Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 248, P. 114471 - 114471
Published: Dec. 22, 2024
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216441 - 216441
Published: Feb. 4, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Over the past two decades, nanotechnology has made significant progress toward development and applications of micromotors (MMs) nanomotors (NMs). Characterized by their capability to self-propel swim in fluids, they have emerged as promising tools various fields, particularly biomedicine. This Review presents an overview current state MMs NMs, motion viscous media complex environments, interaction with biological barriers, potential therapeutical applications. We identify choice appropriate administration routes reach target location a key aspect success NMs biomedical Looking ahead, we envision playing role treating diverse medical disorders, recent proof-of-concept vivo studies demonstrate distinct capabilities versatility. However, addressing regulatory, scalability, biocompatibility, safety concerns remains imperative for successful translation into clinical trials industrial-scale production. work provides guideline researchers, guiding them through landscape, challenges, prospects using biomedicine, thereby encouraging responsible positioning future nanomedicine. Furthermore, outline critical areas further research, including on safety, methods overcome physical obstacles.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
Micro/Nanorobots(MNRs)integrated with phototherapy represent an emerging approach to cancer treatment and hold significant potential for addressing bacterial infections, neurological disorders, cardiovascular diseases, related conditions. By leveraging micro/nanoscale motor systems in conjunction phototherapy, these robots enable real-time guidance monitoring of therapeutic processes, improving drug delivery precision efficiency. This integration not only enhances the effectiveness but also minimizes damage surrounding healthy tissues. Nevertheless, clinical translation MNRs-assisted still faces numerous challenges. In this review, recent key developments field are comprehensively summarized, critical roles applications highlighted, insights into future directions pathway toward large-scale implementation provided.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: May 16, 2025
The limited lifespan of enzyme-powered micro/nanomotors (MNMs) hinders their biomedical applications due to the easy deactivation in tumor microenvironments. In this study, by taking advantage hydrogen bond-rich metal-organic frameworks (MOFs), we design anti-biopassivated urease-powered MOF motors (Ur-MOFtors) with sustained motility for bladder cancer therapy. Such reticular Ur-MOFtors exhibited an exceptionally long locomotion exceeding 90 min highly concentrated urea, which was 18-fold enhancement compared urease-adsorbed MOFs, resulting excellent anti-biopassivation MOFtors. underlying molecular mechanism persistent motion involves bonding interaction between skeleton and catalytic product, as identified situ infrared spectroscopy density functional theory. Based on preserved enzymatic activity comparable native urease, self-propulsion pathway is driven ionic self-diffusiophoresis positive chemotactic toward urea. Benefiting from physiological a rapid therapy achieved few instillation sessions short treatment cycles during intravesical administration. This framework presents promising approach overcoming advanced therapeutic robotics.
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 248, P. 114471 - 114471
Published: Dec. 22, 2024
Language: Английский
Citations
2