New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

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"Harnessing Green Synthesized Zinc Oxide Nanoparticles for Dual Action in Wound Management: Antibiotic Delivery and Healing Promotion"

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107314 - 107314

Published: Jan. 1, 2025

Language: Английский

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Advancing Nanotechnology: Targeting Biofilm-Forming Bacteria with Antimicrobial Peptides

BME Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Nanotechnology offers innovative solutions for addressing the challenges posed by biofilm-forming bacteria, which are highly resistant to conventional antimicrobial therapies. This review explores integration of pharmaceutical nanotechnology with peptides (AMPs) enhance treatment biofilm-related infections. The use various nanoparticle systems-including inorganic/metallic, polymeric, lipid-based, and dendrimer nanostructures-provides promising avenues improving drug delivery, targeting, biofilm disruption. These nanocarriers facilitate penetration biofilms, down-regulate biofilm-associated genes, such as ALS1, ALS3, EFG1, HWP1, inhibit bacterial defense mechanisms through membrane disruption, reactive oxygen species generation, intracellular targeting. Furthermore, formulations NZ2114-NPs demonstrate enhanced efficacy reducing counts several orders magnitude. highlights potential combining AMPs create novel, targeted therapeutic approaches combatting infections overcoming limitations traditional treatments.

Language: Английский

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Engineering Multiresponsive Alginate/PNIPAM/Carbon Nanotube Nanocomposite Hydrogels as On‐Demand Drug Delivery Platforms

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Abstract Second near‐infrared (NIR‐II) responsive hydrogels have shown significant potential in biomedical applications due to their excellent remote actuation property and the high tissue penetrations of NIR‐II light. Nevertheless, with a single light response may not meet diverse requirements complex conditions clinical applications. Here, novel multi‐responsive nanocomposite hydrogel enhanced suitability for controlled drug release is developed. This constructed by combining alginate dialdehyde (ADA), polyethyleneimine (PEI), poly(N‐isopropylacrylamide) (PNIPAM), phenylboronic acid‐modified (PBA‐PEI) functionalized multi‐walled carbon nanotubes (PP‐CNT) through formation dynamic covalent bonds (i.e., imine boronate ester bonds), forming ADA/PEI/PNIPAM/PP‐CNT (APN/PP‐CNT) hydrogel. PNIPAM incorporated into network facilitate triggered its aggregation when subjected temperatures produced irradiation. The CNT provide APN/PP‐CNT responsiveness multiple stimuli, including pH, hydrogen peroxide, temperature, performs effective both vitro vivo release, highlighting as promising delivery platform.

Language: Английский

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Synthesis, Cytotoxic and Genotoxic Evaluation of Drug-Loaded Silver Nanoparticles with Mebeverine and Its Analog

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 397 - 397

Published: March 12, 2025

Background: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder with complex pathogenesis that necessitates innovative therapeutic approaches for effective management. Among the commonly used treatments, mebeverine (MBH), an antispasmodic, widely prescribed to alleviate IBS symptoms. However, challenges in delivering drug precisely colonic region often hinder its effectiveness. To address this limitation, silver nanoparticles (AgNPs) have emerged as promising delivery systems, offering unique physicochemical properties can enhance precision and efficacy of treatments. Objectives: This study aimed synthesize AgNPs vehicles MBH previously reported analog. The research focused on evaluating cytotoxic genotoxic effects forecasting their possibly harmful future sustainable development. Methods: were synthesized using rapid method functionalized characterized different techniques. Cytotoxicity genotoxicity evaluated vitro. Additionally, silico docking analyses performed explore safety profile further. Results: In vitro assays revealed concentration-dependent lack MBH-loaded AgNPs. A molecular simulation was confirm effect. Conclusions: underscores potential advanced systems safe significant implications IBS. Future vivo preclinical investigations are essential validate range exposure doses evaluation standards assessing AgNPs’ targeted personalized medicine.

Language: Английский

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Comprehensive review of metal complexes and nanocomposites: Synthesis, characterization, and multifaceted biological applications

Engineering Science & Technology Journal, Journal Year: 2024, Volume and Issue: 5(6), P. 1935 - 1951

Published: June 13, 2024

This review paper provides an extensive analysis of the synthesis, characterization, and multifaceted biological applications metal complexes nanocomposites derived from a diverse array biopolymeric ligands. These ligands, including chitosan, 2-hydroxybenzaldehyde, 4-aminopyridine imine, among others, have shown remarkable potential due to their biocompatibility, biodegradability, functional versatility. The delves into various synthetic strategies, conventional green synthesis approaches, highlights advanced characterization techniques such as spectroscopy, microscopy, thermal analysis, X-ray diffraction. Emphasizing broad spectrum activities exhibited by these compounds, covers antimicrobial, anticancer, antioxidant, enzyme inhibition, drug delivery applications. By synthesizing current research identifying key challenges future directions, this aims provide valuable insights for researchers in medicinal chemistry, materials science, biotechnology, related fields. Keywords: Metal Complexes, Nanocomposites, Synthesis, Characterization, Biological Application.

Language: Английский

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Cellulose-based antimicrobial hydrogels

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 189 - 207

Published: Jan. 1, 2025

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Advances in sensing technologies using functional carbon nanotube-hydrogel nanocomposites

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114139 - 114139

Published: Feb. 1, 2025

Language: Английский

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Advancements in Prehospital, En-Route, and Damage Control Casualty Care and Areas of Future Research for Large-Scale Combat Operations

Current Trauma Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 20, 2025

Abstract Purpose of Review The purpose this review is to describe the advancements in combat casualty care from prehospital environment, through en route care, and into damage control resuscitative surgical during recent military conflict. We also explore potential areas future research needed enhance survivability on battlefield large-scale operations (LSCO). Recent Findings In space, use tourniquets has become standard practice for controlling severe hemorrhage, while techniques like Resuscitative Endovascular Balloon Occlusion Aorta (REBOA) continue be researched managing hemorrhagic shock. Implementing whole blood transfusions freeze-dried plasma enables hemostatic resuscitation. Pain management strategies are evolving, with ketamine, Penthrox, fentanyl. During concept “golden hour” emphasizes urgency delivering timely medical intervention, critical paramedics play an essential role setting. En resuscitation teams enable rapid, lifesaving interventions patient transport. Within surgery, focus shifted towards products counteract coagulopathy prevent further bleeding. Damage laparotomy remains a intervention abdominal injuries, vascular shunting being utilized extensively stabilize patients limb-threatening injuries. Likewise, acellular vessel conduits novel, promising innovation, offering bioengineered solution repair. For LSCO, novel must delve anti-shock drugs aimed at enhancing hemodynamic stability, Extracorporeal Membrane Oxygenation trauma, development antimicrobials post-traumatic infections. Directed energy technologies, telemedicine, decision-assist tools, autonomous systems investigated, transform trauma by improving response times treatment efficacy remote or resource-limited environments. Summary advancements, such as hemorrhage methods REBOA, alongside innovations plasma, exemplify care. golden hour policy, resuscitation, improvement capabilities highlight importance saving lives. Novel areas, including drugs, ECMO, antimicrobials, directed systems, could operations.

Language: Английский

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