Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Language: Английский

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Factors that Affect Quantification in Surface-Enhanced Raman Scattering

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Surface-enhanced Raman scattering (SERS) is an analytical technique capable of detecting trace amounts specific species. The uniqueness vibrational signatures a major advantage SERS. This combination sensitivity and specificity has motivated researchers to develop diverse methodologies leveraging However, even 50 years after its first observation, SERS still perceived as unreliable for quantification. perception precluded the application in laboratories that rely on consistent quantification (for regulatory purposes, instance). In this review, we describe some aspects lead intensity variations how those challenges were addressed technique. goal identify sources intensities then demonstrate that, with these pitfalls, can be used when factors such nature substrate, experimental conditions, sample preparation, surface chemistry, data analysis are carefully considered tailored particular application.

Language: Английский

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Multifunctional Fe3O4@ZIF-8@Ag nanocomposites and electro-driven droplet adsorption strategy for SERS detection of acetamiprid

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161149 - 161149

Published: Feb. 1, 2025

Language: Английский

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Advancing liposome and extracellular vesicle characterization through deep learning-enhanced optical trapping and nanoparticle tracking

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113057 - 113057

Published: Feb. 1, 2025

Language: Английский

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A New Perspective on Antimicrobial Therapeutic Drug Monitoring: Surface-enhanced Raman Spectroscopy

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128017 - 128017

Published: March 1, 2025

Language: Английский

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Rapid Fluorochromic Sensing of Tertiary Amines and Opioids via Dual-Emissive Ground and Excited Charge-Transfer States

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

The recognition and differentiation of organic amines are crucial for applications in drug analysis, food spoilage, biomedical assays, clinical diagnostics. Existing luminescence-based methods predominantly rely on fluorescence quenching, limiting the scope sensitive selective detection. Here, we present a fluorochromic approach rapidly distinguishing different based their unique excited-state ground-state interactions with naphthalimide derivative under ultraviolet light. Our findings reveal that photoluminescence quantum yield emission color significantly influenced by substituent group molecular flexibility amine. Specifically, primary amines, together other common lone-pair donors, such as alcohol, ether, thiol, thioether, phosphine, did not exhibit changes, while secondary exhibited only weak emission. For tertiary however, bright green activation was produced molecules containing at least one methyl group; red-shifted yellow observed ones bulkier side groups than methyl; conformationally locked bicycloamines, no observed. In addition, this process depends amine but also shows distinctly ground- dynamics time-resolved spectroscopy. Based these differences, qualitative method is developed visual natural synthetic opioids, including heroin, fentanyl, metonitazene, which more facile rapid compared to current Marquis reagent kit, could facilitate onsite testing, real-time monitoring, streamlined workflows both laboratory field settings.

Language: Английский

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Nano-engineered fiber-based sensing frontiers: Revolutionizing on-site pesticide detection for global food-environment nexus challenges

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216710 - 216710

Published: April 18, 2025

Language: Английский

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