Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 335, P. 103358 - 103358
Published: Nov. 22, 2024
Language: Английский
Materials Today Bio, Journal Year: 2023, Volume and Issue: 25, P. 100932 - 100932
Published: Dec. 28, 2023
Bone fractures and critical-size bone defects are significant public health issues, clinical treatment outcomes closely related to the intrinsic properties of utilized implant materials. Zinc (Zn)-based biodegradable metals (BMs) have emerged as promising bioactive materials because their exceptional biocompatibility, appropriate mechanical properties, controllable biodegradation. This review summarizes state art in terms Zn-based for repair regeneration, focusing on bridging gap between biological mechanism required bioactivity. The molecular underlying release Zn ions from BMs improvement regeneration is elucidated. By integrating considerations specific bioactivity materials, this current research status internal fixation promoting fracture healing, scaffolds regenerating defects, barrier membranes reconstituting alveolar defects. Considering progress made potential applications, challenges directions proposed discussed.
Language: Английский
Citations
37
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150560 - 150560
Published: March 20, 2024
Language: Английский
Citations
12
Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1029 - 1040
Published: March 1, 2024
Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside growing geriatric population. VCFs often result debilitating back pain and decreased mobility. Cement augmentation, minimally invasive surgical technique, is widely used stabilize restore vertebral height. Acrylic-based cements calcium phosphate currently the two primary fill materials utilized for these procedures. Despite their effectiveness, acrylic bone have been associated various intraoperative postoperative incidents impacting VCF treatment. Over past decade, discoveries field of biomedical engineering material science shown advancements toward addressing limitations. This narrative review aims assess potential pitfalls barriers types cements.
Language: Английский
Citations
5
Journal of Materials Research and Technology, Journal Year: 2024, Volume and Issue: 30, P. 8260 - 8276
Published: May 1, 2024
Titanium (Ti) alloys have been widely applied clinically due to their good biocompatibility, corrosion resistance and mechanical stability. However, how improve the weak osteointegration caused by intrinsic bio-inertness has a long-standing puzzle. Osteogenic-related cells, endothelial cells (ECs) macrophages are main involved in osteointegration. In recent years, surface topography based on Ti alloys, which mimics topographical cues of extracellular matrix (ECM), confirmed precisely regulate these cells' fate More importantly, while serving as physicomechanical stimuli, topographic modification is considered more biosafe stable than biochemical cues. Nevertheless, different modifications affect cell behavior specific mechanisms remain elusive. this review, we highlight regulation behaviors bone repair-related such osteogenic-related ECs macrophages, summarize activated intracellular mechanotransduction pathways, aims provide basis support for further research alloys.
Language: Английский
Citations
4
Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 105776 - 105776
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106619 - 106619
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 100 - 100
Published: Feb. 10, 2025
Millions of people request bone regeneration every year, and the market for grafting materials has a positive trend. The most used biomaterials applied to replace regenerate are based on collagen different types ceramics in order mimic natural matrix. However, there lot implant-associated infections after surgery, or implants rejected because reduced biocompatibility, this is why research into graft still challenge. This study aims develop characterize novel biomimetic fillers which have simultaneously both antimicrobial properties biocompatibility with human marrow-derived mesenchymal stem cells (BMSCs). Type I calcium triphosphate ratio 1:1 were as control, according our previous studies, ZnO, functionalized percentages Satureja thymbra L. essential oils, was added an antimicrobial, promoting growth, mineralization, formation. obtained by freeze-drying spongious forms characterized Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), water uptake, biodegradability over time, activity against Staphylococcus aureus Escherichia coli viability proliferation BMSCs. material showed higher porosity interconnected pores, gradual resorption time balance between chosen ideal filler.
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(2), P. 201 - 201
Published: Feb. 18, 2025
Osteoporotic fractures represent a significant public health challenge in the context of an aging global population, with rising prevalence osteoporosis intensifying demand for effective fracture treatment. Restoring structure and function bone tissue damaged by osteoporosis-induced defects remains critical issue clinical practice. In recent years, bioactive metallic materials such as magnesium, zinc, strontium have gained considerable attention due to their exceptional mechanical properties, biocompatibility, biodegradability, positioning them promising osteoporotic repair. This review systematically explored biological mechanisms, application advancements, associated challenges healing. Key topics included roles promoting osteoblast proliferation differentiation, inhibiting osteoclast activity, modulating microenvironment. Additionally, this examined optimization strategies application, integration into scaffolds, functionalization conventional materials, synergistic effects between different metals. Finally, analyzed current progress unresolved issues field, offering forward-looking perspective on potential precision treatment fractures.
Language: Английский
Citations
0
Journal of Biological Engineering, Journal Year: 2025, Volume and Issue: 19(1)
Published: March 14, 2025
Abstract Adipose-derived stem cells (ASCs) provide an ample, easily accessible source of multipotent cells, alternative to bone marrow-derived stromal (BMSCs), capable differentiating into osteoblasts. However, the osteogenic potential ASCs is reportedly lower than that BMSCs and protocols effectively differentiate osteoblasts are in high demand. Here, we present novel strategies for effective differentiation human by combining their culture on bioactive growth surfaces with treatment specific supplements medium application fluid shear stress. Human were cultured PLGA-based composites containing 50 wt% sol-gel glasses (SBGs) from SiO 2 -CaO±P O 5 system, either unmodified or modified ZnO SrO. The was supplemented recombinant morphogenetic protein (BMP-2), MEK1/2 kinase inhibitor (PD98059) indirect Smurf1 (Phenamil). Fluid stress applied a standard horizontal rocker. ASC SBG-PLGA along enhanced expression both early late markers. Modification SBG SrO further gene compared SBGs. Notably, synergistically strengthened effects supplements. We also show presented can drive toward osteoblastic 3-day period mineralizing through short, 7-day preculture composites. Our results indicate leads phosphorylation β-catenin CREB COX-2 expression. believe feasible rapid various cell-based regeneration therapies. Graphical
Language: Английский
Citations
0
Composites Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 111164 - 111164
Published: March 1, 2025
Language: Английский
Citations
0