Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins
International Journal of Biological Macromolecules,
Journal Year:
2023,
Volume and Issue:
257, P. 128646 - 128646
Published: Dec. 6, 2023
Language: Английский
Sustainable dressings for wound healing
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
2(1)
Published: Jan. 2, 2025
Abstract
The
field
of
chronic
wound
care
has
been
rapidly
evolving.
With
a
market
size
for
wounds
in
billions
USD,
this
is
not
an
insignificant
area
to
encourage
more
sustainable
practices
and
processes.
sourcing
starting
materials
dressings
from
renewable
resources
the
first
crucial
step
ensuring
that
environmental
impact
minimized.
Next
important
choice
select
methodologies
accordance
with
principles
green
chemistry.
This
involves
utilizing
solvents
as
reaction
media
chemical
processes
preparing
dressing
materials.
In
many
cases,
like
production
hydrogels,
crosslinking
reagents
are
often
employed.
These
can
be,
general,
easily
replaced
by
enzymes
peroxidases,
tyrosinases
sortases.
Process
intensification
strategies
have
emerged
powerful
approach
ensure
economy
sustainability
at
large
scale.
Use
microwave
radiations
ultrasonication
instead
heat
accelerate
rates
helps
cases
inject
wounds.
review
attempts
highlight
ongoing
efforts
future
possibilities
development
cost-effective
methods.
Graphical
Language: Английский
Protein structure–function continuum model: Emerging nexuses between specificity, evolution, and structure
Protein Science,
Journal Year:
2024,
Volume and Issue:
33(4)
Published: March 27, 2024
Abstract
The
rationale
for
replacing
the
old
binary
of
structure–function
with
trinity
structure,
disorder,
and
function
has
gained
considerable
ground
in
recent
years.
A
continuum
model
based
on
expanded
form
existing
paradigm
can
now
subsume
importance
both
conformational
flexibility
intrinsic
disorder
protein
function.
is
actually
critical
understanding
protein–protein
interactions
many
regulatory
processes,
formation
membrane‐less
organelles,
our
revised
notions
specificity
as
amply
illustrated
by
moonlighting
proteins.
While
its
amyloids
prions
often
discussed,
roles
infectious
diseases
under
extreme
conditions
are
also
becoming
clear.
This
review
an
attempt
to
discuss
how
current
function,
specificity,
evolution
fit
better
model.
integration
structure
a
single
may
bring
greater
clarity
continuing
quest
proteins
molecular
mechanisms
their
functionality.
Language: Английский
Decoding the Promiscuous Activity of Bile Salt Hydrolase
Published: Aug. 5, 2024
The
recently
identified
bile
salt
hydrolase
(BSH)
from
gastrointestinal
bacteria
catalyzes
the
formation
of
bacterial
acid
amidates
(BBAAs),
significantly
impacting
host
metabolism.
While
this
activity
was
characterized
as
promiscuous,
underlying
mechanism
not
explored.
This
commentary
proposes
that
BSH
exhibits
condition
promiscuity,
where
typical
hydrolytic
enzymes
catalyze
synthetic
reactions
under
specific
conditions.
Drawing
parallels
with
micellar
enzymology,
we
suggest
salts,
acting
both
substrates
and
micelle-forming
agents,
create
an
environment
conducive
for
to
amidation.
represents
a
potential
first
in
vivo
demonstration
such
mechanism.
Future
investigations
should
explore
BSH-catalyzed
salts
below
critical
micelle
concentrations
alternative
surfactants
validate
hypothesis.
Language: Английский
Decoding the Promiscuous Activity of Bile Salt Hydrolase
Qeios,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
The
recently
identified
bile
salt
hydrolase
(BSH)
from
gastrointestinal
bacteria
catalyzes
the
formation
of
bacterial
acid
amidates
(BBAAs),
significantly
impacting
host
metabolism.
While
this
activity
was
characterized
as
promiscuous,
underlying
mechanism
not
explored.
This
commentary
proposes
that
BSH
exhibits
condition
promiscuity,
where
typical
hydrolytic
enzymes
catalyze
synthetic
reactions
under
specific
conditions.
Drawing
parallels
with
micellar
enzymology,
we
suggest
salts,
acting
both
substrates
and
micelle-forming
agents,
create
an
environment
conducive
for
to
amidation.
represents
a
potential
first
in
vivo
demonstration
such
mechanism.
Future
investigations
should
explore
BSH-catalyzed
salts
below
critical
micelle
concentrations
alternative
surfactants
validate
hypothesis.
Language: Английский