An Investigation into the Preparation, Characterization, and Therapeutic Applications of Novel Gefitinib/Capric Acid Deep Eutectic Systems DOI Creative Commons
Faisal Al‐Akayleh, Bayan Alkhawaja, Mayyas Al‐Remawi

et al.

Journal of Pharmaceutical Innovation, Journal Year: 2024, Volume and Issue: 19(6)

Published: Nov. 28, 2024

In this work, we sought to report and fully characterise novel therapeutic deep eutectic systems (THEDESs) formed between Gefitinib (Gef) capric acid (CA). addition, will study the impact of formulation on solubility efficacy. The THEDES were using a simple preparation method. Gef CA mixed in increasing molar ratios at 40 °C. A phase diagram was used identify an optimal ratio for formation. Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), NMR systems. Lastly, Cytotoxicity assessments EGFR-expressing cell lines conducted evaluate efficacy formulations. According diagram, Gef: found be G2 (80:20), which facilitates formation homogeneous liquid system room temperature, confirmed by DSC. FTIR analysis revealed significant shifts specific peaks, indicating hydrogen bonding CA. More specifically, downfield shift observed protons adjacent tertiary nitrogen morpholine ring. enhanced considerably, 30,000 times higher than aqueous solutions pH 5. according cytotoxicity tests, THEDESs, particularly G3 formulations, have significantly reduced IC50 values compared individual components, demonstrating synergistic effect. work reports THEDESs CA, enhance exhibit cytotoxic effect against lines. These findings suggest that could offer promising facile approach improving poorly soluble drugs.

Language: Английский

Prebiotics Beyond the Gut: Omics Insights, Artificial Intelligence, and Clinical Trials in Organ-Specific Applications DOI
I.S.I. Al-Adham, Ahmed S.A. Ali Agha, Faisal Al‐Akayleh

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

1
Novel therapeutic deep eutectic system for the enhancement of ketoconazole antifungal activity and transdermal permeability DOI

Faisal Al-Akayleh,

Bayan Alkhawaja, Nizar Al-Zoubi

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 413, P. 125975 - 125975

Published: Sept. 12, 2024

Language: Английский

Citations

4
Eutectic-based self-emulsifying drug delivery system for enhanced oral delivery of risperidone DOI
Aaqil Rifai, Bayan Alkhawaja, Faisal Al‐Akayleh

et al.

Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 2, 2025

Implementing therapeutic deep eutectic systems (THDESs) in various drug delivery (DDSs) has expanded enormously. THDESs offer eco-friendly alternatives to conventional organic solvents, featuring adaptable and simple preparation methods with high-yield products. Previously, the solubility of risperidone (RISP) was immensely enhanced by forming a hydrophobic THDES RISP capric acid (CA). To build upon previous findings utilize properties THDES, self-emulsifying system (SEDDS) developed. A stable SEDDS formulation successfully developed using as nonpolar phase, nonionic surfactant, Tween 20, co-surfactant, PEG 400. By employing pseudo-ternary phase diagram, ideal ratio 20 400 determined be 3:1. The demonstrated robust stability thermal tests, dispersity evaluations, dilution exhibiting no instances separation or precipitation. Gratifyingly, vitro dissolution through showed higher release 3-fold after 5 min achieved 90% within 2 hours. More interestingly, plasma profile were compared rats, which revealed an improved bioavailability, indicated attained AUC0–∞ (3907.06 versus 3426.28 h µg/ml) significantly Cmax (68.97 50.35 when RISP.

Language: Английский

Citations

0
Antioxidant Activity and UHPLC-MS/MS Characterization of Polyphenol and Nicotine Content in Nicotiana Glauca Leaf Extracts: A Comparative Study of Conventional and Deep Eutectic Solvent Extraction Methods DOI Creative Commons

Reem Issa,

Faisal Al-Akayleh,

Lilian Alnsour

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2240 - 2240

Published: Aug. 13, 2024

The leaves of Nicotiana glauca (N. glauca; Solanaceae) plant are a known, major human health concern. This study investigated the antioxidant activity and polyphenols composition aerial parts N. collected from its wild habitat in Jordan, using Methanol-Conventional (MC) deep eutectic solvents (DES) extraction methods addition to nicotine content determination UHPLC. Our results showed that MC extract contains fewer total phenols flavonoid than 90% DES extract, (0.1194 ± 0.009 0.311 0.020 mg/mL equivalent gallic acid) (0.01084 0.005 0.928 0.09 rutin), respectively. Moreover, this prepared contain 635.07 ppm nicotine, while 1194.91 nicotine. Extracts exhibited weak activities; highest was 33% inhibition rate (equivalent ascorbic acid), obtained by extract,. performed UHPLC-MS/MS analysis also revealed presence variations detected compounds between two methods. Furthermore, found environmentally friendly produced higher phenol method; highlights superior efficiency environmental benefits sustainable chemistry for extracting valuable phytoconstituents.

Language: Английский

Citations

3
Recent Advances in Ocular Drug Delivery: Insights into Lyotropic Liquid Crystals DOI Creative Commons
Samer Adwan,

Madeiha Qasmieh,

Faisal Al‐Akayleh

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1315 - 1315

Published: Oct. 2, 2024

This review examines the evolution of lyotropic liquid crystals (LLCs) in ocular drug delivery, focusing on their ability to address challenges associated with traditional ophthalmic formulations. study aims underscore enhanced bioavailability, prolonged retention, and controlled release properties LLCs that significantly improve therapeutic outcomes.

Language: Английский

Citations

3
Antioxidant Activity and UHPLC-MS/MS Characterization of Polyphenol and Nicotine Content of <em>Nicotiana glauca</em> Leaf Extracts: A Comparative Study of Conventional and Deep Eutectic Solvent Extraction Methods DOI Open Access

Reem Issa,

Faisal Al‐Akayleh, Lilian Alnsour

et al.

Published: June 19, 2024

The leaves of Nicotiana glauca (Solanaceae) plant, are known for its major cause health concern. This study investigated the antioxidant activity and polyphenols composition aerial parts N.glauca collected from wild habitat in Jordan, using Methanol-Conventional (MC) deep eutectic solvents (DESs) extraction methods addition to nicotine content determination UHPLC. results have shown that MC extract contains fewer total phenols flavonoid than DES at ratio 90% (0.1194 ±0.009 0.311± 0.020 mg/mL equivalent gallic acid) (0.01084±0.005 0.928 ± 0.09 rutin), respectively. Moreover, showed 635.07 ppm compared method, which 1194.91 ppm. Both extracts exhibited weak activities with highest was 33%inhibition ascorbic acid found (90%) ratio. UHPLC-MS/MS analysis revealed presence variations detected compounds between two used. en-vironmentally friendly N. produced higher phenol highlighting green chemistry methods&#039; superior efficiency environmental benefits extracting valuable phytoconstituents.

Language: Английский

Citations

2
An Investigation into the Preparation, Characterization, and Therapeutic Applications of Novel Gefitinib/Capric Acid Deep Eutectic Systems DOI Creative Commons
Faisal Al‐Akayleh, Bayan Alkhawaja, Mayyas Al‐Remawi

et al.

Journal of Pharmaceutical Innovation, Journal Year: 2024, Volume and Issue: 19(6)

Published: Nov. 28, 2024

In this work, we sought to report and fully characterise novel therapeutic deep eutectic systems (THEDESs) formed between Gefitinib (Gef) capric acid (CA). addition, will study the impact of formulation on solubility efficacy. The THEDES were using a simple preparation method. Gef CA mixed in increasing molar ratios at 40 °C. A phase diagram was used identify an optimal ratio for formation. Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), NMR systems. Lastly, Cytotoxicity assessments EGFR-expressing cell lines conducted evaluate efficacy formulations. According diagram, Gef: found be G2 (80:20), which facilitates formation homogeneous liquid system room temperature, confirmed by DSC. FTIR analysis revealed significant shifts specific peaks, indicating hydrogen bonding CA. More specifically, downfield shift observed protons adjacent tertiary nitrogen morpholine ring. enhanced considerably, 30,000 times higher than aqueous solutions pH 5. according cytotoxicity tests, THEDESs, particularly G3 formulations, have significantly reduced IC50 values compared individual components, demonstrating synergistic effect. work reports THEDESs CA, enhance exhibit cytotoxic effect against lines. These findings suggest that could offer promising facile approach improving poorly soluble drugs.

Language: Английский

Citations

1