Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Language: Английский
Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12155 - 12155
Published: Nov. 12, 2024
The
interplay
between
functional
food
nutrients
and
neurosteroids
has
garnered
significant
attention
for
its
potential
to
enhance
stress
resilience
in
health
and/or
disease.
Several
bioactive
nutrients,
including
medicinal
herbs,
flavonoids,
bioavailable
polyphenol-combined
nanoparticles,
as
well
probiotics,
vitamin
D
omega-3
fatty
acids,
have
been
shown
improve
blood-brain
barrier
(BBB)
dysfunction,
endogenous
neurosteroid
homeostasis
brain
function.
These
can
inhibit
oxidative
neuroinflammation,
which
are
linked
the
pathogenesis
of
various
neurological
disorders.
Interestingly,
flavonoids
exhibit
dose-dependent
effects,
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
pathway
at
physiological/low
dose
(neurohormesis).
This
leads
upregulation
antioxidant
phase
II
genes
proteins
such
heme
oxygenase-1
(HO-1)
sirtuin-1
(Sirt1),
activated
by
curcumin
resveratrol,
respectively.
adaptive
neuronal
response
mechanisms
help
protect
against
reactive
oxygen
species
(ROS)
neurotoxicity.
Impaired
Nrf2
hormone
signaling
exacerbate
selective
vulnerability
neuroinflammatory
conditions,
contributing
onset
progression
neurodegenerative
psychiatric
disorders,
Alzheimer's
disease,
anxiety
depression
other
due
neurons
stress.
review
focuses
on
targeting
redox
regulate
BBB
damage
associated
with
altered
GABAergic
neurotransmission.
By
exploring
underlying
molecular
using
innovative
technologies,
we
aim
develop
promising
neuroprotective
strategies
personalized
nutritional
neuroregenerative
therapies
prevent
or
attenuate
ultimately
promoting
health.
Language: Английский
Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 915 - 915
Published: Jan. 22, 2025
Polyphenols
are
micronutrients
found
in
fruits,
vegetables,
tea,
coffee,
cocoa,
medicinal
herbs,
fish,
crustaceans,
and
algae.
They
can
also
be
synthesized
using
recombinant
microorganisms.
Interest
plant-derived
natural
compounds
has
grown
due
to
their
potential
therapeutic
effects
with
minimal
side
effects.
This
is
particularly
important
as
the
aging
population
faces
increasing
rates
of
chronic
diseases
such
cancer,
diabetes,
arthritis,
cardiovascular,
neurological
disorders.
Studies
have
highlighted
polyphenols’
capacity
reduce
risk
factors
linked
onset
illnesses.
narrative
review
discusses
polyphenol
families
metabolism,
cardioprotective
polyphenols
evidenced
from
vitro
studies,
well
vivo
on
different
animal
models
cardiac
disease.
study
explores
molecular
mechanisms
underlying
these
benefits.
Current
research
suggests
that
may
protect
against
ischemia,
hypertension,
hypertrophy,
heart
failure,
myocardial
injury
through
complex
mechanisms,
including
epigenetic
genomic
modulation.
However,
further
studies
under
nutritionally
physiologically
relevant
conditions,
untargeted
multigenomic
approaches,
needed
more
comprehensively
elucidate
firmly
prove
polyphenols.
Language: Английский
Metabolic Profiling of a Mediterranean-Inspired (Poly)phenol-Rich Mixture in the Brain: Perfusion Effect and In Vitro Blood–Brain Barrier Transport Validation
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
A
Mediterranean
diet
rich
in
(poly)phenols
has
been
linked
to
neuroprotection,
but
its
effects
likely
depend
on
the
ability
of
phenolic
metabolites
cross
blood-brain
barrier
(BBB).
This
study
evaluated
kinetics
plasma
and
brain
distribution
Sprague-Dawley
rats
following
oral
administration
a
polyphenol-rich
extract
mixture
from
foods
(pomegranate,
lemon,
orange,
grape,
olive).
UPLC-ESI-QTOF
analyses
revealed
39
phenolic-derived
plasma,
which
20
were
nonperfused
(NPB)
19
perfused
brains
(PB),
including
hydroxytyrosol
tyrosol
sulfates,
ellagic
acid,
dihydrocaffeic
derived
metabolites.
Kinetic
data
showed
substantially
higher
metabolite
concentrations
than
brain,
with
slightly
levels
NPB.
The
BBB
transport
efficiency
was
validated
vitro
using
human
microvascular
endothelial
cells
(HBMECs),
showing
improved
when
tested
as
mixtures.
These
findings
confirm
that
circulating
can
reach
tissues,
contributing
preventing
neurodegenerative
diseases.
Language: Английский