
dipolarophiles,
diverse
range
of
pyrazoline
derivatives
featuring
quaternary
center
have
been
efficiently
synthesized
in
predictable
manner,
with
excellent
functional
group
tolerance
good
yields.
Furthermore,
scale-up
experiments
downstream
transformations
the
product
were
also
detailed.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(11), P. 3080 - 3088
Published: Jan. 1, 2024
Herein,
we
describe
a
non-covalent
complex-mediated
epoxidation
strategy
that
can
yield
highly
selective
central
spiro-epoxides
by
irradiation
with
visible
light
without
the
need
for
catalyst
addition.
