Exploring nanodiamonds: leveraging their dual capacities for anticancer photothermal therapy and temperature sensing
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(32), P. 14994 - 15008
Published: Jan. 1, 2024
Cancer
has
become
a
primary
global
health
concern,
which
prompted
increased
attention
towards
targeted
therapeutic
approaches
like
photothermal
therapy
(PTT).
The
unique
optical
and
magnetic
properties
of
nanodiamonds
(NDs)
have
made
them
versatile
nanomaterials
with
promising
applications
in
biomedicine.
This
comprehensive
review
focuses
on
the
potential
NDs
as
multifaceted
platform
for
anticancer
therapy,
mainly
focusing
their
dual
functionality
PTT
temperature
sensing.
highlighted
NDs'
ability
to
enhance
through
hybridization
or
modification,
underscoring
adaptability
delivering
small
molecule
reagents
effectively.
Furthermore,
NDs,
particularly
fluorescent
(FNDs)
negatively
charged
nitrogen-vacancy
centers,
enable
precise
monitoring,
enhancing
efficacy
treatment.
Integrating
FNDs
into
holds
promise
advancing
by
providing
valuable
insights
localized
variations
cell
death
mechanisms.
highlights
new
cancer
treatment
strategies,
showcasing
revolutionize
therapeutics
improve
patient
outcomes.
Language: Английский
Graphene Oxide Nanoparticles for Photothermal Treatment of Hepatocellular Carcinoma Using Low-Intensity Femtosecond Laser Irradiation
Molecules,
Journal Year:
2024,
Volume and Issue:
29(23), P. 5650 - 5650
Published: Nov. 28, 2024
Graphene
oxide-mediated
photothermal
therapy
using
femtosecond
lasers
has
recently
shown
promise
in
treating
hepatocellular
carcinoma.
However,
significant
work
remains
to
optimize
irradiation
parameters
for
specific
nanoparticle
types
and
cancer
cells
improve
nanomaterial-mediated
anticancer
therapy.
This
study
investigated
the
potential
of
nGO
nGO-PEG
nanoparticles
(NPs)
combined
with
laser
at
515
nm
1030
wavelengths,
varying
power
(0.1
0.2
W/cm2)
duration
(5
10
min),
Conversion
efficiency
NPs,
morphology
viability
HepG2
normal
MDCK
after
treatments
were
evaluated
an
electronic
thermometer,
phase-contrast
microscopy,
WST-1
assay.
The
results
revealed
that
NPs
exhibited
better
than
nGO,
inducing
a
temperature
increase
up
19.1
°C
compared
4.7
light.
Laser
exposure
significantly
reduced
cell
viability,
most
intense
conditions
(10
min
causing
decrease
58.2%
43.51%
nGO-PEG.
Normal
showed
minimal
impact
or
slight
increase,
especially
Combined
treatment
induced
morphological
changes
cells,
including
detachment
apoptotic-like
characteristics,
particularly
irradiation.
changes,
some
recovery
observed
under
lower
energy
conditions.
These
findings
suggest
low-energy
engineered
nanomaterials
could
provide
minimally
invasive
approach
side
effects.
Language: Английский