Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140699 - 140699
Published: Nov. 9, 2024
Language: Английский
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140699 - 140699
Published: Nov. 9, 2024
Language: Английский
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
In view of the frequent occurrence carbon-nitrogen bonds in organic compounds, development powerful new methods for construction such is expected to greatly impact many fields that utilize molecules. While substitution an alkyl electrophile by a nitrogen nucleophile seemingly straightforward approach generating bond, practice classical pathways have very substantial limitations case unactivated secondary and tertiary electrophiles. Recent reports transition metals can catalyze certain reactions electrophiles are therefore considerable significance; however, virtually no been developed wherein absolute stereochemistry controlled together with bond formation. Herein, we address this dual challenge reactivity enantioselectivity, describing photoinduced, copper-catalyzed enantioconvergent synthesis β-aminoalcohol derivatives via coupling anilines racemic, β-haloethers. We apply method catalytic asymmetric metolachlor, report array mechanistic studies consistent reaction pathway propose.
Language: Английский
Citations
1Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 26, 2024
Catalytic asymmetric transformation of donor–acceptor cyclopropanes (DACs) has been proven to be a highly valuable and robust strategy construct diverse types enantioenriched molecules. However, the use 1,1,2,2-tetrasubstituted DACs form products bearing quaternary stereocenters remains long-term unsolved challenge. Here, we report copper-catalyzed aminative ring opening tetrasubstituted alkynyl that delivers myriad α-tertiary amines with high levels enantioselectivities. The alkyne, amine, ester moieties within enable further applications, including synthesis bioactive Mechanistic studies indicate zwitterionic intermediate copper-acetylide unit plays key role in process, which represents new mode for achieving catalytic DACs.
Language: Английский
Citations
4Catalysts, Journal Year: 2025, Volume and Issue: 15(4), P. 320 - 320
Published: March 27, 2025
Axially chiral structures have become increasingly common in modern materials and pharmaceuticals, especially as ligands organocatalysts, highlighting their growing significance. In the field of pharmaceutical research, there are several notable examples worth highlighting, such antibiotics vancomycin, Knipholone, Mastigophorene A. Over past decade, availability axially compounds has significantly improved through advancements existing strategies introduction catalytic atroposelective synthesis concepts. These synthetic not only broaden scope chemical reactions, but also facilitate construction frameworks with high application value. Currently, various methods available for achieving stereoselective under catalyst control, including desymmetrization, (dynamic) kinetic resolution, cross-coupling de novo ring-forming synthesis. This paper focuses on recent advances constructing atropisomers palladium-catalyzed asymmetric cyclization strategies.
Language: Английский
Citations
0Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
Reductive hydroamination of stable and readily available nitroarenes with unsaturated hydrocarbons represents practical access to amines. Herein, we report a simple Cu-catalyzed amine synthesis via the reductive inactive diarylacetylenes. A series diarylacetylenes are successfully transformed into secondary amines under mild conditions good functional group tolerance.
Language: Английский
Citations
0Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
A rhodium(III)-catalyzed dual-ring formation via cascade C-H activation/[4 + 2] annulation of 3,5-diaryoxadiazoles with alkynes was developed. This strategy has been demonstrated a variety 3,5-diaryloxadiazoles and alkynes, it successfully scaled up to gram-scale synthesis, highlighting its potential significance in the direct construction C-N atropisomers. Furthermore, cleavage N-O bond is essential for bicyclic structure absence an external oxidant. Mechanistic studies revealed that at 3-phenyl group oxadiazole likely rate-determining step this reaction.
Language: Английский
Citations
0Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1Organic Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
The synthesis of (iso)quinoline-indole hybrids by reacting (iso)quinoline N-oxides with o-alkynylanilines in the presence a combination copper(II) catalyst and bidentate 2,2′-bipyridine ligand is described. utility this method was demonstrated through site-selective functionalization synthesized products. A plausible reaction pathway for amination followed annulative indole formation elucidated series mechanistic investigations.
Language: Английский
Citations
1ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(46)
Published: Dec. 1, 2024
Abstract Odontothrips loti (Haliday) is a thrip pest of leguminous plants. The aggregation pheromone this and its stereoisomers have been synthesized. central strategy involved enantioselective cross‐coupling racemic benzyl 2‐bromopropanoate with alkenyl Grignard, Evans’ chiral auxiliaries Yamaguchi esterification 2‐methylbutanoic acid lavandulol.
Language: Английский
Citations
0Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113799 - 113799
Published: Dec. 1, 2024
Language: Английский
Citations
0Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140699 - 140699
Published: Nov. 9, 2024
Language: Английский
Citations
0