Nanotechnology in the life sciences, Journal Year: 2024, Volume and Issue: unknown, P. 121 - 151
Published: Jan. 1, 2024
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4211 - 4211
Published: Sept. 5, 2024
Carbon dots (CDs) have garnered extensive interest in basic physical chemistry as well biomedical applications due to their low cost, good biocompatibility, and great aqueous solubility. However, the synthesis of multi-functional carbon has always been a challenge for researchers. Here, we synthesized novel CDs with high quantum yield 28.2% through straightforward hydrothermal method using Diaminomaleonitrile Boc-D-2, 3-diaminopropionic acid. The size, chemical functional group, photophysical properties were characterized by TEM, FTIR, XPS, UV, fluorescence. It was demonstrated this study that prepared yield, excellent photostability, cytotoxicity. Regarding highly water-soluble property CDs, they proven possess selective sensitive behavior against Cu2+ ions (linear range = 0–9 μM limit detection 1.34 μM). Moreover, utilized fluorescent ink anti-counterfeiting measures. Because cytotoxicity also successfully cell imaging. Therefore, as-prepared potential fluorescence sensing, anti-counterfeiting, bioimaging.
Language: Английский
Citations
6
Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Language: Английский
Citations
0
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(3)
Published: Feb. 12, 2025
Abstract Carbon quantum dot (CQD)–based fluorescent nanosensor platforms were developed using gastric cancer-associated Heliobacter pylori ( H. ) genes. N-doped CQDs synthesized two different organic acids (citric acid and malic acid) ethylenediamine by the microwave method. The photophysical photochemical properties of investigated ultraviolet–visible, fluorescence, Fourier-transform infrared spectra. surface was conjugated with single-stranded DNA (ssDNA), which is specific for cancer. Ethidium bromide, a selective dye, shows enhanced fluorescence intensity upon intercalating DNA. In blue-emissive CQD-ssDNA nanoprobe system, quenched ethidium bromide due to Förster resonance energy transfer (FRET) processes. When complementary ssDNA introduced, strongly intercalated newly formed double-stranded DNA, shifting red emission. Using this ratiometric detection method improved cancer–associated genes, achieving limit (LOD) 0.098 µM, within concentration range 1.30 11.49 µM. Spike recovery tests also conducted evaluate precision presented in synthetic saliva solutions, recoveries ranging from 93.06% 101.85% performance nanosensors compared CQDs. Graphical abstract
Language: Английский
Citations
0
JACS Au, Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability
Language: Английский
Citations
0
Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 112914 - 112914
Published: April 1, 2025
Language: Английский
Citations
0
Russian Chemical Bulletin, Journal Year: 2025, Volume and Issue: 74(3), P. 742 - 746
Published: March 1, 2025
Language: Английский
Citations
0
Materials Horizons, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder marked by permanent impairment of brain function across the whole brain. This condition results in deterioration cognitive patients and frequently associated with psychological symptoms such as agitation anxiety, imposing significant burden on both their families. Nanomaterials possess numerous distinctive physical chemical features that render them extensively utilized. In biomedical domain, nanomaterials can be utilized for prevention therapy, including medication delivery systems, biosensors, tissue engineering. article explores etiology potential molecular processes AD, well application carbon-based diagnosis treatment AD. Some are carbon quantum dots, nanotubes, graphene, among others. These materials physicochemical highly promising applications biosensing, drug delivery, neuroprotection, photothermal treatment. addition, this review explored various therapeutic approaches AD terms reducing inflammation, preventing oxidative damage, inhibiting Aβ aggregation. The advent nanotechnology has facilitated development novel disease. strategies provide early diagnosis, effective intervention neuroprotection
Language: Английский
Citations
3
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8807 - 8807
Published: Sept. 30, 2024
The emergence of bio-based carbonaceous materials for various applications has attracted significant attention during the last few years. Here, we report a rapid, efficient, and reproducible microwave-assisted synthesis graphene quantum dots (GQDs) with identical features irrespective nature biomass waste investigated. synthesized GQDs were fully characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared transmission electron microscopy, dynamic light scattering. nanoparticles displayed narrow sizes 1–2 nm high solubility in polar solvents such as water ethanol. protocol described herein is advantageous comparison to dealing from previously reported since our faster owing use microwave heating avoidance dialysis purification step. Furthermore, solution, water-soluble particles showed excitation-dependent photoluminescence ranging blue orange emission wavelengths. Interestingly, thin films white-light under 325 UV-light excitation, while aggregation-induced quenching was usually observed, opening way their potential phosphor white-light-emitting diodes.
Language: Английский
Citations
0
Nanotechnology in the life sciences, Journal Year: 2024, Volume and Issue: unknown, P. 121 - 151
Published: Jan. 1, 2024
Language: Английский
Citations
0