Base‐free Synthesis of S‐Alkyl Isothioureas Through Ring‐opening Reaction of Sulfonium Salts with Isothiocyanates and Amines DOI
Cunwei Qian, Wei Xiang,

Meng-Qing Gu

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 31(8)

Published: Dec. 6, 2024

A convenient and base-free three-component reaction has been developed for the synthesis of S-alkyl substituted isothioureas from cyclic sulfonium salts, isothiocyanates, amines. This protocol provides an alternative avenue to access a series in moderate good yields through ring-opening aryl, alkenyl alkynyl salts. The present strategy features operational simplicity, functional group tolerance, gram-scale high efficiency.

Language: Английский

Visible-Light-Induced Phosphorothioation of Alkenyl Sulfonium Salts with S8 and H-Phosphonates DOI
Lihua Yang,

Ni-Dan Meng,

Li Tang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

An efficient and practical method for synthesizing vinyl phosphorothioates has been demonstrated through a visible-light-induced three-component reaction of alkenyl sulfonium salts, S8, H-phosphonates. This facilitates the synthesis diverse range with wide substrate scope functional group tolerance. Preliminary mechanistic studies suggest that involves phosphorothioate radical-triggered process.

Language: Английский

Citations

0
Manual Grinding and Sunlight Synergistically Promoted Sulfonylation of Alkenyl Sulfonium Salts with Sulfinic Acids DOI
Lihua Yang, Lin Chen, Weijun Yao

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

An environmentally friendly and practical method for the synthesis of various vinyl sulfones was developed through direct sulfonylation alkenyl sulfonium salts with sulfinic acids. The reaction effectively triggered by combined actions milling, sunlight, photocatalysts under solvent-free conditions, offering advantages such as a short time (5-10 min), room temperature, straightforward workup procedure. Preliminary mechanistic studies suggested that sulfonyl radical may be involved in this mechanophotocatalytic transformation process.

Language: Английский

Citations

0
New Frontiers in Phosphorothioate Formation: Harnessing Inorganic Phosphorus Sources DOI
Jiawei He,

Xuesi Zhou,

Zixuan Wan

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(99), P. 14691 - 14702

Published: Jan. 1, 2024

This review highlights the latest advancements in synthesis of phosphorothioates and their derivatives from inorganic phosphorus sources, focusing on applicability, mechanisms, current limitations, potential future directions.

Language: Английский

Citations

0
Base‐free Synthesis of S‐Alkyl Isothioureas Through Ring‐opening Reaction of Sulfonium Salts with Isothiocyanates and Amines DOI
Cunwei Qian, Wei Xiang,

Meng-Qing Gu

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 31(8)

Published: Dec. 6, 2024

A convenient and base-free three-component reaction has been developed for the synthesis of S-alkyl substituted isothioureas from cyclic sulfonium salts, isothiocyanates, amines. This protocol provides an alternative avenue to access a series in moderate good yields through ring-opening aryl, alkenyl alkynyl salts. The present strategy features operational simplicity, functional group tolerance, gram-scale high efficiency.

Language: Английский

Citations

0