Cited by Synthesis of N-Aroyl methylsulfonyl-substituted phenylalanine esters via enzyme-catalyzed dynamic kinetic resolution of azlactones

Chiral Aldehyde/Palladium Catalysis Enables Asymmetric Branched-Selective Ring-Opening Functionalization of Methylenecyclopropanes with Amino Acid Esters DOI

Fang Zhu, Hui He, Wen Wei

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Achieving catalytic asymmetric functionalization of methylenecyclopropanes (MCPs) by selective C–C bond cleavage is a notable challenge due to the intricate reaction partners involved. In this work, we report that chiral aldehyde/palladium combined catalysis enables MCPs with NH2-unprotected amino acid esters. This proceeds through regiospecific branched ring-opening mechanism, resulting in optically active α,α-disubstituted α-amino esters bearing nonconjugated terminal alkene units. Mechanism studies indicate pathways are irreversible and ultimate regioselectivity governed palladium catalysis. The products can be utilized construction dihydropyrazoles, α-methyl aspartic derivatives, analogues VPC01091 BMS-986104.

Language: Английский

Citations

Advances in organocatalyzed synthesis of organic compounds DOI

Ayesha Zafar, Muhammad Adnan Iqbal,

Ghazala Iram

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(28), P. 20365 - 20389

Published: Jan. 1, 2024

The recent advancements in utilizing organocatalysts for the synthesis of organic compounds have been described this review by focusing on their simplicity, effectiveness, reproducibility, and high selectivity which lead to excellent product yields. organocatalytic methods various derivatives, such as indoles, pyrazolones, anthrone-functionalized benzylic amines, maleimide, polyester, phthalimides, dihydropyrimidin, heteroaryls,

Language: Английский

Citations

Stereocontrolled synthesis of an α–monosubstituted α–amino acid derivative from a Ugi reaction product DOI

Shuntaro Tsukamoto,

Yuki Suzuki,

Masato Oikawa

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155488 - 155488

Published: Jan. 1, 2025

Language: Английский

Citations

Backbone-Determined Antiarrhythmic Structure–Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product DOI

Madelaine P. Thorpe, Daniel J. Blackwell, Björn C. Knollmann

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(14), P. 12205 - 12220

Published: July 3, 2024

Cyclic oligomeric depsipeptides (COD) are a structural class within naturally occurring compounds with wide range of biological activity. Verticilide is COD (24-membered ring) that was identified by its inhibition insect ryanodine receptor (RyR). We have since found the enantiomer verticilide (

Language: Английский

Citations

Chiral aggregates of rod-coil molecules inside nanopores as efficient nanoreactors for asymmetric synthesis DOI

Huiyu Zhao, Qing Xu,

Gui-Lang Liu

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(36), P. 14692 - 14698

Published: Jan. 1, 2024

Chiral aggregation of rod-coil molecules inside nanopores resulted in efficient asymmetric synthesis as well good durability and recyclability.

Language: Английский

Citations

1-Adamantanamine implementation in surface engineering of biomimetic PVDF-based membranes for enhanced membrane distillation DOI

Samer Al‐Gharabli, Nafisah Al‐Rifai,

Simona Jurevičiūtė

et al.

Desalination, Journal Year: 2024, Volume and Issue: unknown, P. 118331 - 118331

Published: Nov. 1, 2024

Language: Английский

Citations

Synthesis of N-Aroyl methylsulfonyl-substituted phenylalanine esters via enzyme-catalyzed dynamic kinetic resolution of azlactones DOI

Peng Wang,

Chunzhi Ju,

Lingkai Kong

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 171, P. 134413 - 134413

Published: Dec. 11, 2024

Language: Английский

Citations