Catalytic Construction of C(sp3)‐Ge Bonds: Recent Advances and Future Perspectives DOI
Jia‐Lin Tu, Binbin Huang

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(22), P. 4618 - 4633

Published: Oct. 16, 2024

Abstract Germanium (Ge), a congener of carbon, possesses unique properties that hold extensive potential for applications across multiple domains. Recent years have seen significant progress in the development carbon‐germanium bond formation strategies, particularly those more challenging C( sp 3 )−Ge bonds. This review systematically summarizes recent advances forming methodologies, with particular emphasis on (1) versatility transition‐metals, including iron, nickel, copper, rhodium and palladium, as catalysts broadening reaction scope controlling selectivity; (2) powerfulness organic photocatalysis achieving mild selective formation, (3) sustainability catalytic electrosynthesis facilitating chemical oxidant‐/reductant‐ free conversions. Additionally, examples (4) non‐catalytic strategies are also discussed. The representative scopes, well mechanistic proposals, these protocols highlighted. Through an overview current state research, this aims to offer insights into construction bonds, provide perspectives future research directions address challenges.

Language: Английский

Visible-light induced direct C(sp3)–H functionalization: recent advances and future prospects DOI
Jia‐Lin Tu, Yining Zhu, Pengcheng Li

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5278 - 5305

Published: Jan. 1, 2024

This review summarizes the latest methodological advances in photocatalytic C(sp 3 )–H functionalization, with a particular emphasis on formation of C–P, C–B, C–S bonds, etc ., and some prominent efforts asymmetric C–H functionalization.

Language: Английский

Citations

17
Direct C(sp3)-H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents DOI
Jia‐Lin Tu, Binbin Huang

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Recent years have witnessed the emergence of direct intermolecular C(sp

Language: Английский

Citations

9
Light‐Induced Direct Decarboxylative Functionalization of Aromatic Carboxylic Acids DOI Open Access
Jia‐Lin Tu, Zhengjia Shen, Binbin Huang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(21), P. 4263 - 4273

Published: Aug. 28, 2024

Abstract Aryl radicals are important intermediates in organic synthesis. The generation of these reactive species via direct decarboxylation inexpensive and readily available aromatic carboxylic acids is an attractive goal. However, such a process intrinsically exhibits high energy barriers to overcome, which consequence usually require precious metal catalysis, stoichiometric oxidants harsh conditions, suffering from limitations as poor functional group tolerance low atom economy. In recent years, photochemical reactions have provided new approaches address this challenge. Three major strategies been introduced emerging field: 1) one‐pot in‐situ activation benzoic generate benzoyl hypobromites or hypoiodites; 2) the use specialized photocatalysts like biphenyl/1,4‐dicyanobenzene promote through photo‐induced electron transfer charge processes; 3) LMCT (Ligand‐to‐Metal Charge Transfer) strategy where copper iron salts coordinate carboxylate anion upon visible light excitation. On basis three strategies, review will systematically summarize development visible‐light‐induced decarboxylative functionalization acids, focusing on reaction mechanism substrate scope, discuss their prospects

Language: Английский

Citations

4
Synthesis, Characterization, and Light Sensitivity in Titanium Piano Stool Alkyl and Sulfur Complexes, [(C5Me5)TiMe2R]n− (R = Me, SCPh3, S; n = 0, 1) DOI Creative Commons

Bayler G. Barnes,

Alejandro J. Metta‐Magaña, Eric W. Reinheimer

et al.

Organometallics, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Language: Английский

Citations

0
Recent Progress in Metal-Catalyzed C(sp³)-P Bond Formation DOI
Jia‐Lin Tu, Zhengjia Shen, Binbin Huang

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 168, P. 134352 - 134352

Published: Nov. 1, 2024

Language: Английский

Citations

2
Photo- and Electro-chemical Strategies for Indazole Synthesis DOI Creative Commons
Binbin Huang

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: unknown, P. 100116 - 100116

Published: Dec. 1, 2024

The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential medicinal chemistry and drug discovery, which therefore has attracted sustained attention from synthetic community. Over recent decades, significant progress been achieved both organic photocatalysis electrosynthesis, offering novel approaches for efficient sustainable synthesis various functionalized indazoles. This mini-review highlights emerging methodological advancements photo-/electro-chemical two common forms indazole, namely 1H- 2H-indazoles, are classified by specific intramolecular bond formation patterns: (1) C-C formation, (2) C-N (3) N-N formation. reaction conditions, representative scopes, mechanistic understandings these protocols emphasized, to elucidate advantages limitations current strategies, with an aim inspire future innovations that may address challenges modern synthesis.Graphical abstractTo create your abstract, type over instructions template box below. Fonts or abstract dimensions should not be changed altered.

Language: Английский

Citations

2
Catalytic Construction of C(sp3)‐Ge Bonds: Recent Advances and Future Perspectives DOI
Jia‐Lin Tu, Binbin Huang

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(22), P. 4618 - 4633

Published: Oct. 16, 2024

Abstract Germanium (Ge), a congener of carbon, possesses unique properties that hold extensive potential for applications across multiple domains. Recent years have seen significant progress in the development carbon‐germanium bond formation strategies, particularly those more challenging C( sp 3 )−Ge bonds. This review systematically summarizes recent advances forming methodologies, with particular emphasis on (1) versatility transition‐metals, including iron, nickel, copper, rhodium and palladium, as catalysts broadening reaction scope controlling selectivity; (2) powerfulness organic photocatalysis achieving mild selective formation, (3) sustainability catalytic electrosynthesis facilitating chemical oxidant‐/reductant‐ free conversions. Additionally, examples (4) non‐catalytic strategies are also discussed. The representative scopes, well mechanistic proposals, these protocols highlighted. Through an overview current state research, this aims to offer insights into construction bonds, provide perspectives future research directions address challenges.

Language: Английский

Citations

1