Cyclodextrin in drug delivery: Exploring scaffolds, properties, and cutting-edge applications

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124485 - 124485

Published: July 17, 2024

Language: Английский

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Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 35 - 35

Published: Jan. 4, 2025

In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) boronic acid linkers into matrix to enhance antibacterial activity against Staphylococcus aureus (S. aureus). We systematically investigated how varying the number free moieties (ranging from two six), along with guanosine β-CD content, influences both structural integrity antimicrobial efficacy these materials. Comprehensive characterization using FTIR, circular dichroism, X-ray diffraction, SEM, AFM, rheological measurements confirmed successful synthesis revealed that higher content correlated stronger, more organized network. The most effective hydrogel displayed an inhibition zone 25 mm in disk diffusion assays, was further explored as drug delivery platform, aim exploit capacity cavity incorporate hydrophobic drugs. Norfloxacin (Nfx), poorly water-soluble antibiotic, successfully encapsulated within through inclusion complex formation β-CD, improving its solubility enabling sustained, targeted release. Nfx-loaded expanded 49 completely eradicated S. cells 24 h, outperforming unloaded Nfx. These results highlight synergistic effect controlled release, underlining potential versatile platforms for localized therapy, such wound dressings or implant coatings. Nevertheless, vivo studies long-term stability assessments are needed fully establish clinical relevance, safety, scalability before systems can be translated routine healthcare applications.

Language: Английский

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Recent Advances in Polysaccharide-Based Hydrogels for Tumor Immunotherapy

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 152 - 152

Published: Feb. 20, 2025

Immunotherapy has revolutionized cancer treatment and led to a significant increase in patient survival rates quality of life. However, the effectiveness current immunotherapies is limited by various factors, including immune evasion mechanisms serious side effects. Hydrogels are type medical material with an ideal biocompatibility, variable structure, flexible synthesis method, physical properties. have long been recognized used as superior choice for biomedical applications. The fascinating results were derived from both vitro vivo models. rapid expansion this area suggests that principles uses functionalized polysaccharides transformative, motivating researchers investigate novel polysaccharide-based hydrogels wider Polysaccharide proven be practicable delivery strategy tumor immunotherapy due their biodegradability, pronounced bioactive characteristics. This study aims examine detail latest developments polysaccharide immunotherapy, focusing on design, mechanism action, potential therapeutic

Language: Английский

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A Comprehensive Review on Supramolecular Polymer Hydrogels for Localized and Long-Term Therapeutic Delivery

Journal of Macromolecular Science Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 3, 2025

Language: Английский

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Removal of cobalt and nickel ions from aqueous solution via batch adsorption technique using cost-effective β-cyclodextrin based smart hydrogel

International Journal of Environmental & Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 24, 2025

Language: Английский

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Wearable Hydrogels for Personal Protection Applications

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

As the Internet of Things and artificial intelligence technologies have advanced, wearable technology has attracted significant attention from academia industry. Hydrogel already received much as an emerging candidate material for devices due to its unique 3D network structure, excellent biocompatibility, soft stretchability. It is aimed here provide a comprehensive overview development hydrogels applications. Here, synthetic methods currently employed in are reviewed first, including physical crosslinking, chemical multiple crosslinking. Then, strategies optimizing performance summarized perspectives mechanical properties, electrical thermal other characteristics such self-healing, self-adhesion. The final section discusses latest advances application personal protection, current shortcomings challenges. it innovative insights further this field by summarizing research hotspots cutting-edge issues hydrogels.

Language: Английский

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Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 627 - 651

Published: March 29, 2025

Language: Английский

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Latest advances in hydrogel therapy for ocular diseases

Polymer, Journal Year: 2024, Volume and Issue: 306, P. 127207 - 127207

Published: May 25, 2024

Language: Английский

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Complexation of telmisartan with cyclodextrins as a tool of solubility enhancement: a comparative analysis of influence of the cyclodextrin type and method of solid dispersion preparation

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135662 - 135662

Published: Oct. 1, 2024

Language: Английский

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Aqueous eye drop formulations: cyclodextrins as enabling excipients

Annales Pharmaceutiques Françaises, Journal Year: 2024, Volume and Issue: 82(6), P. 994 - 1007

Published: Aug. 8, 2024

Language: Английский

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