The Diketopyrrolopyrrole (DPP) Core as a Gel-Forming Material: Current Status and Untapped Potential

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 134 - 134

Published: Feb. 13, 2025

The diketopyrrolopyrrole (DPP) core is widely recognized for its applications in organic electronics and photonics due to exceptional electronic optical properties. Recently, DPP-based materials have shown remarkable π-π stacking interactions tunable self-assembly, making them promising candidates gel formation. However, the development of gels remains infancy, primarily hindered by challenges such as limited gelation efficiency, poor mechanical robustness, sensitivity environmental conditions. Overcoming these issues crucial unlocking their full potential functional soft materials. This review compiles analyzes existing studies on DPP-containing systems, highlighting structural versatility, self-assembly mechanisms, advantages over conventional gelators. By examining works, we identify key strategies DPP formation, evaluate physicochemical performance, discuss innovative approaches address current limitations. Finally, propose future research directions advance field establish a robust platform next-generation

Language: Английский

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Nanoscale assembly of enantiomeric supramolecular gels driven by the nature of solvents

Nanoscale, Journal Year: 2024, Volume and Issue: 16(18), P. 8922 - 8930

Published: Jan. 1, 2024

Different co-assembly modes depending on the nature of solvents observed in multi-component systems with structurally similar components.

Language: Английский

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Metal-polymer-coordinated complexes: An expedient class of hybrid functional materials

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216286 - 216286

Published: Nov. 8, 2024

Language: Английский

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Supramolecular Gels Based on C3-Symmetric Amides: Application in Anion-Sensing and Removal of Dyes from Water

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2149 - 2149

Published: May 5, 2024

We modified C3-symmetric benzene-1,3,5-tris-amide (BTA) by introducing flexible linkers in order to generate an N-centered BTA (N-BTA) molecule. The N-BTA compound formed gels alcohols and aqueous mixtures of high-polar solvents. Rheological studies showed that the DMSO/water (1:1, v/v) were mechanically stronger compared other gels, a similar trend was observed for thermal stability. Powder X-ray analysis xerogel obtained from various revealed packing modes gelators these systems similar. stimuli-responsive properties towards sodium/potassium salts indicated gel network collapsed presence more nucleophilic anions such as cyanide, fluoride, chloride at MGC, but intact when contact with nitrate, sulphate, acetate, bromide, iodide salts, indicating anion-responsive gels. Anion-induced formation less below MGC N-BTA. ability act adsorbent hazardous anionic cationic dyes water evaluated. results ethanolic successfully absorbed methylene blue methyl orange water. This work demonstrates potential gelator material promising candidate purification.

Language: Английский

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Exploiting Urea-Carboxylate Synthon for Designing Supramolecular Topical Hydrogel via Simple Organic Salt Formation: Synthesis, Crystal Structures, and Anticancer Behavior against Melanoma B16–F10 Cells

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(15), P. 7317 - 7331

Published: July 29, 2024

A supramolecular synthon-based crystal engineering approach was adopted to design an exceptional class of gelators utilizing simple organic salt formation between monocarboxylic acid drugs (NSAIDs and 5-fluorouracil acetic or 5F) N,N′-bis(4-pyridyl)urea (4U) reacted in 1:1 2:1 molar ratio, respectively. Among 14 salts, 6 turned be aqueous gelators. In fact, 2_5F·4U, formed by the combination two molecules 5F one molecule 4U having molecular weight <300 produced a pure water gel. Single-crystal X-ray diffraction performed with six salts indicated presence 1D H-bonding networks characteristic synthons as envisaged. Several vitro assays showed that 2_5F·4U effectively induced apoptotic death skin melanoma B16–F10 cells. Along excellent rheoreversibility, hydrogel could shaped into highly stable shape-sustaining translucent patch which placed on adhesive tape for topical applications. The biological studies material properties proved potential topically applicable anticancer agent, highlighting merits proposed rationale designing therapeutic hydrogels reported herein.

Language: Английский

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Photopatterned Hybrid Supramolecular/Polymer Hydrogels for Controlled Heparin Release and Stem Cell Growth

ChemNanoMat, Journal Year: 2024, Volume and Issue: 10(8)

Published: June 1, 2024

Abstract This paper reports hybrid gels combining a low‐molecular‐weight gelator (LMWG) and photoinitiated crosslinked polymer gel (PG). The presence of the PG enhanced stiffness strength gel. were loaded with heparin, in gel, interpenetrated LMWG networks somewhat restricted its release. In terms stem cell growth, significantly improved performance because LMWG, which is an excellent substrate for cells own right. Furthermore, heparin also proliferation over longer timescales. Finally, these photopatterned within well‐plates used tissue culture, patterning helping control proliferation. summary, combine advantageous features both PG: rheological endowed by compatibility provided LMWG. release bioactive agent have capacity to be shaped patterned. Patterned such as these, capable directing potential regenerative medicine.

Language: Английский

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Remarkable Stability of Glutathione-Based Supramolecular Gel in the Presence of Oxidative Stress from Hydrogen Peroxide

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Low molecular weight 7-methoxy-3-(

Language: Английский

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Renewable Resources Derived Glycolipids as a Structuring Agent: A Promising Platform Chemical for Oleogel and Organogel Formation

ACS Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The demand for safe, edible structuring agents across industries such as food, cosmetics, agriculture, pharmaceuticals, and biotechnology has intensified over recent decades. In particular, there is a pressing need to replace trans saturated fatty acids, known contributors cardiovascular other health issues, with healthier alternatives. This study introduces new class of glycolipid-based synthesized from monosaccharides ricinoleic acid, both classified Generally Recognized Safe (GRAS). straightforward synthesis method yields compounds capable self-assembling in various vegetable oils solvents, glycerol, ethylene glycol, poly(ethylene glycol), forming stable oleogels organogels via diverse intermolecular interactions. Morphological investigations using optical microscopy field emission scanning electron (FE-SEM) reveal globular microarchitecture within these molecular gels, 75–150 nm diameters. Rheological analyses confirm the gels' viscoelasticity, thermal processability, thixotropic behavior, supporting their adaptability formulations. These findings underscore potential self-assembled glycolipids 5a 5d, which form versatile, health-conscious significant applications food technology.

Language: Английский

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Fmoc-conjugated dipeptides-based hydrogels and their pH-tuneable behaviour

Soft Matter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Fmoc-dipeptide-based thixotropic, injectable, and biocompatible hydrogels were developed. Hydrogel properties highly dependent on the pH of solution.

Language: Английский

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A Unique Case of ′in Situ’ Bifluoride Triggered Formation of Supramolecular Organogels Using Isophthalamide Hydrogen Bond Donating Receptors.

Chemistry - A European Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract A novel isopthalamide based receptor H 2 L2 featuring two p ‐benzoic acid units has been synthesised and its anion binding properties analysed by 1 H‐NMR spectroscopy in DMSO‐ d 6 /0.5 % O. As expected, the presence of tetrabutylammonium (TBA) fluoride deprotonation carboxylic moieties was observed. However, deprotonated 2− able to bind situ formed HF − via formation H‐bonds with amide NHs. When dissolved THF 4 equivalents TBAF were added CH 3 CN a unique sol‐gel transition occurred giving rise stable thixotropic supramolecular gel. Theoretical calculations elucidated gelation mechanism strongly support findings observed experimentally.

Language: Английский

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