Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel DOI Creative Commons
Jing Yang,

Donghui Jia,

Jialu Qiao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11499 - 11516

Published: Nov. 1, 2024

The photo-activated thermo/gas antimicrobial nanocomposite hydrogel, Gel/PDA@BNN6, is composed of the nitric oxide (NO) carrier N, N'-di-sec-butyl-N, N'-dinitroso-p-phenylenediamine (BNN6), photothermal (PTT) material polydopamine nanoparticles (PDA NPs), and methacrylate gelatin (GelMA). This hydrogel can release NO gas in a stable controlled manner, generating localized effect when exposed to near-infrared laser light. dual action promotes healing full-thickness skin wounds that are infected.

Language: Английский

Stability and Properties of Ultraviolet Filter Avobenzone under Its Diketo/Enol Tautomerization Induced by Molecular Encapsulation with β-Cyclodextrin DOI Creative Commons
Chihiro Kuroda, Tomohiro Tsuchida,

Chihiro Tsunoda

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Inclusion complexation of the sunscreen ingredient avobenzone (AVB) with β-cyclodextrin (β-CD) was investigated to improve its aqueous solubility and photostability; another ultraviolet (UV) filter, oxybenzone (OXB), phytochemical antioxidant curcumin (CUR) served as a comparison. In this study, 1-octanol/water partition coefficients, acid dissociation constants, phase-solubility diagrams β-CD, ultraviolet–visible (UV–vis) spectral changes induced by UVA1 (365 nm) irradiation were evaluated. β-CD at concentrations 50–100 times that AVB most effectively protected photostability AVB. Additionally, an UVA1-insensitive species diketo tautomer, which has UVC-absorbing band potential cause photodegradation, stored in inclusion complex. Acetonitrile–water mixtures various volume ratios screened mimic internal cavity for tautomeric using nuclear magnetic resonance (NMR) integrals components. The results indicated provides hydrophobic environment similar 40–50% acetonitrile solution enhances However, excess hyperchromic effect on tautomer. Aggregation AVB/β-CD complexes ≥2 mM UVC absorption. To avoid molar ratio is recommended optimal composition. This study newly exhibited mitigates reactivity toward inducing tautomer form within cavity.

Language: Английский

Citations

1
Thiolated and Carboxymethylated Jackfruit Seed Starch Nanocrystals as Polymeric Drug Carriers for Curcumin Delivery to Cancer Cells DOI Open Access
Olalekan Adeyinka Balogun‐Agbaje, Michael Ayodele Odeniyi

Starch - Stärke, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

ABSTRACT Jackfruit seeds are rich in starch and can be used as an alternative source of the polymer. Starch nanocrystals act a carrier to improve curcumin's anti‐cancer effect. This study evaluated modified jackfruit carriers for delivering curcumin MCF‐7 breast cancer cell lines. Nanocrystals were prepared by acid hydrolysis carboxymethylation thiolation. The forms characterized scanning electron microscopy, X‐ray diffraction, Fourier transform infrared spectroscopy, drug loading, mucoadhesion, toxicity. Curcumin‐loaded starches vitro release cytotoxicity on cells. had average particle size 6.15 ± 0.80 nm, with altered morphology after modification. starch's crystallinity (27.18%) increased (37.54%) thiolation (41.37%) but decreased (23.29%). highest loading (70.23% 0.23%) was recorded carboxymethylated nanocrystals, then thiolated (63.37% 0.40%), lowest (49.31% 0.13%) native starch. Mucoadhesion improved thiolation, curcumin‐loaded produced IC 50 value (42.5 0.12 µm/mL) lower than plain (86.80 0.10 µm/mL). Modified possess acceptable properties potential candidates effective delivery

Language: Английский

Citations

0
Chitosan/hydroxypropyl methylcellulose acetate succinate nanoparticles as a promising delivery system for curcumin in MDA-MB-231 breast cancer cells DOI

Layla Schlichting,

Giuliana Valentini,

Bruna Mattos Dos Santos

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127600 - 127600

Published: April 1, 2025

Language: Английский

Citations

0
Carbohydrate polymer-based nanoparticles in curcumin delivery for cancer therapy: A review DOI
Kexin Meng,

Xintong Tu,

F.W. Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140441 - 140441

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanoparticles for Photodynamic Therapy of Breast Cancer: A Review of Recent Studies DOI Creative Commons
Dorota Bartusik‐Aebisher, Agnieszka Przygórzewska, Paweł Woźnicki

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1571 - 1571

Published: March 31, 2025

Photodynamic therapy (PDT) is a therapeutic method based on the interaction between light and photosensitizer. Supported by nanoparticles, this represents promising interdisciplinary approach for treatment of many diseases. This article reviews latest 2024 developments in design applications nanoparticles dedicated to stand-alone PDT breast cancer. Strategies improve efficacy enhancing reactive oxygen species (ROS) production, precise delivery photosensitizers their stabilization systemic circulation are discussed, among others. Results from preclinical studies indicate significant improvements efficacy, including inhibition tumor growth, reduction metastasis improvement immune microenvironment. The potential these technologies expand medicine need further clinical trials confirm safety highlighted.

Language: Английский

Citations

0
Nanometer preparation of natural bioactive compounds for treatment of rheumatoid arthritis DOI Creative Commons

Junping Zhu,

Xiang Qin, Qi Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101341 - 101341

Published: May 1, 2025

Language: Английский

Citations

0
Targeted non-invasive Metformin-Curcumin co-loaded nanohyaluosomes halt osteoarthritis progression and improve articular cartilage structure: A preclinical study DOI

Mennatallah E. El-Haddad,

Wessam M. El-Refaie, Ghada O Hammad

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124845 - 124845

Published: Oct. 1, 2024

Language: Английский

Citations

0
Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel DOI Creative Commons
Jing Yang,

Donghui Jia,

Jialu Qiao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11499 - 11516

Published: Nov. 1, 2024

The photo-activated thermo/gas antimicrobial nanocomposite hydrogel, Gel/PDA@BNN6, is composed of the nitric oxide (NO) carrier N, N'-di-sec-butyl-N, N'-dinitroso-p-phenylenediamine (BNN6), photothermal (PTT) material polydopamine nanoparticles (PDA NPs), and methacrylate gelatin (GelMA). This hydrogel can release NO gas in a stable controlled manner, generating localized effect when exposed to near-infrared laser light. dual action promotes healing full-thickness skin wounds that are infected.

Language: Английский

Citations

0