Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33

Published: Dec. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Language: Английский

Electrospun nanofibers of curcumin/HP-beta-CD/pullulan complex with enhanced solubility and controlled release in food and drug delivery applications DOI Creative Commons
Aysu Tolun, Md Sharifuzzaman, Zeynep Altıntaş

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140064 - 140064

Published: Jan. 1, 2025

Curcumin, a hydrophobic drug derived from the rhizome of Curcuma longa, exhibits significant bioactive properties, including antioxidant and antimicrobial potential. However, its poor water solubility rapid degradation limit practical applications. This study presents novel design electrospun nanofibers using Curcumin/hydroxypropyl-β-cyclodextrin inclusion complex (HP-β-CD-IC) combined with pullulan to enhance thermal stability controlled release. In uniaxial nanofibers, curcumin/HP-β-CD-IC is uniformly distributed, whereas in coaxial serves as core material, wall material. X-ray diffraction Fourier-transform infrared spectroscopy confirmed successful formation, fibers showing no crystalline peaks curcumin. Differential scanning calorimetry indicated enhanced stability, melting points shifting 279.19 °C 291.63 for fibers, respectively. Scanning electron microscopy transmission verified core-shell structure uniform morphology. vitro release studies revealed that achieved higher cumulative (93 ± 1.41 %) compared (80 2.82 over 350 min. Antibacterial tests demonstrated improved activity against S. aureus E. coli. Addressing critical need stable bioavailable delivery compounds, this innovative nanofiber holds great promise revolutionizing applications food technology delivery.

Language: Английский

Citations

1
Antimalarial Evaluation of Magnesium Nanoparticlres of Bioactive Compounds Derived From Crinum Jagus Rhizome DOI Creative Commons

Kabir Salsabilu

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Magnesium Nanoparticles (MgNPs), are biocompatible and have shown promise in various biomedical applications, including antimicrobial antimalarial treatments. Synthesis of magnesium nanoparticles from crude extract isolated compound crinum jagus rhizome their activity were reported. mediated by characterized UV-visible spectroscopy, SEM TEM analyses. The absorption results the synthesized showed that varies slightly across wavelength range 343 nm to 353 nm, with a peak value 1.52934 at 345 nm. data for (lupeol) shows significant values relatively high, where absorbance is 0.88005. MgNPs exhibited best (IC50 = 0.1310), significantly outperforming both lupeol-based 0.9103) chloroquine 0.2762). enhanced extract-based may be attributed synergistic effects multiple bioactive compounds present extract. observed this study highlights potential combining traditional plant-based medicine nanotechnology. lower IC50 (0.1310) compared (0.2762) demonstrate promising future approach overcoming drug resistance improving efficacy

Language: Английский

Citations

0
Eco‐Friendly and Smart Electrospun Food Packaging Films Based on Polyvinyl Alcohol and Sumac Extract: Physicochemical, Mechanical, Antibacterial, and Antioxidant Properties DOI Creative Commons

Aylar Shiri,

Ehsan Sadeghi, Khadije Abdolmaleki

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT With the increasing concern over environmental pollution caused by synthetic packaging, there is a growing demand for sustainable, biodegradable, and functional materials in food industry. In this study, antioxidant, antimicrobial, physicochemical, mechanical properties of electrospun edible films based on sumac extract polyvinyl alcohol were investigated. The demonstrated clear colorimetric response to pH changes, shifting from red acidic yellow alkaline conditions, making them suitable packaging freshness monitoring. film containing 30% (P‐SE 30%) exhibited strong antimicrobial activity against Escherichia coli (17.01 mm) Staphylococcus aureus (18.02 mm), along with acceptable antioxidant (46.32%). 10% showed best strength (0.034 MPa). Moreover, moisture content (4.3%) water vapor permeability (9.49 g mm/m 2 Pa) significantly reduced. Also, physicochemical (SEM, FT‐IR, X‐ray, thickness, Opacity, mechanical) improved compared control sample. general, study demonstrates potential reinforced as smart solution enhancing safety.

Language: Английский

Citations

0
Harnessing nanofibers for targeted delivery of phytoconstituents in age-related macular degeneration DOI Creative Commons

Ulia Andrades,

Sahil Gaikar,

Khushali Nathani

et al.

Drug Delivery, Journal Year: 2025, Volume and Issue: 32(1)

Published: April 7, 2025

Age-related macular degeneration is a degenerative eye condition that affects the macula and results in central vision loss. Phytoconstituents show great promise treatment of AMD. AMD therapy can benefit from advantages phytoconstituents loaded nanofibers. There are opportunities to improve effectiveness age-related (AMD) through use nanofiber-based delivery methods. These novel platforms encapsulate distribute plant-derived bioactives by making special qualities include their high surface area-to-volume ratio, variable porosity, biocompatibility. Exploring methods provide choice for enhancing patient adherence, safety, efficacy managing this condition. This article explores potential revolutionize treatment, providing an innovative effective approach treat

Language: Английский

Citations

0
Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33

Published: Dec. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Language: Английский

Citations

0